Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CASP2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | CASP2 |
| Full Name | Caspase 2 (CASP2) |
| Chromosome | 7q34 |
| Protein Type | Protein |
| Function | Caspase 2 has diverse cellular functions beyond apoptosis: |
| Molecular Weight | 20 kDa |
| Amino Acids | 165 aa |
| Pathways | Cell Cycle, Dna Repair, Oxidative Stress |
| UniProt ID | Search UniProt |
| Ensembl ID | ENSG00000106144 |
| GeneCards | CASP2 |
| Human Protein Atlas | CASP2 |
| Associated Diseases | Aging, Cancer, Inflammation, Neurodegeneration |
| Interactions | UBIQUITIN, AUTOPHAGY, APOPTOSIS |
| KG Connections | 36 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
CASP2["<b>CASP2</b>"]
CASPASE2["CASPASE2"]
CASP2 -->|"encodes"| CASPASE2
APOPTOSIS["APOPTOSIS"]
CASP2 -->|"participates in"| APOPTOSIS
NUCLEUS["NUCLEUS"]
CASP2 -->|"expressed in"| NUCLEUS
TUMOR_SUPPRESSION(["TUMOR_SUPPRESSION"])
CASP2 -->|"participates in"| TUMOR_SUPPRESSION
AGING["AGING"]
CASP2 -->|"participates in"| AGING
PROTEOLYTIC_PROCESSING["PROTEOLYTIC_PROCESSING"]
CASP2 -->|"regulates"| PROTEOLYTIC_PROCESSING
CASP3["CASP3"]
CASP2 -->|"associated with"| CASP3
neurodegeneration["neurodegeneration"]
CASP2 -->|"implicated in"| neurodegeneration
DIMERIZATION["DIMERIZATION"]
DIMERIZATION -->|"activates"| CASP2
style CASP2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| ubiquitin homeostasis | regulates | process | 0.95 |
| UBIQUITIN | binds_to | protein | 0.90 |
| TARDBP | modulates | protein | 0.90 |
| CASPASE2 | encodes | protein | 0.80 |
| APOPTOSIS | participates_in | phenotype | 0.72 |
| NUCLEUS | expressed_in | cell_type | 0.72 |
| Als | regulates | disease | 0.65 |
| Inflammation | implicated_in | disease | 0.65 |
| Cancer | implicated_in | disease | 0.65 |
| Aging | implicated_in | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Neurodegeneration | implicated_in | disease | 0.65 |
| TUMOR_SUPPRESSION | participates_in | pathway | 0.64 |
| PROTEOLYTIC_PROCESSING | regulates | phenotype | 0.64 |
| AGING | participates_in | phenotype | 0.64 |
| CASP3 | associated_with | gene | 0.60 |
| UBIQUITIN | interacts_with | gene | 0.60 |
| NEURODEGENERATIVE DISEASES | regulates | gene | 0.60 |
| INFLAMMATION | implicated_in | gene | 0.60 |
| DNA | causes | gene | 0.60 |
| Apoptosis | implicated_in | pathway | 0.60 |
| Proteasome | expressed_in | pathway | 0.60 |
| CANCER | implicated_in | gene | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| AGING | implicated_in | gene | 0.60 |
| DNA | regulates | gene | 0.60 |
| Autophagy | activates | pathway | 0.60 |
| Dna Repair | regulates | pathway | 0.60 |
| Oxidative Stress | regulates | pathway | 0.60 |
| Apoptosis | activates | pathway | 0.60 |
| Cell Cycle | regulates | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| DIMERIZATION | activates | phenotype | 0.72 |
| APOPTOSIS | implicated_in | gene | 0.60 |
| APOPTOSIS | activates | gene | 0.60 |
| NEURODEGENERATION | implicated_in | gene | 0.60 |
| OXIDATIVE STRESS | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||