gene

PDK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PDK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

180Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

Transdiagnostic Proteomic Changes in Neurodegeneration

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🧬 Gene Info

Gene Symbol	PDK1
Function	Recent advances in proteomics have revealed remarkable convergence in protein alterations across distinct neurodegenerative diseases
Pathways	Cell Cycle, Differentiation, Glycolysis, Mitosis, Pi3K/Akt
GeneCards	PDK1
Human Protein Atlas	PDK1
Protein	AD Change
IL-6	↑
TNF-α	↑
C3	↑
TREM2	↑ (variants)
APOE	ε4: ↑
Associated Diseases	Aging, Als, Carcinoma, Cirrhosis, Infection, Ms
Interactions	MTOR, EGFR, ERCC3, CEBPB, EGF, PI3K
KG Connections	180 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PDK1["PDK1"] -->|"regulates"| ADAM17["ADAM17"]
    PDK1["PDK1"] -->|"activates"| Cirrhosis["Cirrhosis"]
    PDK1["PDK1"] -->|"activates"| Carcinoma["Carcinoma"]
    PDK1["PDK1"] -->|"activates"| Ms["Ms"]
    PDK1["PDK1"] -->|"activates"| Als["Als"]
    PDK1["PDK1"] -.->|"inhibits"| Cardiovascular["Cardiovascular"]
    EGF["EGF"] -->|"activates"| PDK1["PDK1"]
    CYP3A4["CYP3A4"] -->|"activates"| PDK1["PDK1"]
    SOD2["SOD2"] -->|"associated"| PDK1["PDK1"]
    CAT["CAT"] -->|"associated"| PDK1["PDK1"]
    style PDK1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (108)

Target	Relation	Type	Str
AKT1	phosphorylates	gene	0.90
Pi3K/Akt Pathway	inhibits	pathway	0.85
Als	activates	disease	0.75
Als	therapeutic_target	disease	0.75
Cancer	therapeutic_target	disease	0.75
Tumor	therapeutic_target	disease	0.75
AKT	activates	gene	0.70
ADAM17	regulates	gene	0.70
AKT	regulates	gene	0.70
Glycolysis	activates	pathway	0.70
Differentiation	regulates	pathway	0.70
Pi3K/Akt	therapeutic_target	pathway	0.70
Cirrhosis	activates	disease	0.65
Carcinoma	activates	disease	0.65
Ms	activates	disease	0.65
Cardiovascular	inhibits	disease	0.65
Als	inhibits	disease	0.65
Tumor	inhibits	disease	0.65
Hypertension	inhibits	disease	0.65
Ms	associated_with	disease	0.65
Als	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Cirrhosis	associated_with	disease	0.65
Ischemia	inhibits	disease	0.65
Aging	inhibits	disease	0.65
Ms	therapeutic_target	disease	0.65
ALS	activates	disease	0.65
Infection	implicated_in	disease	0.65
Aging	implicated_in	disease	0.65
Tumor	regulates	disease	0.65
Breast Cancer	regulates	disease	0.65
Cancer	regulates	disease	0.65
Colorectal Cancer	activates	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Hepatocellular Carcinoma	therapeutic_target	disease	0.65
MTOR	activates	gene	0.60
EGFR	activates	gene	0.60
ERCC3	activates	gene	0.60
CEBPB	activates	gene	0.60
PDK4	associated_with	gene	0.60
SOD1	associated_with	gene	0.60
TNFR2	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
SLC16A1	associated_with	gene	0.60
EGF	activates	gene	0.60
PI3K	activates	gene	0.60
CYP3A4	activates	gene	0.60
CLOCK	inhibits	gene	0.60

Incoming (72)

Source	Relation	Type	Str
Theranekron	upregulates	drug	0.95
h-2a1a95c1	targets_gene	hypothesis	0.90
EGF	activates	gene	0.70
AKT	activates	gene	0.70
PI3K	activates	gene	0.70
PI3K	therapeutic_target	gene	0.70
EGFR	activates	gene	0.70
CANCER	therapeutic_target	gene	0.70
CYP3A4	activates	gene	0.60
SOD2	associated_with	gene	0.60
CAT	associated_with	gene	0.60
BAX	associated_with	gene	0.60
SPR	associated_with	gene	0.60
PPARGC1A	associated_with	gene	0.60
CASP3	associated_with	gene	0.60
CEBPB	activates	gene	0.60
MTOR	activates	gene	0.60
PTEN	activates	gene	0.60
ERCC3	activates	gene	0.60
PERK	implicated_in	gene	0.60
AKT	implicated_in	gene	0.60
PGK1	regulates	gene	0.60
GAPDH	regulates	gene	0.60
TKT	regulates	gene	0.60
FBP1	regulates	gene	0.60
TP53	regulates	gene	0.60
E2F1	activates	gene	0.60
ENO1	activates	gene	0.60
PDK3	activates	gene	0.60
HK2	activates	gene	0.60
RHOA	therapeutic_target	gene	0.60
PTEN	therapeutic_target	gene	0.60
GAIN	therapeutic_target	gene	0.60
PIK3CA	therapeutic_target	gene	0.60
PI3K	regulates	gene	0.60
CYCLIN B1	regulates	gene	0.60
CDK1	regulates	gene	0.60
MYC	activates	gene	0.60
BMAL1	activates	gene	0.60
CLOCK	inhibits	gene	0.60
PI3K	interacts_with	gene	0.60
AKT1	activates	gene	0.60
FOXO1	activates	gene	0.60
SIRT2	activates	gene	0.60
CHKA	activates	gene	0.60
AKT	regulates	gene	0.60
AGING	inhibits	gene	0.60
ERK	activates	gene	0.60
APOPTOSIS	therapeutic_target	gene	0.60
APOPTOSIS	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Which cell types show the most significant expression changes for neurodegenerat

neurodegeneration | 2026-04-03 | 7 hypotheses Top: 0.529

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PDK1

Understanding Entity Pages

Summary

Wiki Pages (21)

Transdiagnostic Proteomic Changes in Neurodegeneration

NTF4 Protein

GSK-3β in Neurodegeneration

Neurotrophin Signaling Pathways in Neurodegeneration

Insulin Signaling in Parkinson's Disease

IGF-1 Signaling Pathway in Neurodegeneration

CNTF Signaling Pathway in Neurodegeneration

RICTOR Protein

BDNF/Neurotrophin Signaling in Neurodegeneration

PDHX Gene

NT-4 Signaling Pathway in Neurodegeneration

Energy Metabolism in Neurodegeneration

pdp1

GSK3B (Glycogen Synthase Kinase 3 Beta)

AKT2 Gene

epas1-protein

Integrated Stress Response in Alzheimer's Disease

PRKCD — Protein Kinase C Delta

TYROBP/DAP12 Microglia Signaling Pathway in Alzheimer's Disease

PDPK1 Gene