protein

APOEPROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about APOEPROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Hypotheses

0Analyses

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0Experiments

No summary available yet. View on Wiki →

🔬 Protein Info

Gene Symbol	APOEPROTEIN
Chromosome	19q13.2
Target Class	Ligand
Function	is a 34 kDa secreted glycoprotein that serves as the primary cholesterol transport protein in the brain and plays a central role in lipid metabolism, synaptic repair, and neuroinflammation[@mahley2...
Mechanism of Action	Protein-protein interaction modulator or lipid metabolism enhancer
Druggability	Medium (0.47)
Clinical Stage	Phase II
Molecular Weight	34 kDa
GeneCards	APOEPROTEIN
Human Protein Atlas	APOEPROTEIN
Interactor	Function
LDLR	Cholesterol uptake
LRP1	Aβ clearance, signaling
APOER2/LRP8	Reelin signaling, synaptic plasticity
[Amyloid-β](proteins/amyloid-beta)	Aggregation, clearance
Associated Diseases	AD, AGING, ALS, ALZHEIMER, ALZHEIMER'S DISEASE, AMI
Known Drugs/Compounds	LIPOPROTEINS, Lipid-Targeting Therapeutic Strategies, LECANEMAB, RESVERATROL, CURCUMIN, Gene Therapy
Interactions	LRP1, LDLR, LOX, IL6, SREBF1, PSEN2
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	APOE4-Specific Lipidation Enhancement Therapy Prime Editing Precision Correction of APOE4 to APO Selective APOE4 Degradation via Proteolysis Target (+12 more)
KG Connections	4792 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Apolipoprotein E (ApoE)

protein · 2041 words

→

Pathway Diagram

graph TD
    APOEPROTEIN["APOEPROTEIN"]
    neurodegeneration["neurodegeneration"]
    APOEPROTEIN -->|"implicated_in"| neurodegeneration
    style APOEPROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found