concept

CGAS-STING SIGNALING

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CGAS-STING SIGNALING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

16Connections

0Hypotheses

0Analyses

13Outgoing

3Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	CGAS-STING SIGNALING

Wiki Pages (14)

Knowledge base pages for this entity

TBK1-Mediated Neuroinflammation Hypothesis — Autophagy Failure and Innate Immune Dysregulation in FTD/ALS

hypothesis · 2087 words

→

Pathway Diagram

graph TD
    CGAS_STING_SIGNALING["CGAS-STING SIGNALING"]
    CGAS_STING_SIGNALING -->|"involved_in"| Alzheimer_s_Disease["Alzheimer's Disease"]
    CGAS_STING_SIGNALING -->|"involved_in"| Parkinson_s_Disease["Parkinson's Disease"]
    CGAS_STING_SIGNALING -->|"involved_in"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    CGAS_STING_SIGNALING -->|"regulates"| ferroptosis["ferroptosis"]
    CGAS_STING_SIGNALING -->|"participates in"| aging["aging"]
    CGAS_STING_SIGNALING -->|"involved_in"| Tauopathies["Tauopathies"]
    CGAS_STING_SIGNALING -->|"participates in"| Alzheimer_s_disease["Alzheimer's disease"]
    CGAS_STING_SIGNALING -->|"participates in"| Parkinson_s_disease["Parkinson's disease"]
    SMARCAL1["SMARCAL1"] -->|"inhibits"| CGAS_STING_SIGNALING
    mitochondrial_DNA_release["mitochondrial DNA release"] -->|"activates"| CGAS_STING_SIGNALING
    DNA_damage["DNA damage"] -->|"activates"| CGAS_STING_SIGNALING

Outgoing (13)

Target	Relation	Type	Str
CNS Injury	associated_with	disease	0.85
Neurodegeneration	associated_with	disease	0.85
Alzheimer's Disease	involved_in	disease	0.85
Parkinson's Disease	involved_in	disease	0.85
Amyotrophic Lateral Sclerosis	involved_in	disease	0.85
senescence	associated_with	process	0.85
ferroptosis	regulates	pathway	0.80
aging	participates_in	phenotype	0.80
Aging	associated_with	process	0.80
Tauopathies	involved_in	disease	0.80
Alzheimer's disease	participates_in	disease	0.70
Parkinson's disease	participates_in	disease	0.70
amyotrophic lateral sclerosis	participates_in	disease	0.70

Incoming (3)

Source	Relation	Type	Str
SMARCAL1	inhibits	gene	0.95
mitochondrial DNA release	activates	phenotype	0.90
DNA damage	activates	process	0.90

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CGAS-STING SIGNALING

Understanding Entity Pages

Wiki Pages (14)