concept

CURCUMIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CURCUMIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

409Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	CURCUMIN
Key Genes/Proteins	MMP9, STING, MTOR, PLP1, TFEB, ROS
Related Diseases	CELL DEATH, OXIDATIVE STRESS, INFLAMMATION, AUTOPHAGY, NEUROGENESIS

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    CURCUMIN["CURCUMIN"]
    CURCUMIN -->|"treats"| Gastric_Cancer["Gastric Cancer"]
    CURCUMIN -->|"activates"| Ferroptosis["Ferroptosis"]
    CURCUMIN -->|"activates"| Autophagy["Autophagy"]
    CURCUMIN -->|"inhibits"| PI3K_AKT_mTOR_Signaling_Pathwa["PI3K/AKT/mTOR Signaling Pathway"]
    CURCUMIN -->|"inhibits"| Inflammation["Inflammation"]
    CURCUMIN -->|"inhibits"| Oxidative_Stress["Oxidative Stress"]
    CURCUMIN -->|"treats"| Intestinal_Barrier_Injury["Intestinal Barrier Injury"]
    CURCUMIN -->|"inhibits"| reactive_oxygen_species["reactive oxygen species"]
    Ampk_Tfeb["Ampk-Tfeb"] -->|"mediates"| CURCUMIN
    APOPTOSIS["APOPTOSIS"] -->|"activates"| CURCUMIN
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"activates"| CURCUMIN
    AGING["AGING"] -->|"activates"| CURCUMIN
    CANCER["CANCER"] -->|"activates"| CURCUMIN
    ATG5["ATG5"] -->|"activates"| CURCUMIN
    ATG7["ATG7"] -->|"activates"| CURCUMIN

Outgoing (273)

Target	Relation	Type	Str
MMP9	targets	protein	0.85
MINOCYCLINE	targets	drug	0.65
STING	activates	gene	0.65
MTOR	activates	gene	0.65
MMP9	interacts_with	gene	0.65
PLP1	interacts_with	gene	0.65
TFEB	promotes	gene	0.65
ROS	protects_against	gene	0.65
STING	protects_against	gene	0.65
CELL DEATH	inhibits	phenotype	0.65
ACSL4	regulates	gene	0.65
OXIDATIVE STRESS	treats	phenotype	0.65
INFLAMMATION	treats	phenotype	0.65
AUTOPHAGY	treats	phenotype	0.65
NEUROGENESIS	protects_against	phenotype	0.65
ROS	causes	phenotype	0.65
ATHEROSCLEROSIS	treats	disease	0.65
TH	protects_against	gene	0.65
WHITE MATTER	treats	brain_region	0.65
MICROGLIA	regulates	cell_type	0.65
JAK2	activates	gene	0.65
JAK2	regulates	gene	0.65
STROKE	treats	disease	0.65
SENESCENCE	regulates	phenotype	0.65
SENESCENCE	protects_against	phenotype	0.65
NEURONS	treats	cell_type	0.65
NEUROINFLAMMATION	protects_against	phenotype	0.65
NLRP3	regulates	gene	0.65
NEUROPATHY	activates	disease	0.65
DIABETIC NEUROPATHY	activates	disease	0.65
DEPRESSION	protects_against	disease	0.65
SPINAL CORD	inhibits	brain_region	0.65
AGING	regulates	phenotype	0.65
FERROPTOSIS	participates_in	phenotype	0.55
FERROPTOSIS	implicated_in	phenotype	0.55
OXIDATIVE STRESS	activates	process	0.50
TFEB	activates	gene	0.50
ROS	activates	protein	0.50
AMYLOID	associated_with	protein	0.50
TH	associated_with	gene	0.50
DOPAMINE	associated_with	phenotype	0.50
NEURONS	associated_with	cell_type	0.50
MTOR	associated_with	gene	0.45
ATG5	associated_with	gene	0.45
ATG7	associated_with	gene	0.45
SLC7A11	associated_with	gene	0.45
ACSL4	associated_with	gene	0.45
GPX4	associated_with	gene	0.45
ROS	associated_with	phenotype	0.45
TREM2	associated_with	gene	0.45

Incoming (136)

Source	Relation	Type	Str
CANCER	treats	disease	0.65
ATG5	promotes	gene	0.65
ATG7	promotes	gene	0.65
ALZHEIMER	treats	disease	0.65
ALZHEIMER'S DISEASE	treats	disease	0.65
STROKE	treats	disease	0.65
RAPAMYCIN	implicated_in	drug	0.55
mitophagy	activates	pathway	0.50
oxidative stress	activates	phenotype	0.50
oxidative stress	associated_with	phenotype	0.50
disease	regulates	disease	0.50
aging	associated_with	phenotype	0.50
Neurodegeneration	associated_with	disease	0.50
aging	activates	phenotype	0.50
Pi3K	activates	pathway	0.50
Autophagy	activates	process	0.50
mTOR	activates	entity	0.50
cancer	activates	disease	0.50
ferroptosis	activates	phenotype	0.50
Pi3K/Akt	activates	pathway	0.50
Gastric Cancer	activates	disease	0.50
PI3K/AKT/mTOR	activates	pathway	0.50
MTOR SIGNALING	activates	concept	0.50
cancer	associated_with	disease	0.50
TUMOR	associated_with	disease	0.50
TUMOR	regulates	disease	0.50
ferroptosis	regulates	phenotype	0.50
Gastric Cancer	associated_with	disease	0.50
CELL DEATH	activates	concept	0.50
LC3B	activates	protein	0.50
Pi3K	inhibits	pathway	0.50
mTOR	inhibits	entity	0.50
ferroptosis	inhibits	phenotype	0.50
apoptosis	activates	process	0.50
NF-κB	activates	concept	0.50
Rheumatoid Arthritis	activates	disease	0.50
TGFB1	regulates	gene	0.50
TNFA	regulates	gene	0.50
C3AR1	regulates	gene	0.50
Nf-Kb	regulates	pathway	0.50
aplp1	interacts_with	gene	0.50
MMP9	interacts_with	gene	0.50
CLDN5	interacts_with	gene	0.50
Sod1	interacts_with	gene	0.50
NATURAL COMPOUNDS	interacts_with	concept	0.50
Proteins	interacts_with	protein	0.50
inflammation	activates	pathway	0.50
ERK1	inhibits	gene	0.50
Autophagy	inhibits	process	0.50
oxidative stress	inhibits	phenotype	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CURCUMIN

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Progressive Supranuclear Palsy (PSP)

Parkinson's Disease

CBS/PSP Supplements Guide

CBS/PSP Rehabilitation Master Guide

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

PD Combination Therapy Matrix

Neuroresilience Mechanisms and Evidence

Therapeutics

NPM1 Gene

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

neuroinflammation

CBS/PSP Treatment Rankings

Autophagy Mechanisms

Blood-Brain Barrier Dysfunction in Neurodegeneration

Mitophagy Pathway in Neurodegeneration

omega-3-fatty-acids-neurodegeneration