SciDEX — Gastric Cancer

graph TD
    Gastric_Cancer["<b>Gastric Cancer</b>"]
    Apoptosis["Apoptosis"]
    Gastric_Cancer -->|"activates"| Apoptosis
    Drug_Resistance["Drug Resistance"]
    Gastric_Cancer -->|"therapeutic_target"| Drug_Resistance
    Metastasis["Metastasis"]
    Gastric_Cancer -->|"regulates"| Metastasis
    Immunotherapy["Immunotherapy"]
    Gastric_Cancer -->|"therapeutic_target"| Immunotherapy
    Epigenetic["Epigenetic"]
    Gastric_Cancer -->|"associated_with"| Epigenetic
    CANCER(["CANCER"])
    CANCER -->|"therapeutic_target"| Gastric_Cancer
    Cancer{"Cancer"}
    Cancer -->|"therapeutic_target"| Gastric_Cancer
    Als{"Als"}
    Als -->|"therapeutic_target"| Gastric_Cancer
    style Gastric_Cancer fill:#1a3a4a,stroke:#ef5350,stroke-width:3px,color:#e0e0e0

Outgoing (126)

Target	Relation	Type	Str
Apoptosis	activates	pathway	1.00
Drug Resistance	therapeutic_target	pathway	1.00
Peritoneal Metastasis	associated_with	phenotype	0.90
Metastasis	regulates	pathway	0.90
Digestive System Cancers	associated_with	disease	0.80
Immunotherapy	therapeutic_target	pathway	0.80
Epigenetic	associated_with	pathway	0.80
Epigenetic	therapeutic_target	pathway	0.80
Metastasis	activates	pathway	0.80
Invasion	activates	pathway	0.80
Mtor	therapeutic_target	pathway	0.70
Microrna	associated_with	pathway	0.70
Angiogenesis	regulates	pathway	0.70
Microrna	regulates	pathway	0.70
Invasion	expressed_in	pathway	0.70
Wnt	therapeutic_target	pathway	0.70
Autophagy	therapeutic_target	pathway	0.70
Tumor Microenvironment	therapeutic_target	pathway	0.70
Mapk	therapeutic_target	pathway	0.70
Ferroptosis	activates	pathway	0.70
Apoptosis	treats	pathway	0.70
Mismatch Repair	associated_with	pathway	0.70
Autophagy	regulates	pathway	0.60
Pi3K/Akt	therapeutic_target	pathway	0.60
Epithelial-Mesenchymal Transition	regulates	pathway	0.60
Chemoresistance	regulates	pathway	0.60
Apoptosis	regulates	pathway	0.60
Dna Methylation	regulates	pathway	0.60
Histone Modification	regulates	pathway	0.60
Epigenetic	regulates	pathway	0.60
Checkpoint Inhibitor	treats	pathway	0.60
Immune Checkpoint	treats	pathway	0.60
Dna Methylation	associated_with	pathway	0.60
Oxidative Stress	associated_with	pathway	0.60
Mtor	activates	pathway	0.60
Autophagy	inhibits	pathway	0.60
Pi3K/Akt	activates	pathway	0.60
Lipid Metabolism	inhibits	pathway	0.60
Pi3K/Akt	regulates	pathway	0.60
Apoptosis	inhibits	pathway	0.60
Notch	therapeutic_target	pathway	0.60
Metastasis	interacts_with	pathway	0.60
Lysosomal Degradation	activates	pathway	0.60
Invasion	interacts_with	pathway	0.60
Cell Cycle	regulates	pathway	0.60
Oxidative Stress	treats	pathway	0.60
Foxo Signaling	treats	pathway	0.60
Mismatch Repair	activates	pathway	0.60
Lipid Metabolism	activates	pathway	0.60
Nf-Κb	activates	pathway	0.60

Incoming (377)

Source	Relation	Type	Str
CANCER	therapeutic_target	gene	1.00
Cancer	therapeutic_target	disease	1.00
Als	therapeutic_target	disease	1.00
CANCER	associated_with	gene	1.00
Cancer	associated_with	disease	1.00
CANCER	inhibits	gene	1.00
Cancer	inhibits	disease	1.00
CANCER	activates	gene	1.00
Cancer	activates	disease	1.00
APOPTOSIS	activates	gene	1.00
Tumor	therapeutic_target	disease	1.00
HER2	associated_with	protein	0.98
ERBB2	associated_with	gene	0.98
Peritoneal Metastasis	associated_with	phenotype	0.95
OVERVIEW	therapeutic_target	gene	0.95
CANCER	regulates	gene	0.95
Tumor	associated_with	disease	0.95
Als	associated_with	disease	0.95
Tumor	activates	disease	0.95
Tumor	inhibits	disease	0.95
CANCER	expressed_in	gene	0.95
Colorectal Cancer	associated_with	disease	0.95
Chronic Atrophic Gastritis	risk_factor_for	disease	0.95
Claudin 18.2	biomarker_for	protein	0.95
Streptococcus anginosus	risk_factor_for	compound	0.95
CLDN18.2	biomarker_for	protein	0.95
Curcumin	treats	compound	0.95
CLDN18	biomarker_for	protein	0.95
Zolbetuximab	treats	drug	0.95
PI3K/AKT/mTOR	involved_in	pathway	0.95
Nobiletin	treats	compound	0.93
AURKA	associated_with	gene	0.92
PRMT1	associated_with	gene	0.90
ATP2A3	associated_with	gene	0.90
PI3K/AKT/mTOR	associated_with	pathway	0.90
Ferroptosis	involved_in	process	0.88
Ginger	treats	drug	0.85
PRMT1/BTG2 Axis	involved_in	pathway	0.85
MCOLN1	targets	protein	0.85
Caf	contributes_to	cell_type	0.85
Tumor	regulates	disease	0.85
Cancer	regulates	disease	0.85
DNA	associated_with	gene	0.85
Cancer	expressed_in	disease	0.85
EGFR	therapeutic_target	gene	0.85
DNA	therapeutic_target	gene	0.85
SERCA3	biomarker_for	protein	0.85
Hypoxia	contributes_to	process	0.85
MCOLN1	associated_with	protein	0.80
Ferroptosis	associated_with	process	0.80

Associated Genes	AURKA, MCOLN1, BAD, OXIDATIVE STRESS, RAS, INFLAMMATION, CANCER, MICRORNAS
Therapeutic Agents	Ginger, Nobiletin, Curcumin, Zolbetuximab
KG Connections	492 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Gastric Cancer

Understanding Entity Pages

Wiki Pages (20)

Litronesib (LY317615/Enzastaurin)

biocon

TRIM3

Flotillin-2 Protein

Ribosomal Protein S15a (RPS15A)

Pathway Diagram

Outgoing (126)

Incoming (377)

Targeting Hypotheses (0)

Mentioning Analyses (0)

Related Papers (0)

Gastric Cancer

Understanding Entity Pages

Wiki Pages (20)

Litronesib (LY317615/Enzastaurin)

biocon

TRIM3

Flotillin-2 Protein

Ribosomal Protein S15a (RPS15A)

PMS2 — DNA Mismatch Repair Protein PMS2

SOCS4 — Suppressor of Cytokine Signaling 4

LRRN1 — Leucine Rich Repeat Neuronal 1

PIK3CB — Phosphatidylinositol-4,5-bisphosphate 3-kinase Catalytic Subunit Beta

FZD9 Protein

NOXA Gene (PMAIP1)

EPHB3 Gene

CRKL Gene

PRKAA1

MFSD2A - Major Facilitator Superfamily Domain Containing 2A

ZCCHC10 — Zinc Finger CCHC-Type Containing 10

Syntaxin-binding protein 5

ATF2 — Activating Transcription Factor 2

AURKA Gene

MSH2 — MutS Homolog 2

Pathway Diagram

Outgoing (126)

Incoming (377)

Targeting Hypotheses (0)

Mentioning Analyses (0)

Related Papers (0)