pathway

PI3K-AKT-mTOR signaling

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PI3K-AKT-mTOR signaling: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

393Connections

0Hypotheses

0Analyses

29Outgoing

50Incoming

No summary available yet. View on Wiki →

🔀 Pathway Info

Name	PI3K-AKT-mTOR signaling
Key Genes/Proteins	AKT, PI3K, MTOR, PTEN, MAPK, RNA
Related Diseases	neuroinflammation
Related Pathways	autophagy pathway, unfolded protein response, ferroptosis, NF-kB signaling

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    PI3K_AKT_mTOR_signaling["PI3K-AKT-mTOR signaling"] -->|"involved in"| Clear_Cell_Renal_Cell_Carcinom["Clear-Cell Renal Cell Carcinoma"]
    style Clear_Cell_Renal_Cell_Carcinom fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    PI3K_AKT_mTOR_signaling["PI3K-AKT-mTOR signaling"] -->|"crosstalk with"| autophagy_pathway["autophagy pathway"]
    style autophagy_pathway fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    PI3K_AKT_mTOR_signaling["PI3K-AKT-mTOR signaling"] -->|"crosstalk with"| unfolded_protein_response["unfolded protein response"]
    style unfolded_protein_response fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    PI3K_AKT_mTOR_signaling["PI3K-AKT-mTOR signaling"] -->|"active in"| microglia["microglia"]
    style microglia fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    PI3K_AKT_mTOR_signaling["PI3K-AKT-mTOR signaling"] -->|"active in"| macrophages["macrophages"]
    style macrophages fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    PI3K_AKT_mTOR_signaling["PI3K-AKT-mTOR signaling"] -->|"crosstalk with"| ferroptosis["ferroptosis"]
    style ferroptosis fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    PI3K_AKT_mTOR_signaling["PI3K-AKT-mTOR signaling"] -->|"active in"| hippocampus["hippocampus"]
    style hippocampus fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Syn3["Syn3"] -->|"activates"| PI3K_AKT_mTOR_signaling["PI3K-AKT-mTOR signaling"]
    style Syn3 fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    AKT["AKT"] -->|"participates in"| PI3K_AKT_mTOR_signaling["PI3K-AKT-mTOR signaling"]
    style AKT fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    PI3K["PI3K"] -->|"participates in"| PI3K_AKT_mTOR_signaling["PI3K-AKT-mTOR signaling"]
    style PI3K fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    MTOR["MTOR"] -->|"participates in"| PI3K_AKT_mTOR_signaling["PI3K-AKT-mTOR signaling"]
    style MTOR fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    PTEN["PTEN"] -->|"participates in"| PI3K_AKT_mTOR_signaling["PI3K-AKT-mTOR signaling"]
    style PTEN fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style PI3K_AKT_mTOR_signaling fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (30)

Target	Relation	Type	Str
autophagy pathway	crosstalk_with	pathway	0.90
unfolded protein response	crosstalk_with	pathway	0.90
microglia	active_in	cell_type	0.90
macrophages	active_in	cell_type	0.90
ferroptosis	crosstalk_with	pathway	0.90
ferroptosis	mediates	process	0.90
neural stem cells	active_in	cell_type	0.90
hippocampus	active_in	brain_region	0.80
cortex	active_in	brain_region	0.80
neurons	active_in	cell_type	0.80
blood-brain barrier	active_in	brain_region	0.80
lipid metabolism	crosstalk_with	pathway	0.80
endothelial cells	active_in	cell_type	0.70
epigenetic regulation	crosstalk_with	pathway	0.70
TGF-beta signaling	crosstalk_with	pathway	0.70
insulin signaling	crosstalk_with	pathway	0.70
oligodendrocytes	active_in	cell_type	0.70
pericytes	active_in	cell_type	0.60
astrocytes	active_in	cell_type	0.60
apoptosis pathway	crosstalk_with	pathway	0.60
pyroptosis	crosstalk_with	pathway	0.60
oxidative stress response	crosstalk_with	pathway	0.60
mitochondrial dynamics	crosstalk_with	pathway	0.60
striatum	active_in	brain_region	0.60
substantia nigra	active_in	brain_region	0.60
amyloid aggregation	mediates	process	0.60
pyroptosis	mediates	process	0.60
temporal lobe	active_in	brain_region	0.60
Wnt signaling	crosstalk_with	pathway	0.60

Incoming (363)

Source	Relation	Type	Str
AKT	participates_in	gene	0.90
PI3K	participates_in	gene	0.90
MTOR	participates_in	gene	0.90
PTEN	participates_in	gene	0.90
MAPK	participates_in	gene	0.90
NF-kB signaling	crosstalk_with	pathway	0.90
RNA	participates_in	gene	0.90
neuroinflammation	involves	disease	0.90
AMPK	participates_in	gene	0.90
stroke	involves	disease	0.90
MAPK signaling	crosstalk_with	pathway	0.90
ERK	participates_in	gene	0.90
glioblastoma	involves	disease	0.90
diabetes	involves	disease	0.90
ROS	participates_in	gene	0.90
PIK3CA	participates_in	gene	0.90
microglia	active_in	cell_type	0.85
HIF	participates_in	gene	0.80
EGFR	participates_in	gene	0.80
GPX4	participates_in	gene	0.80
SLC7A11	participates_in	gene	0.80
DNA	participates_in	gene	0.80
RAS	participates_in	gene	0.80
GBM	participates_in	gene	0.80
JNK	participates_in	gene	0.80
JAK	participates_in	gene	0.80
JAK-STAT signaling	crosstalk_with	pathway	0.80
Alzheimer's disease	involves	disease	0.80
epilepsy	involves	disease	0.80
TNF	participates_in	gene	0.80
MTOR	activates	gene	0.80
traumatic brain injury	involves	disease	0.80
IL1B	participates_in	gene	0.70
MTORC1	participates_in	gene	0.70
CREB	participates_in	gene	0.70
neurodegeneration	involves	disease	0.70
AKT1	participates_in	gene	0.70
Parkinson's disease	involves	disease	0.70
MAPK1	participates_in	gene	0.70
depression	involves	disease	0.70
CASP3	participates_in	gene	0.70
SRPK1	participates_in	gene	0.70
STAT3	participates_in	gene	0.70
TLR4	participates_in	gene	0.70
TREM2	participates_in	gene	0.70
NLR	participates_in	gene	0.70
NRBF2	participates_in	gene	0.70
LC3	participates_in	gene	0.70
RHEB	participates_in	gene	0.70
ERN1	participates_in	gene	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PI3K-AKT-mTOR signaling

Understanding Entity Pages

Wiki Pages (20)

IGF-1 Signaling Pathway in Neurodegeneration

Remyelination in Neurodegeneration

FA2H Gene

YAP/TAZ Signaling Pathway in Neurodegeneration

SPI1 Gene - PU.1

GAB2 — GRB2 Associated Binding Protein 2

Insulin and IGF Signaling in 4R-Tauopathies

PRKCI

HDAC10 Gene

C2 (Complement Component 2)

PTEN Protein

AKT (Protein Kinase B) Neurons

AKT1 Protein (Protein Kinase B Alpha)

CREB-Independent Neuronal Survival Pathways in Neurodegeneration

ATG14 Protein

AKT1 Gene

mTOR Signaling in 4R-Tauopathies

REG3A — Regenerating Family Member 3 Alpha