protein

DJ-1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DJ-1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

597Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

DJ-1 (PARK7) protein: structure, function, and role in Parkinson's disease and oxidative stress response

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🔬 Protein Info

Gene Symbol	DJ
Function	Dj 1 Protein (Park7) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
GeneCards	DJ
Human Protein Atlas	DJ
Associated Diseases	Aging, Als, Alzheimer, Ataxia, disease
Interactions	6-OHDA, ACSL4, Alpha-Synuclein, ALPHA-SYNUCLEIN, ALZHEIMER, ALZHEIMER'S DISEASE
KG Connections	597 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (13)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    DJ_1["DJ-1"]
    DJ_1 -.protects against.-> Dementia["Dementia"]
    DJ_1 -->|"regulates"| mitochondrial_function["mitochondrial function"]
    DJ_1 -->|"activates"| Nrf2["Nrf2"]
    DJ_1 -->|"target for"| Parkinson["Parkinson"]
    DJ_1 -->|"target for"| Ms["Ms"]
    DJ_1 -->|"target for"| Neurodegeneration["Neurodegeneration"]
    DJ_1 -->|"target for"| Aging["Aging"]
    DJ_1 -->|"interacts"| Als["Als"]
    DJ_1 -->|"activates"| Alzheimer["Alzheimer"]
    NRF2["NRF2"] -->|"activates"| DJ_1
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"target for"| DJ_1
    PINK1["PINK1"] -->|"activates"| DJ_1
    ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"] -->|"target for"| DJ_1
    NEURODEGENERATION["NEURODEGENERATION"] -->|"target for"| DJ_1
    PARKIN["PARKIN"] -->|"activates"| DJ_1
    LRRK2["LRRK2"] -->|"target for"| DJ_1
    POLG["POLG"] -->|"target for"| DJ_1
    MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"] -->|"target for"| DJ_1
    PTEN["PTEN"] -->|"activates"| DJ_1

Outgoing (400)

Target	Relation	Type	Str
Ferroptosis	inhibits	process	0.85
Parkinson	associated_with	disease	0.85
Dementia	protects_against	disease	0.80
brain-derived extracellular vesicles	expressed_in	compound	0.80
Oxidative Stress Response	regulates	process	0.78
Microglial Autophaxy and Phagocytosis	contributes_to	process	0.75
Parkinson	expressed_in	disease	0.75
Parkinson	therapeutic_target	disease	0.75
Parkinson's disease	associated_with	disease	0.70
mitochondrial dysfunction	associated_with	process	0.70
Nrf2	activates	transcription_factor	0.70
mitochondrial function	regulates	process	0.70
LRRK2	associated_with	gene	0.70
PARKIN	associated_with	gene	0.70
PARKINSON	activates	gene	0.70
Oxidative Stress	regulates	pathway	0.70
Mitochondrial Homeostasis	regulates	process	0.70
Chaperone	regulates	pathway	0.70
Neuroinflammation	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Ataxia	associated_with	disease	0.65
Parkinson	inhibits	disease	0.65
Ms	associated_with	disease	0.65
Als	associated_with	disease	0.65
Aging	causes	disease	0.65
Neurodegeneration	biomarker_for	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Multiple Sclerosis	regulates	disease	0.65
Pain	activates	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Als	biomarker_for	disease	0.65
ALS	associated_with	disease	0.65
ALS	activates	disease	0.65
ALS	inhibits	disease	0.65
Parkinson	causes	disease	0.65
Neurodegeneration	causes	disease	0.65
Parkinson	biomarker_for	disease	0.65
Huntington	associated_with	disease	0.65
Inflammation	activates	disease	0.65
Depression	regulates	disease	0.65
Ms	causes	disease	0.65
Retinitis Pigmentosa	activates	disease	0.65
Alzheimer	inhibits	disease	0.65
Autism	regulates	disease	0.65
Tumor	activates	disease	0.65
Inflammation	associated_with	disease	0.65
Ms	inhibits	disease	0.65
Alzheimer	regulates	disease	0.65
Als	causes	disease	0.65
Ms	expressed_in	disease	0.65

Incoming (197)

Source	Relation	Type	Str
HIF-1Α/SIMA	interacts_with	protein	0.80
PARKINSON	associated_with	gene	0.80
PARKINSON'S DISEASE	therapeutic_target	gene	0.70
OXIDATIVE STRESS	regulates	gene	0.70
PARKINSON'S DISEASE	expressed_in	gene	0.70
PARKINSON'S DISEASE	associated_with	gene	0.70
PARKINSON	expressed_in	gene	0.70
PPAR	activates	gene	0.70
ATP13A2	therapeutic_target	gene	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
PARKIN	associated_with	gene	0.60
LRRK2	associated_with	gene	0.60
CANCER	activates	gene	0.60
PARKINSON	regulates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
EXERCISE	activates	gene	0.60
NRF1	activates	gene	0.60
MITOCHONDRIAL DNA	activates	gene	0.60
6-OHDA	regulates	gene	0.60
FERROPORTIN	activates	gene	0.60
PARKINSON'S DISEASE	regulates	gene	0.60
APOPTOSIS	activates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
PRKN	associated_with	gene	0.60
SNCA	associated_with	gene	0.60
TNF-Α	activates	gene	0.60
MICROGLIA	activates	gene	0.60
FTL	expressed_in	gene	0.60
ALPHA-SYNUCLEIN	regulates	gene	0.60
TNF	activates	gene	0.60
PGK1	expressed_in	gene	0.60
PINK1	associated_with	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
NEURODEGENERATIVE DISORDERS	implicated_in	gene	0.60
GENES	associated_with	gene	0.60
ALZHEIMER'S DISEASE	implicated_in	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
PRKN	expressed_in	gene	0.60
SLC7A11	expressed_in	gene	0.60
ACSL4	expressed_in	gene	0.60
FTH1	expressed_in	gene	0.60
GPX4	expressed_in	gene	0.60
APP/PS1	treats	gene	0.60
OXIDATIVE STRESS	treats	gene	0.60
ALZHEIMER	treats	gene	0.60
FERROPTOSIS	activates	gene	0.60
NRF2	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	treats	gene	0.60
APP	treats	gene	0.60
LRRK2	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DJ-1 in their description or question text

No additional research found

DJ-1

Understanding Entity Pages

Summary

Wiki Pages (13)

DJ-1 Oxidative Stress Response Pathway in Parkinson's Disease

PARK7 — Parkinsonism Associated Deglycase (DJ-1)

DJ-1-PTEN-P53 Network

PARK7 (DJ-1) Targeted Therapy for Parkinson's Disease

DJ-1 Protein

DJ-1/PARK7 Neuroprotection Pathway in Parkinson's Disease

PARK7/DJ-1 Neuroprotection Pathway — Parkinson's Disease Causal Chain

PARK7 — Parkinsonism Associated Deglycase (DJ-1)

DJ-1 Protein (PARK7)

PARK7 Gene - DJ-1/PARK7

DJ-1 (PARK7) Neuroprotective Therapies

PARK7 (DJ-1) Protein

PARK7 Protein (DJ-1)