Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SOD3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
SOD3 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, expressed in, protects against. Associated with Als, Amyotrophic Lateral Sclerosis, Atherosclerosis. Connected to 27 entities in the SciDEX knowledge graph.
| Gene Symbol | SOD3 |
| Full Name | sod3 |
| Aliases | EC-SOD |
| Chromosome | 4p15.2 |
| Protein Type | Gene |
| Function | is a copper- and zinc-containing enzyme (Cu/ZnSOD) that is secreted into the extracellular space and the extracellular matrix [1]. |
| Primary Expression | neurons, astrocytes, and particularly in vascular endothelial cells - Lungs: Highest expression in lung tissue - Heart |
| Molecular Weight | 135 kDa |
| Amino Acids | 366 aa |
| Exons | 5 |
| NCBI Gene ID | Search NCBI |
| GeneCards | SOD3 |
| Human Protein Atlas | SOD3 |
| Associated Diseases | Amyotrophic Lateral Sclerosis |
| Interactions | ERK1, APOE, C/EBPβ, SOD1, SOD2, HO1 |
| KG Connections | 44 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
Knowledge base pages for this entity
graph TD
SOD3["<b>SOD3</b>"]
superoxide_anion["superoxide anion"]
SOD3 -->|"inhibits"| superoxide_anion
Diabetes{"Diabetes"}
SOD3 -->|"inhibits"| Diabetes
Fibrosis{"Fibrosis"}
SOD3 -->|"inhibits"| Fibrosis
Als{"Als"}
SOD3 -->|"inhibits"| Als
Cardiovascular{"Cardiovascular"}
SOD3 -->|"inhibits"| Cardiovascular
Inflammation{"Inflammation"}
SOD3 -->|"inhibits"| Inflammation
SOD3 -->|"activates"| Als
Hypertension{"Hypertension"}
SOD3 -->|"protects against"| Hypertension
Atherosclerosis{"Atherosclerosis"}
SOD3 -->|"protects against"| Atherosclerosis
SOD3 -->|"protects against"| Cardiovascular
Ms{"Ms"}
SOD3 -->|"activates"| Ms
Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
SOD3 -->|"associated with"| Amyotrophic_Lateral_Sclerosis
ERK["ERK"]
ERK -->|"expressed in"| SOD3
SOD2["SOD2"]
SOD2 -->|"expressed in"| SOD3
EGFR["EGFR"]
EGFR -->|"expressed in"| SOD3
SOD1["SOD1"]
SOD1 -->|"activates"| SOD3
SOD2 -->|"activates"| SOD3
SOD1 -->|"expressed in"| SOD3
style SOD3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| superoxide anion | inhibits | phenotype | 0.95 |
| extracellular ROS | inhibits | process | 0.95 |
| cartilage extracellular matrix | preserves | phenotype | 0.90 |
| osteoarthritis | protects_against | disease | 0.90 |
| APOE | inhibits | gene | 0.85 |
| C/EBPβ | interacts_with | protein | 0.80 |
| Diabetes | inhibits | disease | 0.65 |
| Fibrosis | inhibits | disease | 0.65 |
| Als | inhibits | disease | 0.65 |
| Cardiovascular | inhibits | disease | 0.65 |
| Inflammation | inhibits | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Hypertension | protects_against | disease | 0.65 |
| Atherosclerosis | protects_against | disease | 0.65 |
| Cardiovascular | protects_against | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Amyotrophic Lateral Sclerosis | associated_with | disease | 0.65 |
| ALS | inhibits | disease | 0.65 |
| ERK1 | inhibits | gene | 0.60 |
| NRF2 | expressed_in | gene | 0.60 |
| SOD1 | expressed_in | gene | 0.60 |
| SOD2 | expressed_in | gene | 0.60 |
| EGFR | expressed_in | gene | 0.60 |
| Oxidative Stress | inhibits | pathway | 0.60 |
| Tgf-Β | expressed_in | pathway | 0.60 |
| Oxidative Stress | protects_against | pathway | 0.60 |
| Angiogenesis | protects_against | pathway | 0.60 |
| AMYOTROPHIC LATERAL SCLEROSIS | associated_with | gene | 0.60 |
| TGF | expressed_in | gene | 0.60 |
| NF-kB signaling | participates_in | pathway | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| TGF-beta signaling | participates_in | pathway | 0.60 |
| neurons | expressed_in | cell_type | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||