| Gene Symbol | CASP1PROTEIN |
| Target Class | Protease |
| Function | is an inflammatory caspase encoded by the CASP1 gene that plays central roles in the innate immune response and inflammatory cell death (pyroptosis)[@martin2019]. |
| Mechanism of Action | Small molecule covalent inhibitor of caspase-1 proteolytic activity |
| Subcellular Localization | ** | Cytoplasm, inflammasome complexes | |
| Druggability | Medium (0.46) |
| Clinical Stage | Phase II |
| Molecular Weight | 45 kDa |
| GeneCards | CASP1PROTEIN |
| Human Protein Atlas | CASP1PROTEIN |
| Associated Diseases | Aging, Als, ALZHEIMER, atherosclerosis |
| Known Drugs/Compounds | KAEMPFEROL, Pterostilbene, rapamycin |
| Interactions | ACTB, AGING, AIF1, AIM2, AKT3, ALZHEIMER |
| SciDEX Target | View Target Profile (3 clinical trials) |
| KG Connections | 848 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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