Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NCF1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
NCF1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, activates. Associated with Diabetes, Hepatitis, Inflammation. Connected to 43 entities in the SciDEX knowledge graph.
| Gene Symbol | NCF1 |
| Full Name | Neutrophil Cytosolic Factor 1 (p47^phox^) |
| Aliases | Neutrophil Cytosolic Factor 1 |
| Chromosome | 7q11.23 |
| Protein Type | Enzyme |
| Function | NCF1 encodes the p47^phox^ subunit, a critical organizer of the NADPH oxidase complex. |
| Primary Expression | microglia, the resident immune cells of the brain |
| Amino Acids | 340 aa |
| Pathways | Apoptosis, Ferroptosis, Toll-Like Receptor |
| UniProt ID | P14598 |
| NCBI Gene ID | 4748 |
| Ensembl ID | ENSG00000158517 |
| OMIM | 608512 |
| GeneCards | NCF1 |
| Human Protein Atlas | NCF1 |
| Associated Diseases | Alzheimer, Diabetes, Inflammation, Neuroinflammation, Parkinson |
| Interactions | TLR4, TNF, TREM2, ANG, Rb, INFLAMMATION |
| KG Connections | 101 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
NCF1["<b>NCF1</b>"]
Inflammation{"Inflammation"}
NCF1 -->|"therapeutic target"| Inflammation
Ms{"Ms"}
NCF1 -->|"therapeutic target"| Ms
Parkinson{"Parkinson"}
NCF1 -->|"therapeutic target"| Parkinson
Diabetes{"Diabetes"}
NCF1 -->|"therapeutic target"| Diabetes
NCF1 -->|"associated with"| Parkinson
NCF1 -->|"associated with"| Inflammation
NCF1 -->|"associated with"| Diabetes
Oxidative_Stress(["Oxidative Stress"])
NCF1 -->|"therapeutic target"| Oxidative_Stress
VIM["VIM"]
NCF1 -->|"associated with"| VIM
MMP9["MMP9"]
NCF1 -->|"associated with"| MMP9
CDC42["CDC42"]
NCF1 -->|"associated with"| CDC42
RAC1["RAC1"]
NCF1 -->|"therapeutic target"| RAC1
SOD2["SOD2"]
SOD2 -->|"associated with"| NCF1
CDC42 -->|"associated with"| NCF1
CYCS["CYCS"]
CYCS -->|"associated with"| NCF1
GFAP["GFAP"]
GFAP -->|"associated with"| NCF1
RAC1 -->|"therapeutic target"| NCF1
MET["MET"]
MET -->|"therapeutic target"| NCF1
MMP9 -->|"associated with"| NCF1
VIM -->|"associated with"| NCF1
TPM2["TPM2"]
TPM2 -->|"therapeutic target"| NCF1
GENES["GENES"]
GENES -->|"associated with"| NCF1
TPM2 -->|"associated with"| NCF1
RAC1 -->|"associated with"| NCF1
style NCF1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| DNA Single-Strand Breaks | regulates | biomarker | 0.75 |
| Inflammation | therapeutic_target | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| Parkinson | therapeutic_target | disease | 0.65 |
| Diabetes | therapeutic_target | disease | 0.65 |
| Parkinson | associated_with | disease | 0.65 |
| Inflammation | associated_with | disease | 0.65 |
| Diabetes | associated_with | disease | 0.65 |
| Hepatitis | activates | disease | 0.65 |
| Inflammation | activates | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| Neuroinflammation | associated_with | disease | 0.65 |
| VIM | associated_with | gene | 0.60 |
| MMP9 | associated_with | gene | 0.60 |
| CDC42 | associated_with | gene | 0.60 |
| RAC1 | therapeutic_target | gene | 0.60 |
| CYCS | associated_with | gene | 0.60 |
| SOD2 | associated_with | gene | 0.60 |
| TLR4 | activates | gene | 0.60 |
| GFAP | associated_with | gene | 0.60 |
| RAC1 | associated_with | gene | 0.60 |
| TPM2 | therapeutic_target | gene | 0.60 |
| MET | therapeutic_target | gene | 0.60 |
| LPL | associated_with | gene | 0.60 |
| TNF | activates | gene | 0.60 |
| TREM2 | activates | gene | 0.60 |
| CX3CR1 | associated_with | gene | 0.60 |
| Rb | associated_with | protein | 0.60 |
| ANG | activates | gene | 0.60 |
| Rb | activates | protein | 0.60 |
| TH | associated_with | gene | 0.60 |
| Oxidative Stress | therapeutic_target | pathway | 0.60 |
| Oxidative Stress | associated_with | pathway | 0.60 |
| DENND3 | associated_with | gene | 0.60 |
| INFLAMMATION | activates | gene | 0.60 |
| FERROPTOSIS | activates | gene | 0.60 |
| Ferroptosis | activates | pathway | 0.60 |
| Toll-Like Receptor | activates | pathway | 0.60 |
| INFLAMMATION | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| PARKINSON'S DISEASE | associated_with | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| PARKINSON | associated_with | gene | 0.60 |
| DIABETES MELLITUS | associated_with | gene | 0.60 |
| PARKINSON | therapeutic_target | gene | 0.60 |
| MGA | therapeutic_target | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| MICROGLIA | associated_with | gene | 0.60 |
| Microglia | associated_with | cell_type | 0.60 |
| DENND3 | therapeutic_target | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ATOX1 | upregulates | gene | 0.80 |
| SOD2 | associated_with | gene | 0.60 |
| CDC42 | associated_with | gene | 0.60 |
| CYCS | associated_with | gene | 0.60 |
| GFAP | associated_with | gene | 0.60 |
| RAC1 | therapeutic_target | gene | 0.60 |
| MET | therapeutic_target | gene | 0.60 |
| MMP9 | associated_with | gene | 0.60 |
| VIM | associated_with | gene | 0.60 |
| TPM2 | therapeutic_target | gene | 0.60 |
| TPM2 | associated_with | gene | 0.60 |
| RAC1 | associated_with | gene | 0.60 |
| MET | associated_with | gene | 0.60 |
| CX3CR1 | associated_with | gene | 0.60 |
| LPL | associated_with | gene | 0.60 |
| TNF | activates | gene | 0.60 |
| NRF2 | activates | gene | 0.60 |
| STING | activates | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| OXIDATIVE STRESS | associated_with | gene | 0.60 |
| DIABETES MELLITUS | associated_with | gene | 0.60 |
| PARKINSON'S DISEASE | associated_with | gene | 0.60 |
| INFLAMMATION | associated_with | gene | 0.60 |
| PARKINSON | associated_with | gene | 0.60 |
| MGA | associated_with | gene | 0.60 |
| HUB GENES | associated_with | gene | 0.60 |
| DENND3 | therapeutic_target | gene | 0.60 |
| NEUROINFLAMMATION | associated_with | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| DISEASE-ASSOCIATED MICROGLIA | associated_with | gene | 0.60 |
| NEURODEGENERATIVE DISEASES | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| ALZHEIMER'S DISEASE | associated_with | gene | 0.60 |
| DENND3 | associated_with | gene | 0.60 |
| MGA | therapeutic_target | gene | 0.60 |
| PARKINSON | therapeutic_target | gene | 0.60 |
| MICROGLIA | associated_with | gene | 0.60 |
| DNA | associated_with | gene | 0.60 |
| APOPTOSIS | regulates | gene | 0.60 |
| TREM2 | activates | gene | 0.50 |
| GFAP | co_expressed_with | gene | 0.50 |
| MMP9 | co_expressed_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||