protein 1,169 words KG: ERN1PROTEIN 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

ERN1/IRE1 Protein — ER Stress Sensor

🔬 Protein Info
Gene SymbolERN1PROTEIN
Chromosome6p21.1.
Functionis a critical transmembrane protein that functions as a primary sensor of endoplasmic reticulum (ER) stress.
GeneCardsERN1PROTEIN
Human Protein AtlasERN1PROTEIN
[BiP/GRP78](/proteins/grp78-protein)Chaperone binding
[XBP1](/proteins/xbp1-protein)Substrate
[ASK1](/proteins/ask1-protein)Kinase cascade
[Bcl-2](/proteins/bcl2-protein)Family interaction
[JNK](/proteins/jnk-protein)Downstream kinase
[EDEM1](/proteins/edem1-protein)ERAD component
[SEL1L](/proteins/sel1l-protein)ERAD component
Associated DiseasesAD, ALI, ALS, Aging, Alzheimer
Known Drugs/Compoundsrapamycin
InteractionsPARKIN, FMR1, SNCA, FAM134B, LC3, EPAS1
KG Connections986 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph