protein

AXLPROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AXLPROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Hypotheses

0Analyses

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0Debates

Summary

In the brain, AXL is expressed in neurons, microglia, astrocytes, and vascular endothelial cells.

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🔬 Protein Info

Gene Symbol	AXLPROTEIN
Protein Type	Receptor
Function	is a member of the TAM (TYRO3, AXL, MERTK) receptor tyrosine kinase family that plays versatile roles in both normal physiology and disease pathogenesis.
Primary Expression	neurons, microglia, astrocytes, and vascular endothelial cells
Subcellular Localization	** \| Cell membrane, Endosomes, Nucleus \|
Molecular Weight	140 kDa
GeneCards	AXLPROTEIN
Human Protein Atlas	AXLPROTEIN
Proline-rich region	N-terminal segment
Single-pass α-helical membrane span	Connects extracellular and intracellular domains
Tyrosine kinase domain	Catalytic domain with ATP-binding pocket
Activation loop	Contains key tyrosine phosphorylation sites (Tyr821, Tyr824, Tyr866)
Multiple tyrosine residues	Sites for autophosphorylation and SH2 domain recruitment
Dimerization required	AXL exists as monomers that dimerize upon ligand binding
Kinase activity	Ligand-induced dimerization triggers autophosphorylation
Associated Diseases	Aging, Alzheimer, Cancer, INFLAMMATION, Ms, NEUROINFLAMMATION
Interactions	ADAM10, AGING, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND
KG Connections	202 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Axl Protein

protein · 1714 words

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Pathway Diagram

graph TD
    AXLPROTEIN["AXLPROTEIN"]
    neurodegeneration["neurodegeneration"]
    AXLPROTEIN -->|"implicated_in"| neurodegeneration
    style AXLPROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning AXLPROTEIN in their description or question text

No additional research found