| Gene Symbol | CASP1PROTEIN |
| Protein Family | Caspase family (inflammatory caspases) |
| Target Class | Protease |
| Function | is an inflammatory caspase encoded by the CASP1 gene that plays central roles in the innate immune response and inflammatory cell death (pyroptosis)[@martin2019]. |
| Mechanism of Action | Small molecule covalent inhibitor of caspase-1 proteolytic activity |
| Primary Expression | Primarily immune cells; low in healthy brain |
| Subcellular Localization | Cytoplasm, inflammasome complexes |
| Druggability | Medium (0.46) |
| Clinical Stage | Phase II |
| Molecular Weight | ~45 kDa (active enzyme) |
| UniProt ID | P29466 |
| GeneCards | CASP1PROTEIN |
| Human Protein Atlas | CASP1PROTEIN |
| Protein Name | Caspase-1 |
| Gene | CASP1 |
| Associated Diseases | ALS, ALZHEIMER, Aging, Atherosclerosis, Cancer |
| Known Drugs/Compounds | Pterostilbene, KAEMPFEROL, rapamycin |
| Interactions | NLRP3, IL1B, PYCARD, SNCA, ASC, SQSTM1 |
| SciDEX Target | View Target Profile (3 clinical trials) |
| KG Connections | 851 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |