gene

NCF1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NCF1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

101Connections
0Hypotheses
0Analyses
50Outgoing
42Incoming

Summary

NCF1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, activates. Associated with Diabetes, Hepatitis, Inflammation. Connected to 43 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolNCF1
Full NameNeutrophil Cytosolic Factor 1 (p47^phox^)
AliasesNeutrophil Cytosolic Factor 1
Chromosome7q11.23
Protein TypeEnzyme
FunctionNCF1 encodes the p47^phox^ subunit, a critical organizer of the NADPH oxidase complex.
Primary Expressionmicroglia, the resident immune cells of the brain
Amino Acids340 aa
PathwaysApoptosis, Ferroptosis, Toll-Like Receptor
UniProt IDP14598
NCBI Gene ID4748
Ensembl IDENSG00000158517
OMIM608512
GeneCardsNCF1
Human Protein AtlasNCF1
Associated DiseasesAlzheimer, Diabetes, Inflammation, Neuroinflammation, Parkinson
InteractionsTLR4, TNF, TREM2, ANG, Rb, INFLAMMATION
KG Connections101 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: NCF1 — AlphaFold P14598 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (9)

Knowledge base pages for this entity

Canonical Page

NCF1 — Neutrophil Cytosolic Factor 1

gene · 564 words

NCF4 (Neutrophil Cytosolic Factor 4)

gene · 2227 words

NOX2 Gene

gene · 1989 words

NOXO1 Protein

protein · 753 words

ATOX1 - Copper Chaperone

gene · 697 words

p67phox Protein

protein · 575 words

Pathway Diagram

graph TD
    NCF1["<b>NCF1</b>"]
    Inflammation{"Inflammation"}
    NCF1 -->|"therapeutic target"| Inflammation
    Ms{"Ms"}
    NCF1 -->|"therapeutic target"| Ms
    Parkinson{"Parkinson"}
    NCF1 -->|"therapeutic target"| Parkinson
    Diabetes{"Diabetes"}
    NCF1 -->|"therapeutic target"| Diabetes
    NCF1 -->|"associated with"| Parkinson
    NCF1 -->|"associated with"| Inflammation
    NCF1 -->|"associated with"| Diabetes
    Oxidative_Stress(["Oxidative Stress"])
    NCF1 -->|"therapeutic target"| Oxidative_Stress
    VIM["VIM"]
    NCF1 -->|"associated with"| VIM
    MMP9["MMP9"]
    NCF1 -->|"associated with"| MMP9
    CDC42["CDC42"]
    NCF1 -->|"associated with"| CDC42
    RAC1["RAC1"]
    NCF1 -->|"therapeutic target"| RAC1
    SOD2["SOD2"]
    SOD2 -->|"associated with"| NCF1
    CDC42 -->|"associated with"| NCF1
    CYCS["CYCS"]
    CYCS -->|"associated with"| NCF1
    GFAP["GFAP"]
    GFAP -->|"associated with"| NCF1
    RAC1 -->|"therapeutic target"| NCF1
    MET["MET"]
    MET -->|"therapeutic target"| NCF1
    MMP9 -->|"associated with"| NCF1
    VIM -->|"associated with"| NCF1
    TPM2["TPM2"]
    TPM2 -->|"therapeutic target"| NCF1
    GENES["GENES"]
    GENES -->|"associated with"| NCF1
    TPM2 -->|"associated with"| NCF1
    RAC1 -->|"associated with"| NCF1
    style NCF1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (59)

TargetRelationTypeStr
DNA Single-Strand Breaksregulatesbiomarker0.75
Inflammationtherapeutic_targetdisease0.65
Mstherapeutic_targetdisease0.65
Parkinsontherapeutic_targetdisease0.65
Diabetestherapeutic_targetdisease0.65

Incoming (42)

SourceRelationTypeStr
ATOX1upregulatesgene0.80
SOD2associated_withgene0.60
CDC42associated_withgene0.60
CYCSassociated_withgene0.60
GFAPassociated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found