gene

CHAT

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHAT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

339Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

CHAT is a gene implicated in neurodegeneration research. Key relationships include: associated with, protects against, regulates. Associated with ALZHEIMER'S, ALZHEIMER'S DISEASE, Als. Connected to 127 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CHAT
Chromosome	10q11.23
Function	The reaction mechanism involves
Molecular Weight	70 kDa
Amino Acids	748 aa
Exons	14
Pathways	Apoptosis, Cell Cycle
GeneCards	CHAT
Human Protein Atlas	CHAT
Taxonomy	ID
Cell Ontology (CL)	CL:0000100
Database	ID
Cell Ontology	CL:0002614
Cell Type	Preganglionic parasympathetic neurons
Location	Medulla oblongata, dorsal vagal complex
Associated Diseases	Als, Alzheimer, Alzheimer'S Disease, Anxiety, Dementia
Interactions	Rab5a, BDNF, TRKB, NGF, SYP, SLC22A1
SciDEX Hypotheses	Sensory-Motor Circuit Cross-Modal Compensation
KG Connections	339 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CHAT["CHAT"]
    CHAT -->|"interacts"| Rab5a["Rab5a"]
    CHAT -->|"co_expressed_with"| CHRNA7["CHRNA7"]
    CHAT -->|"regulates"| NGF["NGF"]
    CHAT -->|"target for"| Dementia["Dementia"]
    CHAT -.protects against.-> Inflammation["Inflammation"]
    CHAT -.protects against.-> Diabetes["Diabetes"]
    CHAT -.protects against.-> Neurodegeneration["Neurodegeneration"]
    CHAT -.protects against.-> Neuroinflammation["Neuroinflammation"]
    PER["PER"] -->|"interacts"| CHAT

Outgoing (231)

Target	Relation	Type	Str
Rab5a	interacts_with	protein	0.80
CHRNA7	co_expressed_with	gene	0.80
Alzheimer	associated_with	disease	0.75
Dementia	associated_with	disease	0.75
NGF	regulates	protein	0.70
CHRNA7	regulates	gene	0.70
ACETYLCHOLINE	activates	phenotype	0.65
Dementia	therapeutic_target	disease	0.65
Depression	associated_with	disease	0.65
Anxiety	associated_with	disease	0.65
Als	associated_with	disease	0.65
Ms	associated_with	disease	0.65
NEURON	associated_with	gene	0.65
Inflammation	protects_against	disease	0.65
Diabetes	protects_against	disease	0.65
Neurodegeneration	protects_against	disease	0.65
Neuroinflammation	protects_against	disease	0.65
Dementia	interacts_with	disease	0.65
Neuroblastoma	causes	disease	0.65
Alzheimer	causes	disease	0.65
Als	regulates	disease	0.65
Heart Failure	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Stroke	biomarker_for	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Als	expressed_in	disease	0.65
Alzheimer	activates	disease	0.65
Als	activates	disease	0.65
Vascular Dementia	transports	disease	0.65
Alzheimer	transports	disease	0.65
Dementia	transports	disease	0.65
ALS	transports	disease	0.65
Frontotemporal Dementia	transports	disease	0.65
ALS	expressed_in	disease	0.65
Frontotemporal Dementia	therapeutic_target	disease	0.65
Vascular Dementia	therapeutic_target	disease	0.65
CYP2D6	associated_with	gene	0.60
APOE	associated_with	gene	0.60
HMGCR	associated_with	gene	0.60
OPRM1	associated_with	gene	0.60
SLC30A8	associated_with	gene	0.60
COMT	associated_with	gene	0.60
NBEA	associated_with	gene	0.60
HTR2C	associated_with	gene	0.60
ADRA2A	associated_with	gene	0.60
BCHE	associated_with	gene	0.60
SLC6A2	associated_with	gene	0.60
SLC6A3	associated_with	gene	0.60
ABCB1	associated_with	gene	0.60

Incoming (108)

Source	Relation	Type	Str
Pterostilbene	upregulates	compound	0.90
h-7110565d	targets_gene	hypothesis	0.90
ALZHEIMER	associated_with	gene	0.70
ACHE	associated_with	gene	0.70
NEURONS	regulates	cell_type	0.65
MAOB	associated_with	gene	0.60
GABRA1	associated_with	gene	0.60
BCHE	associated_with	gene	0.60
ADRA2A	associated_with	gene	0.60
ADRB2	associated_with	gene	0.60
GSTP1	associated_with	gene	0.60
ABCB1	associated_with	gene	0.60
COMT	associated_with	gene	0.60
ATXN2	associated_with	gene	0.60
CACNA1A	associated_with	gene	0.60
APOE	co_discussed	gene	0.60
SLC30A8	associated_with	gene	0.60
SLC6A3	associated_with	gene	0.60
APOE	associated_with	gene	0.60
NBEA	associated_with	gene	0.60
HTR2C	associated_with	gene	0.60
HMGCR	associated_with	gene	0.60
TAU	causes	gene	0.60
BDNF	causes	gene	0.60
BDNF	regulates	gene	0.60
SIRT1	regulates	gene	0.60
TRKB	regulates	gene	0.60
ABCG2	associated_with	entity	0.60
SLC6A4	associated_with	gene	0.60
OPRM1	associated_with	gene	0.60
NGF	activates	gene	0.60
BDNF	activates	gene	0.60
SYP	activates	gene	0.60
NESTIN	activates	gene	0.60
EGF	activates	gene	0.60
TUBULIN	activates	gene	0.60
SOX10	activates	gene	0.60
GDNF	activates	gene	0.60
FGF2	activates	gene	0.60
SOX2	activates	gene	0.60
PPAR	transports	gene	0.60
APOE	transports	gene	0.60
ABCB1	transports	gene	0.60
NRF2	activates	gene	0.60
APOE	therapeutic_target	gene	0.60
CHRNA7	therapeutic_target	gene	0.60
PPAR	therapeutic_target	gene	0.60
ABCB1	therapeutic_target	gene	0.60
NLRP3	protects_against	gene	0.60
ABCB1	regulates	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Sensory-Motor Circuit Cross-Modal Compensation	0.312	neuroscience	Circuit-level neural dynamics in neurode

Mentioning Analyses (1)

Scientific analyses that reference this entity

Circuit-level neural dynamics in neurodegeneration

neuroscience | 2026-04-03 | 49 hypotheses Top: 0.709

Related Papers (10)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Molecular brake on firing pattern transitions in MHbChAT neurons to mediate nico [PMID:41903536]	Zheng ZW, Min PX, Luo YL, Mao XF, Zhang	Neuron	2026
Gut-brain cholinergic signaling mediates the antiseizure effects of Bacteroides [PMID:41547348]	Jia Y, Chen H, Zou Q, Chen S, Li J et al	Neuron	2026
Carnitine acetyltransferase acts as a unidirectional compensatory enzyme for cho [PMID:41629006]	Zhang Z, Wang J, He T, Hu T, Wu X et al.	Pestic Biochem Physiol	2026
Nanogel Delivery of Plumbagin from Nepenthes Khasiana Attenuates Neuroinflammati [PMID:41653259]	Zhang X, Zhang X	Appl Biochem Biotechnol	2026
Targeting cholinergic cells in a mouse model of Alzheimer's disease: Validating [PMID:41679590]	Farkas S, Jasper V, Nyers-Marosi K, Petr	Exp Neurol	2026
Lymphocyte-derived cholinergic circuits modulate germinal center output and B ce [PMID:41735533]	Nechanitzky D, Smith LK, Nechanitzky R,	Nat Immunol	2026
Selective genetic targeting of the mouse efferent vestibular nucleus identifies [PMID:41770522]	Mathews MA, Tung VWK, Reader-Harris EC,	J Neurophysiol	2026
Electroacupuncture Attenuates Colitis in Mice Through Activation of Vagus Cholin [PMID:41847427]	Qu Z, Luo M, Liu X, Su Y, Jing X	J Inflamm Res	2026
Hippocampal BiP Overexpression Rescues Cognitive Performance and Increases REM t [PMID:41928945]	Duncan WE, Fenik P, Strus E, Veasey S, N	bioRxiv	2026
A compound pulsed magnetic field achieves superior cognitive benefits against Al [PMID:41856031]	Wang X, Wang X, Zhao H, Zhao C, Wang P,	Neurotherapeutics : the journa	2026

CHAT

Understanding Entity Pages

Summary

Wiki Pages (21)

Dorsal Motor Nucleus of the Vagus

cbs-psp-daily-action-plan

Neurons — Cell Type Hierarchy

rankings

Pedunculopontine Nucleus Cholinergic Neurons in Neurodegeneration

Metabolomic Alterations in PSP

Rotigotine and Rivastigmine Combination Therapy for Alzheimer's Disease (NCT06702124)

Neurotransmitter System Changes in 4R-Tauopathies: Cross-Disease Comparison

vip-vasoactive-intestinal-peptide-signaling-neurodegeneration

Lateropontine Nucleus Neurons

slc22a1

Pedunculopontine Nucleus in Parkinson's Disease

Edinger-Westphal Nucleus Cholinergic Neurons

Striatal Cholinergic Interneurons

donepezil

Nucleus Accumbens Core Neurons

DLB Cognitive Fluctuation Mechanism Experiment

Brainstem Laterodorsal Tegmental Nucleus

Striatal Cholinergic Interneurons in Huntington's Disease

GABAergic Neurons — Cell Type Hierarchy