pathway

PI3K-AKT-mTOR signaling

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PI3K-AKT-mTOR signaling: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

396Connections

0Hypotheses

1Analyses

31Outgoing

50Incoming

0Experiments

1Debates

No summary available yet.

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🔀 Pathway Info

Name	PI3K-AKT-mTOR signaling
Key Genes/Proteins	ABCA1, ABCG1, ACE, ACLY, ACSL4, AKT
Related Diseases	aging, Alzheimer's disease
Related Pathways	AMPK signaling

Pathway Diagram

graph TD
    PI3K_AKT_mTOR_signaling["PI3K-AKT-mTOR signaling"] -->|"involved in"| Clear_Cell_Renal_Cell_Carcinom["Clear-Cell Renal Cell Carcinoma"]
    style Clear_Cell_Renal_Cell_Carcinom fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    PI3K_AKT_mTOR_signaling["PI3K-AKT-mTOR signaling"] -->|"crosstalk with"| autophagy_pathway["autophagy pathway"]
    style autophagy_pathway fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    PI3K_AKT_mTOR_signaling["PI3K-AKT-mTOR signaling"] -->|"crosstalk with"| unfolded_protein_response["unfolded protein response"]
    style unfolded_protein_response fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    PI3K_AKT_mTOR_signaling["PI3K-AKT-mTOR signaling"] -->|"active in"| microglia["microglia"]
    style microglia fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    PI3K_AKT_mTOR_signaling["PI3K-AKT-mTOR signaling"] -->|"active in"| macrophages["macrophages"]
    style macrophages fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    PI3K_AKT_mTOR_signaling["PI3K-AKT-mTOR signaling"] -->|"crosstalk with"| ferroptosis["ferroptosis"]
    style ferroptosis fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    PI3K_AKT_mTOR_signaling["PI3K-AKT-mTOR signaling"] -->|"active in"| hippocampus["hippocampus"]
    style hippocampus fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Syn3["Syn3"] -->|"activates"| PI3K_AKT_mTOR_signaling["PI3K-AKT-mTOR signaling"]
    style Syn3 fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    AKT["AKT"] -->|"participates in"| PI3K_AKT_mTOR_signaling["PI3K-AKT-mTOR signaling"]
    style AKT fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    PI3K["PI3K"] -->|"participates in"| PI3K_AKT_mTOR_signaling["PI3K-AKT-mTOR signaling"]
    style PI3K fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    MTOR["MTOR"] -->|"participates in"| PI3K_AKT_mTOR_signaling["PI3K-AKT-mTOR signaling"]
    style MTOR fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    PTEN["PTEN"] -->|"participates in"| PI3K_AKT_mTOR_signaling["PI3K-AKT-mTOR signaling"]
    style PTEN fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style PI3K_AKT_mTOR_signaling fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (31)

Target	Relation	Type	Str
microglia	active_in	cell_type	0.90
macrophages	active_in	cell_type	0.90
neural stem cells	active_in	cell_type	0.90
autophagy pathway	inhibits	pathway	0.90
ferroptosis	mediates	process	0.90
Clear-Cell Renal Cell Carcinoma	involved_in	disease	0.90
unfolded protein response	crosstalk_with	pathway	0.90
autophagy pathway	crosstalk_with	pathway	0.90
ferroptosis	crosstalk_with	pathway	0.90
blood-brain barrier	active_in	brain_region	0.80
hippocampus	active_in	brain_region	0.80
cortex	active_in	brain_region	0.80
neurons	active_in	cell_type	0.80
lipid metabolism	crosstalk_with	pathway	0.80
insulin signaling	crosstalk_with	pathway	0.70
TGF-beta signaling	crosstalk_with	pathway	0.70
endothelial cells	active_in	cell_type	0.70
epigenetic regulation	crosstalk_with	pathway	0.70
oligodendrocytes	active_in	cell_type	0.70
Wnt signaling	crosstalk_with	pathway	0.60
amyloid aggregation	mediates	process	0.60
pyroptosis	mediates	process	0.60
pericytes	active_in	cell_type	0.60
temporal lobe	active_in	brain_region	0.60
pyroptosis	crosstalk_with	pathway	0.60
oxidative stress response	crosstalk_with	pathway	0.60
mitochondrial dynamics	crosstalk_with	pathway	0.60
striatum	active_in	brain_region	0.60
substantia nigra	active_in	brain_region	0.60
astrocytes	active_in	cell_type	0.60
apoptosis pathway	crosstalk_with	pathway	0.60

Incoming (365)

Source	Relation	Type	Str
AMPK	participates_in	gene	0.90
stroke	involves	disease	0.90
RNA	participates_in	gene	0.90
neuroinflammation	involves	disease	0.90
Syn3	activates	drug	0.90
MAPK signaling	crosstalk_with	pathway	0.90
ERK	participates_in	gene	0.90
PI3K	participates_in	gene	0.90
PIK3CA	participates_in	gene	0.90
AKT	participates_in	gene	0.90
MTOR	participates_in	gene	0.90
P2RY12 activation	activates	process	0.90
PTEN	participates_in	gene	0.90
NF-kB signaling	crosstalk_with	pathway	0.90
MAPK	participates_in	gene	0.90
glioblastoma	involves	disease	0.90
ROS	participates_in	gene	0.90
diabetes	involves	disease	0.90
microglia	active_in	cell_type	0.85
HIF	participates_in	gene	0.80
epilepsy	involves	disease	0.80
Alzheimer's disease	involves	disease	0.80
MTOR	activates	gene	0.80
EGFR	participates_in	gene	0.80
JAK-STAT signaling	crosstalk_with	pathway	0.80
DNA	participates_in	gene	0.80
RAS	participates_in	gene	0.80
SLC7A11	participates_in	gene	0.80
JNK	participates_in	gene	0.80
JAK	participates_in	gene	0.80
GBM	participates_in	gene	0.80
GPX4	participates_in	gene	0.80
TNF	participates_in	gene	0.80
traumatic brain injury	involves	disease	0.80
SCD1	participates_in	gene	0.70
DMSO	participates_in	gene	0.70
PKA	participates_in	gene	0.70
TLR	participates_in	gene	0.70
BDNF-TrkB signaling	crosstalk_with	pathway	0.70
quercetin	modulates	compound	0.70
SREBP1	participates_in	gene	0.70
CASP3	participates_in	gene	0.70
SRPK1	participates_in	gene	0.70
MAPK1	participates_in	gene	0.70
Parkinson's disease	involves	disease	0.70
MEK	participates_in	gene	0.70
IRGM1	participates_in	gene	0.70
MAPK3	participates_in	gene	0.70
depression	involves	disease	0.70
P2RY12	activates	gene	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How does P2RY12-mediated VSMC dysfunction contribute to cerebrovascular neurodeg

neurodegeneration | 2026-04-07 | 7 hypotheses Top: 0.605

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

While the study establishes P2RY12's role in VSMC foam cell formation in atheros

closed · Rounds: 4 · Score: 0.62 · 2026-04-21

Related Research

Hypotheses and analyses mentioning PI3K-AKT-mTOR signaling in their description or question text

No additional research found