gene

SOD3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SOD3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

44Connections
0Hypotheses
0Analyses
33Outgoing
11Incoming

Summary

SOD3 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, expressed in, protects against. Associated with Als, Amyotrophic Lateral Sclerosis, Atherosclerosis. Connected to 27 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolSOD3
Full Namesod3
AliasesEC-SOD
Chromosome4p15.2
Protein TypeGene
Functionis a copper- and zinc-containing enzyme (Cu/ZnSOD) that is secreted into the extracellular space and the extracellular matrix [1].
Primary Expressionneurons, astrocytes, and particularly in vascular endothelial cells - Lungs: Highest expression in lung tissue - Heart
Molecular Weight135 kDa
Amino Acids366 aa
Exons5
NCBI Gene IDSearch NCBI
GeneCardsSOD3
Human Protein AtlasSOD3
Associated DiseasesAmyotrophic Lateral Sclerosis
InteractionsERK1, APOE, C/EBPβ, SOD1, SOD2, HO1
KG Connections44 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Wiki Pages (18)

Knowledge base pages for this entity

Canonical Page

SOD3 Gene

gene · 1148 words

Progressive Supranuclear Palsy (PSP)

disease · 12907 words

NRF2 Oxidative Stress Pathway

mechanism · 5315 words

dimethyl-fumarate-nrf2-ad-nct06850597

clinical_trial · 4373 words

Oxidative Stress in Neurodegeneration

mechanism · 3216 words

Reactive Oxygen Species (ROS) Pathway

mechanism · 3211 words

Pathway Diagram

graph TD
    SOD3["<b>SOD3</b>"]
    superoxide_anion["superoxide anion"]
    SOD3 -->|"inhibits"| superoxide_anion
    Diabetes{"Diabetes"}
    SOD3 -->|"inhibits"| Diabetes
    Fibrosis{"Fibrosis"}
    SOD3 -->|"inhibits"| Fibrosis
    Als{"Als"}
    SOD3 -->|"inhibits"| Als
    Cardiovascular{"Cardiovascular"}
    SOD3 -->|"inhibits"| Cardiovascular
    Inflammation{"Inflammation"}
    SOD3 -->|"inhibits"| Inflammation
    SOD3 -->|"activates"| Als
    Hypertension{"Hypertension"}
    SOD3 -->|"protects against"| Hypertension
    Atherosclerosis{"Atherosclerosis"}
    SOD3 -->|"protects against"| Atherosclerosis
    SOD3 -->|"protects against"| Cardiovascular
    Ms{"Ms"}
    SOD3 -->|"activates"| Ms
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    SOD3 -->|"associated with"| Amyotrophic_Lateral_Sclerosis
    ERK["ERK"]
    ERK -->|"expressed in"| SOD3
    SOD2["SOD2"]
    SOD2 -->|"expressed in"| SOD3
    EGFR["EGFR"]
    EGFR -->|"expressed in"| SOD3
    SOD1["SOD1"]
    SOD1 -->|"activates"| SOD3
    SOD2 -->|"activates"| SOD3
    SOD1 -->|"expressed in"| SOD3
    style SOD3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (33)

TargetRelationTypeStr
superoxide anioninhibitsphenotype0.95
extracellular ROSinhibitsprocess0.95
cartilage extracellular matrixpreservesphenotype0.90
osteoarthritisprotects_againstdisease0.90
APOEinhibitsgene0.85

Incoming (11)

SourceRelationTypeStr
ATOX1upregulatesgene0.80
SOD2expressed_ingene0.60
EGFRexpressed_ingene0.60
SOD1activatesgene0.60
SOD2activatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found