protein

DJ-1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DJ-1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

606Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

DJ-1 (PARK7) protein: structure, function, and role in Parkinson's disease and oxidative stress response

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🔬 Protein Info

Gene Symbol	DJ
Function	Dj 1 Protein (Park7) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
GeneCards	DJ
Human Protein Atlas	DJ
Associated Diseases	ALS, Aging, Alzheimer, Ataxia, Huntington
Interactions	MITOCHONDRIAL DYSFUNCTION, MITOPHAGY, SIRT1, MTDNA, AMPK, NRF2
KG Connections	606 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    DJ_1["DJ-1"]
    DJ_1 -.protects against.-> Dementia["Dementia"]
    DJ_1 -->|"regulates"| mitochondrial_function["mitochondrial function"]
    DJ_1 -->|"activates"| Nrf2["Nrf2"]
    DJ_1 -->|"target for"| Parkinson["Parkinson"]
    DJ_1 -->|"target for"| Ms["Ms"]
    DJ_1 -->|"target for"| Neurodegeneration["Neurodegeneration"]
    DJ_1 -->|"target for"| Aging["Aging"]
    DJ_1 -->|"interacts"| Als["Als"]
    DJ_1 -->|"activates"| Alzheimer["Alzheimer"]
    NRF2["NRF2"] -->|"activates"| DJ_1
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"target for"| DJ_1
    PINK1["PINK1"] -->|"activates"| DJ_1
    ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"] -->|"target for"| DJ_1
    NEURODEGENERATION["NEURODEGENERATION"] -->|"target for"| DJ_1
    PARKIN["PARKIN"] -->|"activates"| DJ_1
    LRRK2["LRRK2"] -->|"target for"| DJ_1
    POLG["POLG"] -->|"target for"| DJ_1
    MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"] -->|"target for"| DJ_1
    PTEN["PTEN"] -->|"activates"| DJ_1

Outgoing (405)

Target	Relation	Type	Str
Parkinson	associated_with	disease	0.85
Ferroptosis	inhibits	process	0.85
Dementia	protects_against	disease	0.80
brain-derived extracellular vesicles	expressed_in	compound	0.80
Oxidative Stress Response	regulates	process	0.78
Parkinson	therapeutic_target	disease	0.75
Parkinson	expressed_in	disease	0.75
Microglial Autophaxy and Phagocytosis	contributes_to	process	0.75
Parkinson's disease	associated_with	disease	0.70
mitochondrial dysfunction	associated_with	process	0.70
mitochondrial function	regulates	process	0.70
Nrf2	activates	transcription_factor	0.70
LRRK2	associated_with	gene	0.70
PARKINSON	activates	gene	0.70
PARKIN	associated_with	gene	0.70
Oxidative Stress	regulates	pathway	0.70
Chaperone	regulates	pathway	0.70
Mitochondrial Homeostasis	regulates	biological_process	0.70
Ms	therapeutic_target	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Als	interacts_with	disease	0.65
Ms	expressed_in	disease	0.65
Alzheimer	activates	disease	0.65
Neuropathy	activates	disease	0.65
Obesity	activates	disease	0.65
Diabetes	activates	disease	0.65
Stroke	activates	disease	0.65
Als	activates	disease	0.65
Epilepsy	activates	disease	0.65
Huntington	activates	disease	0.65
Cancer	activates	disease	0.65
Parkinson	activates	disease	0.65
Ms	activates	disease	0.65
Ataxia	activates	disease	0.65
Parkinson	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Tumor	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Tumor	expressed_in	disease	0.65
Cancer	therapeutic_target	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Alzheimer	implicated_in	disease	0.65
Type 2 Diabetes	activates	disease	0.65
Insulin Resistance	activates	disease	0.65
Alzheimer	treats	disease	0.65
Depression	treats	disease	0.65

Incoming (201)

Source	Relation	Type	Str
HIF-1Α/SIMA	interacts_with	protein	0.80
PARKINSON	associated_with	gene	0.80
PARKINSON'S DISEASE	therapeutic_target	gene	0.70
PARKINSON'S DISEASE	expressed_in	gene	0.70
PARKINSON	expressed_in	gene	0.70
PPAR	activates	gene	0.70
PARKINSON'S DISEASE	associated_with	gene	0.70
OXIDATIVE STRESS	regulates	gene	0.70
PINK1	activates	gene	0.60
ALPHA-SYNUCLEIN	therapeutic_target	gene	0.60
NEURODEGENERATION	therapeutic_target	gene	0.60
PARKIN	activates	gene	0.60
LRRK2	therapeutic_target	gene	0.60
POLG	therapeutic_target	gene	0.60
MITOCHONDRIAL DYSFUNCTION	therapeutic_target	gene	0.60
PTEN	activates	gene	0.60
SNCA	therapeutic_target	gene	0.60
AGING	therapeutic_target	gene	0.60
PINK1	interacts_with	gene	0.60
ALPHA-SYNUCLEIN	interacts_with	gene	0.60
PARKIN	interacts_with	gene	0.60
UBIQUITIN	therapeutic_target	gene	0.60
MITOPHAGY	therapeutic_target	gene	0.60
LRRK2	interacts_with	gene	0.60
OXIDATIVE STRESS	interacts_with	gene	0.60
PINK1	expressed_in	gene	0.60
LRRK2	expressed_in	gene	0.60
ATP13A2	therapeutic_target	gene	0.60
PRKN	expressed_in	gene	0.60
NRF2	inhibits	gene	0.60
PARKIN	associated_with	gene	0.60
LRRK2	associated_with	gene	0.60
CANCER	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
EXERCISE	activates	gene	0.60
NRF1	activates	gene	0.60
MITOCHONDRIAL DNA	activates	gene	0.60
6-OHDA	regulates	gene	0.60
FERROPORTIN	activates	gene	0.60
PARKINSON'S DISEASE	regulates	gene	0.60
PARKINSON	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
GAIN	expressed_in	gene	0.60
PRKN	associated_with	gene	0.60
SNCA	associated_with	gene	0.60
TNF-Α	activates	gene	0.60
MICROGLIA	activates	gene	0.60
ALPHA-SYNUCLEIN	regulates	gene	0.60
ATP13A2	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

DJ-1

Understanding Entity Pages

Summary

Wiki Pages (20)

Parkinson's Disease

neuroinflammation

Mitochondrial Quality Control

Mitochondrial Dysfunction in Parkinson's Disease

substantia-nigra

Epigenetic Dysregulation in Neurodegeneration

Curcumin for Neurodegeneration

ATP13A2 Lysosomal Dysfunction Pathway in Parkinson's Disease

Mitochondria

Calcium Signaling Dysregulation in Parkinson's Disease

Transcriptional Regulation in Neurodegeneration

Quinolinic Acid Neurotoxicity in Neurodegeneration

Calcium Signaling Dysregulation in Neurodegeneration

LRRK2 G2019S

sporadic-familial-pd-comparison

Calcium Dysregulation in Neurodegeneration

Proteostasis Network Dysfunction Comparison Across Neurodegenerative Diseases

cGAS-STING Signaling in Parkinson's Disease