Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CHRM1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | CHRM1 |
| Chromosome | 11q12.3 |
| Protein Type | Gene |
| Function | encodes a 460-amino acid protein. |
| Amino Acids | 460 aa |
| GeneCards | CHRM1 |
| Human Protein Atlas | CHRM1 |
| Associated Diseases | neurodegeneration |
| Interactions | BDNF, CHAT |
| SciDEX Hypotheses | M1 Muscarinic Receptor Agonism as Pharmacological |
| KG Connections | 16 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
CHRM1["CHRM1"]
Schizophrenia["Schizophrenia"]
POLE["POLE"]
Actin(["Actin"])
neurodegeneration["neurodegeneration"]
CHRM1 -->|"regulates"| Schizophrenia
CHRM1 -->|"regulates"| POLE
CHRM1 -->|"regulates"| Actin
CHRM1 -->|"implicated in"| neurodegeneration
style CHRM1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
style Schizophrenia fill:#3e1a1a,stroke:#ef5350,stroke-width:2px,color:#fff
style POLE fill:#1a237e,stroke:#ce93d8,stroke-width:2px,color:#fff
style Actin fill:#1a237e,stroke:#4fc3f7,stroke-width:2px,color:#fff
style neurodegeneration fill:#1a1a2e,stroke:#888,stroke-width:2px,color:#fff| Target | Relation | Type | Str |
|---|---|---|---|
| stellate neuron excitation | activates | mechanism | 0.70 |
| cholinergic signaling | regulates | process | 0.70 |
| Schizophrenia | regulates | disease | 0.65 |
| Actin | regulates | protein | 0.60 |
| synaptic plasticity | participates_in | pathway | 0.60 |
| astrocytes | expressed_in | cell_type | 0.60 |
| neurons | expressed_in | cell_type | 0.60 |
| microglia | expressed_in | cell_type | 0.60 |
| POLE | regulates | gene | 0.60 |
| neuroinflammation | activates | disease | 0.60 |
| neurodegeneration | promoted: M1 Muscarinic Receptor Agonism as Pharmacological Exercise Substitute | disease | 0.59 |
| Source | Relation | Type | Str |
|---|---|---|---|
| H6 | muscarinic_cross_talk_target | hypothesis | 0.00 |
| hyp-SDA-2026-04-12-20260411-082446-2c1c9e2d-3 | targets_gene | hypothesis | 0.90 |
| BDNF | inhibits | gene | 0.60 |
| BDNF | activates | gene | 0.60 |
| CHAT | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| M1 Muscarinic Receptor Agonism as Pharmacological Exercise S | 0.589 | neurodegeneration | What are the specific circulating factor |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-26 | 7 hypotheses Top: 0.735
neurodegeneration | 2026-04-14 | 2 hypotheses Top: 0.589
neurodegeneration | 2026-04-12 | 3 hypotheses Top: 0.887
neurodegeneration | 2026-04-10 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 1.00 · 2026-04-26
closed · Rounds: 4 · Score: 0.30 · 2026-04-21
closed · Rounds: 4 · Score: 0.95 · 2026-04-15
closed · Rounds: 4 · Score: 0.79 · 2026-04-12
Hypotheses and analyses mentioning CHRM1 in their description or question text
No additional research found