protein

CASP1PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CASP1PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Once activated, caspase-1 performs two critical functions: (1) cleaving pro-interleukin-1β (pro-IL-1β) and pro-IL-18 to produce active pro-inflammatory cytokines, and (2) cleaving gasdermin D to initiate pyroptotic cell death.

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🔬 Protein Info

Gene Symbol	CASP1PROTEIN
Target Class	Protease
Function	is an inflammatory caspase encoded by the CASP1 gene that plays central roles in the innate immune response and inflammatory cell death (pyroptosis)[@martin2019].
Mechanism of Action	Small molecule covalent inhibitor of caspase-1 proteolytic activity
Subcellular Localization	** \| Cytoplasm, inflammasome complexes \|
Druggability	Medium (0.46)
Clinical Stage	Phase II
Molecular Weight	45 kDa
GeneCards	CASP1PROTEIN
Human Protein Atlas	CASP1PROTEIN
Associated Diseases	Aging, Als, ALZHEIMER, atherosclerosis
Known Drugs/Compounds	KAEMPFEROL, Pterostilbene, rapamycin
Interactions	ACTB, AGING, AIF1, AIM2, AKT3, ALZHEIMER
SciDEX Target	View Target Profile (3 clinical trials)
KG Connections	848 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Caspase-1 Protein

protein · 813 words

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Pathway Diagram

graph TD
    CASP1PROTEIN["CASP1PROTEIN"]
    neurodegeneration["neurodegeneration"]
    CASP1PROTEIN -->|"implicated_in"| neurodegeneration
    style CASP1PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning CASP1PROTEIN in their description or question text

No additional research found