Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MDC1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | MDC1 |
| Full Name | Mediator of DNA Damage Checkpoint 1 |
| Function | MDC1 is a key mediator protein in the DNA damage response (DDR) pathway. |
| Ensembl ID | ENSG00000137336 |
| GeneCards | MDC1 |
| Human Protein Atlas | MDC1 |
| FHA Domain | Forkhead-associated domain for protein interactions |
| BRCT Domains | Breast cancer C-terminal domains for phospho-Ser/Thr binding |
| SDT Repeats | Ser-Asp-Thr repeats for ATM phosphorylation sites |
| NBS1-Binding Region | Mediates interaction with NBS1/MRE11/RAD50 complex |
| DNA Repair Impairment | AD neurons show reduced DNA repair capacity |
| Genomic Instability | Accumulation of DNA damage in AD brain |
| Therapeutic Target | Enhancing MDC1 function may protect neurons |
| Dopaminergic Neurons | Particularly vulnerable to DNA damage |
| Mitochondrial DNA | Links to mitochondrial dysfunction in PD |
| Associated Diseases | Als, Ataxia, Infection |
| Interactions | BRCA1, RNF8, ATM, CANCER |
| KG Connections | 24 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
MDC1["<b>MDC1</b>"]
Als{"Als"}
MDC1 -->|"interacts with"| Als
Cancer{"Cancer"}
MDC1 -->|"interacts with"| Cancer
neurodegeneration["neurodegeneration"]
MDC1 -->|"implicated in"| neurodegeneration
CANCER["CANCER"]
CANCER -->|"interacts with"| MDC1
BRCA1["BRCA1"]
BRCA1 -->|"interacts with"| MDC1
RNF8["RNF8"]
RNF8 -->|"interacts with"| MDC1
ATM["ATM"]
ATM -->|"interacts with"| MDC1
style MDC1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Als | interacts_with | disease | 0.65 |
| Cancer | interacts_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Infection | associated_with | disease | 0.65 |
| Ataxia | associated_with | disease | 0.65 |
| ATR | associated_with | gene | 0.60 |
| MRE11 | associated_with | gene | 0.60 |
| SYN1 | associated_with | gene | 0.60 |
| CHEK1 | associated_with | gene | 0.60 |
| CHMP6 | associated_with | gene | 0.60 |
| EIF4EBP1 | associated_with | gene | 0.60 |
| SLC2A1 | associated_with | gene | 0.60 |
| MICROTUBULES | associated_with | gene | 0.60 |
| DNA | associated_with | gene | 0.60 |
| ENDOSOME | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||