gene

CHAT

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHAT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

390Connections

2Hypotheses

3Analyses

50Outgoing

50Incoming

1Experiments

20Debates

Summary

CHAT is a gene implicated in neurodegeneration research. Key relationships include: associated with, protects against, regulates. Associated with ALZHEIMER'S, ALZHEIMER'S DISEASE, Als. Connected to 127 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	CHAT
Chromosome	10q11.23
Function	The reaction mechanism involves
Subcellular Localization	the cytoplasm of presynaptic nerve terminals, but also associates with synaptic vesicles for regulated neurotransmitter
Molecular Weight	70 kDa
Amino Acids	748 aa
Exons	14
Pathways	Apoptosis, Cell Cycle
GeneCards	CHAT
Human Protein Atlas	CHAT
Associated Diseases	Als, Alzheimer, Alzheimer's disease, Anxiety, Dementia
Interactions	ABCB1, ACHE, AD, AKT, ALZHEIMER, ALZHEIMER'S DISEASE
SciDEX Hypotheses	Sensory-Motor Circuit Cross-Modal Compensation Vagal Nerve Stimulation Combined with Probiotic Th
KG Connections	390 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CHAT["CHAT"]
    CHAT -->|"interacts"| Rab5a["Rab5a"]
    CHAT -->|"co_expressed_with"| CHRNA7["CHRNA7"]
    CHAT -->|"regulates"| NGF["NGF"]
    CHAT -->|"target for"| Dementia["Dementia"]
    CHAT -.protects against.-> Inflammation["Inflammation"]
    CHAT -.protects against.-> Diabetes["Diabetes"]
    CHAT -.protects against.-> Neurodegeneration["Neurodegeneration"]
    CHAT -.protects against.-> Neuroinflammation["Neuroinflammation"]
    PER["PER"] -->|"interacts"| CHAT

Outgoing (266)

Target	Relation	Type	Str
acetylcholine_synthesis	regulates	process	0.90
CHRNA7	interacts_with	gene	0.80
Rab5a	interacts_with	protein	0.80
Alzheimer	associated_with	disease	0.75
Dementia	associated_with	disease	0.75
NEURONS	causes	cell_type	0.70
GRIA1	activates	gene	0.70
PSD95	activates	gene	0.70
LDLR	mediates	gene	0.70
CHOLINERGIC	activates	cell_type	0.70
NEURONS	expresses	cell_type	0.70
NEURONS	markers	cell_type	0.70
NGF	regulates	protein	0.70
CHRNA7	regulates	gene	0.70
acetylcholine_synthesis	activates	biological_process	0.70
parasympathetic_tone	regulates	phenotype	0.70
Als	regulates	disease	0.65
Als	expressed_in	disease	0.65
NEURON	associated_with	gene	0.65
Alzheimer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Inflammation	protects_against	disease	0.65
Alzheimer	activates	disease	0.65
Diabetes	protects_against	disease	0.65
Neurodegeneration	protects_against	disease	0.65
Neuroinflammation	protects_against	disease	0.65
ALS	expressed_in	disease	0.65
Dementia	interacts_with	disease	0.65
Als	activates	disease	0.65
Als	associated_with	disease	0.65
Als	biomarker_for	disease	0.65
Stroke	biomarker_for	disease	0.65
Neuroblastoma	causes	disease	0.65
Depression	associated_with	disease	0.65
Alzheimer	causes	disease	0.65
Anxiety	associated_with	disease	0.65
Heart Failure	biomarker_for	disease	0.65
Frontotemporal Dementia	therapeutic_target	disease	0.65
Dementia	therapeutic_target	disease	0.65
ACETYLCHOLINE	activates	phenotype	0.65
Vascular Dementia	therapeutic_target	disease	0.65
Alzheimer	transports	disease	0.65
Dementia	transports	disease	0.65
ALS	transports	disease	0.65
Ms	associated_with	disease	0.65
Frontotemporal Dementia	transports	disease	0.65
Vascular Dementia	transports	disease	0.65
NEURONS	interacts_with	cell_type	0.60
TAU	interacts_with	gene	0.60
CACNA1A	associated_with	gene	0.60

Incoming (124)

Source	Relation	Type	Str
Pterostilbene	upregulates	compound	0.90
h-7110565d	targets	hypothesis	0.90
BDNF	protects_against	gene	0.70
ALZHEIMER	associated_with	gene	0.70
ACHE	associated_with	gene	0.70
NEURONS	regulates	cell_type	0.65
ABCB1	therapeutic_target	gene	0.60
APOE	therapeutic_target	gene	0.60
CHRNA7	therapeutic_target	gene	0.60
PPAR	therapeutic_target	gene	0.60
DEPRESSION	associated_with	gene	0.60
PER	interacts_with	gene	0.60
CYP2E1	associated_with	gene	0.60
ANXIETY	associated_with	gene	0.60
NEUROTOXICITY	causes	gene	0.60
ALZHEIMER	causes	gene	0.60
AMYLOID	causes	gene	0.60
AΒ	activates	gene	0.60
BDNF	activates	gene	0.60
SYP	activates	gene	0.60
AKT	activates	gene	0.60
AD	activates	gene	0.60
NGF	activates	gene	0.60
ALZHEIMER'S DISEASE	causes	gene	0.60
ACETYL-COA	associated_with	gene	0.60
AMYLOID	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
APOE	activates	gene	0.60
APP	activates	gene	0.60
BACE2	activates	gene	0.60
CD38	activates	gene	0.60
ASTROCYTE	activates	cell_type	0.60
ADRA2A	associated_with	gene	0.60
ADRB2	associated_with	gene	0.60
GSTP1	associated_with	gene	0.60
ATXN2	associated_with	gene	0.60
CACNA1A	associated_with	gene	0.60
NESTIN	activates	gene	0.60
EGF	activates	gene	0.60
BCHE	associated_with	gene	0.60
SOX10	activates	gene	0.60
GDNF	activates	gene	0.60
FGF2	activates	gene	0.60
SOX2	activates	gene	0.60
BDNF	associated_with	gene	0.60
TUBULIN	activates	gene	0.60
ASTROCYTES	activates	cell_type	0.60
AΒ	expresses	gene	0.60
CGAS	regulates	gene	0.60
B CELL	activates	cell_type	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Sensory-Motor Circuit Cross-Modal Compensation	0.546	neuroscience	Circuit-level neural dynamics in neurode
Vagal Nerve Stimulation Combined with Probiotic Therapy	0.000	-	What are the mechanisms by which gut mic

Mentioning Analyses (3)

Scientific analyses that reference this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Electroacupuncture ST37 treatment for DSS-induced colitis in mice	validation	colitis	0.950	0.00	mice	proposed	N/A

Related Papers (10)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Molecular brake on firing pattern transitions in MHbChAT neurons to mediate nico [PMID:41903536]	Zheng ZW, Min PX, Luo YL, Mao XF, Zhang	Neuron	2026
Gut-brain cholinergic signaling mediates the antiseizure effects of Bacteroides [PMID:41547348]	Jia Y, Chen H, Zou Q, Chen S, Li J et al	Neuron	2026
Carnitine acetyltransferase acts as a unidirectional compensatory enzyme for cho [PMID:41629006]	Zhang Z, Wang J, He T, Hu T, Wu X et al.	Pestic Biochem Physiol	2026
Nanogel Delivery of Plumbagin from Nepenthes Khasiana Attenuates Neuroinflammati [PMID:41653259]	Zhang X, Zhang X	Appl Biochem Biotechnol	2026
Targeting cholinergic cells in a mouse model of Alzheimer's disease: Validating [PMID:41679590]	Farkas S, Jasper V, Nyers-Marosi K, Petr	Exp Neurol	2026
Lymphocyte-derived cholinergic circuits modulate germinal center output and B ce [PMID:41735533]	Nechanitzky D, Smith LK, Nechanitzky R,	Nat Immunol	2026
Selective genetic targeting of the mouse efferent vestibular nucleus identifies [PMID:41770522]	Mathews MA, Tung VWK, Reader-Harris EC,	J Neurophysiol	2026
Electroacupuncture Attenuates Colitis in Mice Through Activation of Vagus Cholin [PMID:41847427]	Qu Z, Luo M, Liu X, Su Y, Jing X	J Inflamm Res	2026
Hippocampal BiP Overexpression Rescues Cognitive Performance and Increases REM t [PMID:41928945]	Duncan WE, Fenik P, Strus E, Veasey S, N	bioRxiv	2026
A compound pulsed magnetic field achieves superior cognitive benefits against Al [PMID:41856031]	Wang X, Wang X, Zhao H, Zhao C, Wang P,	Neurotherapeutics : the journa	2026

Debates (20)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning CHAT in their description or question text

No additional research found

CHAT

Understanding Entity Pages

Summary

Wiki Pages (4)

CHAT Gene

Cholinergic Efferent (CHAT) Neurons

CHAT Protein

CHAT Protein

Pathway Diagram

Outgoing (266)

Incoming (124)

Targeting Hypotheses (2)

Mentioning Analyses (3)

Circuit-level neural dynamics in neurodegeneration

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

Lipid raft composition changes in synaptic neurodegeneration

Experiments (1)

Related Papers (10)

Debates (20)

Extended debate: CYP46A1 Overexpression Gene Therapy

Extended debate: Closed-loop transcranial focused ultrasound with 40Hz gamma ent

Extended debate: Closed-loop tACS targeting EC-II SST interneurons to block tau

Debate: Closed-loop transcranial focused ultrasound targeting entorhinal PV inte

Debate: Closed-loop tACS targeting EC-II SST interneurons to block tau propagati

Debate: Closed-loop transcranial focused ultrasound to restore hippocampal gamma

Debate: Closed-loop tACS targeting EC-II PV interneurons to suppress burst firin

Debate: Closed-loop tACS targeting EC-II somatostatin interneurons to restore de

Debate: Closed-loop transcranial focused ultrasound with real-time gamma feedbac

Hypothesis debate: Closed-loop transcranial alternating current stimulation to r

Related Research