Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ENDOPLASMIC RETICULUM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No summary available yet. View on Wiki →
| Name | ENDOPLASMIC RETICULUM |
| Key Genes/Proteins | G3BP1, UBIQUITIN, VALOSIN, AMBRA1, PERK, ABCD3 |
| Related Pathways | Sphingolipid, mitophagy |
Knowledge base pages for this entity
graph TD
ENDOPLASMIC_RETICULUM["ENDOPLASMIC RETICULUM"]
ENDOPLASMIC_RETICULUM -->|"activates"| Unfolded_Protein_Response["Unfolded Protein Response"]
ENDOPLASMIC_RETICULUM -->|"involved_in"| Viral_Protein_Synthesis["Viral Protein Synthesis"]
ENDOPLASMIC_RETICULUM -->|"activates"| LC3["LC3"]
ENDOPLASMIC_RETICULUM -->|"interacts"| Mitochondria["Mitochondria"]
ENDOPLASMIC_RETICULUM -->|"interacts"| Plasma_Membrane["Plasma Membrane"]
ENDOPLASMIC_RETICULUM -->|"regulates"| Calcium_Homeostasis["Calcium Homeostasis"]
ENDOPLASMIC_RETICULUM -->|"substrate_of"| Selective_Autophagy["Selective Autophagy"]
ENDOPLASMIC_RETICULUM -->|"activates"| ROS["ROS"]
Viral_Replication["Viral Replication"] -->|"involved_in"| ENDOPLASMIC_RETICULUM
AUTOPHAGY["AUTOPHAGY"] -->|"activates"| ENDOPLASMIC_RETICULUM
Reticulophagy["Reticulophagy"] -->|"targets"| ENDOPLASMIC_RETICULUM
IP3_receptor["IP3 receptor"] -->|"expressed in"| ENDOPLASMIC_RETICULUM
VAP_A["VAP-A"] -->|"involved_in"| ENDOPLASMIC_RETICULUM
BECN1["BECN1"] -->|"activates"| ENDOPLASMIC_RETICULUM
reticulophagy["reticulophagy"] -->|"regulates"| ENDOPLASMIC_RETICULUM| Target | Relation | Type | Str |
|---|---|---|---|
| AUTOPHAGOSOME | activates | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Sphingolipid | inhibits | pathway | 0.50 |
| ENDOPLASMIC RETICULUM STRESS | inhibits | concept | 0.50 |
| STEM CELLS | inhibits | concept | 0.50 |
| STEM CELLS | regulates | concept | 0.50 |
| G3BP1 | interacts_with | gene | 0.50 |
| UBIQUITIN | interacts_with | protein | 0.50 |
| VALOSIN | interacts_with | gene | 0.50 |
| Autophagy | associated_with | process | 0.50 |
| mitophagy | associated_with | pathway | 0.50 |
| NUCLEOPHAGY | associated_with | concept | 0.50 |
| AMBRA1 | activates | protein | 0.50 |
| PERK | activates | gene | 0.50 |
| ABCD3 | activates | gene | 0.50 |
| Autophagy | activates | process | 0.50 |
| STING1 | activates | protein | 0.50 |
| G3BP1 | activates | gene | 0.50 |
| EIF2AK3 | activates | gene | 0.50 |
| MAPK8 | activates | gene | 0.50 |
| LMNA | activates | gene | 0.50 |
| NDP52 | activates | gene | 0.50 |
| PTEN | activates | gene | 0.50 |
| FIP200 | activates | gene | 0.50 |
| FAM134B | activates | gene | 0.50 |
| ERN1 | activates | gene | 0.50 |
| CANX | activates | gene | 0.50 |
| BNIP3 | activates | gene | 0.50 |
| MAP1LC3B | activates | gene | 0.50 |
| SESN2 | activates | gene | 0.50 |
| DISC1 | activates | gene | 0.50 |
| PRKN | activates | gene | 0.50 |
| TAX1BP1 | activates | gene | 0.50 |
| FUNDC1 | activates | gene | 0.50 |
| RHOT1 | activates | gene | 0.50 |
| BCL2L13 | activates | gene | 0.50 |
| FMR1 | activates | gene | 0.50 |
| PEX3 | activates | gene | 0.50 |
| RB1CC1 | activates | gene | 0.50 |
| RTN3 | activates | gene | 0.50 |
| MUL1 | activates | gene | 0.50 |
| EPAS1 | activates | gene | 0.50 |
| CALCOCO2 | activates | gene | 0.50 |
| SNCAIP | activates | gene | 0.50 |
| NBR1 | activates | gene | 0.50 |
| EIF2Α | activates | protein | 0.50 |
| BNIP3L | activates | protein | 0.50 |
| OPTINEURIN | activates | protein | 0.50 |
| PRESENILIN | activates | protein | 0.50 |
| MIRO1 | activates | protein | 0.50 |
| UBIQUITIN | activates | protein | 0.50 |
| PARL | activates | protein | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||