gene

POLE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about POLE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

242Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Comprehensive page on POLE DNA polymerase epsilon, its role in DNA replication/repair, and connections to neurodegenerative diseases including Alzheimer's and Parkinson's

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🧬 Gene Info

Gene Symbol	POLE
Full Name	DNA Polymerase Epsilon
Chromosome	12q24.3
Function	is a gene located on chromosome 12q24.
Primary Expression	Hippocampus, Cerebral cortex, Cerebellum, Substantia nigra
Molecular Weight	261 kDa
Amino Acids	2308 aa
Pathways	Apoptosis, Blood-Brain Barrier, Er Stress, Ferroptosis, Inflammasome
UniProt ID	Q07864
NCBI Gene ID	5426
Ensembl ID	ENSG00000177042
OMIM	174762
GeneCards	POLE
Human Protein Atlas	POLE
Protein Class	DNA polymerase, B family
Associated Diseases	Aging, Anxiety, Cancer, Depression, Epilepsy, Neurodegeneration
Interactions	TREM2, NLRP3, TLR4, GSDMD, MYD88, P38
KG Connections	242 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: POLE — AlphaFold Q07864 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    POLE["POLE"] -->|"associated with"| Aging["Aging"]
    POLE["POLE"] -->|"associated with"| Traumatic_Brain_Injury["Traumatic Brain Injury"]
    POLE["POLE"] -->|"associated with"| Depression["Depression"]
    POLE["POLE"] -->|"associated with"| Anxiety["Anxiety"]
    POLE["POLE"] -->|"activates"| Als["Als"]
    POLE["POLE"] -->|"activates"| Neuroinflammation["Neuroinflammation"]
    POLE["POLE"] -->|"activates"| Parkinson["Parkinson"]
    POLE["POLE"] -->|"activates"| Inflammation["Inflammation"]
    POLE["POLE"] -.->|"inhibits"| Ms["Ms"]
    POLE["POLE"] -->|"activates"| Tumor["Tumor"]
    POLE["POLE"] -->|"activates"| Ms["Ms"]
    POLE["POLE"] -->|"therapeutic target"| Carcinoma["Carcinoma"]
    style POLE fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Aging fill:#ef5350,stroke:#333,color:#e0e0e0
    style Traumatic_Brain_Injury fill:#ef5350,stroke:#333,color:#e0e0e0
    style Depression fill:#ef5350,stroke:#333,color:#e0e0e0
    style Anxiety fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Neuroinflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style Parkinson fill:#ef5350,stroke:#333,color:#e0e0e0
    style Inflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style Tumor fill:#ef5350,stroke:#333,color:#e0e0e0
    style Carcinoma fill:#ef5350,stroke:#333,color:#e0e0e0

Outgoing (154)

Target	Relation	Type	Str
Als	treats	disease	0.85
Mismatch Repair	associated_with	pathway	0.80
Als	activates	disease	0.75
Parkinson	activates	disease	0.75
Inflammation	therapeutic_target	disease	0.75
Tumor	treats	disease	0.75
Cancer	treats	disease	0.75
Carcinoma	treats	disease	0.75
CANCER	treats	gene	0.70
Aging	associated_with	disease	0.65
Traumatic Brain Injury	associated_with	disease	0.65
Depression	associated_with	disease	0.65
Anxiety	associated_with	disease	0.65
Neuroinflammation	activates	disease	0.65
Inflammation	activates	disease	0.65
Ms	inhibits	disease	0.65
Tumor	activates	disease	0.65
Ms	activates	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Cirrhosis	therapeutic_target	disease	0.65
Hepatitis	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
ALS	activates	disease	0.65
Cancer	associated_with	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Neurodegeneration	activates	disease	0.65
Cancer	expressed_in	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	associated_with	disease	0.65
Epilepsy	therapeutic_target	disease	0.65
Bipolar	regulates	disease	0.65
Epilepsy	causes	disease	0.65
Epilepsy	encodes	disease	0.65
Schizophrenia	interacts_with	disease	0.65
Ischemia	inhibits	disease	0.65
Als	inhibits	disease	0.65
Aging	protects_against	disease	0.65
Parkinson	protects_against	disease	0.65
Neuroinflammation	protects_against	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Inflammation	protects_against	disease	0.65
Neurodegeneration	protects_against	disease	0.65
Autoimmune	protects_against	disease	0.65
TREM2	activates	gene	0.60
NLRP3	activates	gene	0.60
TLR4	activates	gene	0.60
GSDMD	activates	gene	0.60

Incoming (88)

Source	Relation	Type	Str
INFLAMMATION	therapeutic_target	gene	0.70
PARKINSON'S DISEASE	activates	gene	0.70
PARKINSON	activates	gene	0.70
MYD88	activates	gene	0.60
NLRP3	activates	gene	0.60
TREM2	activates	gene	0.60
GSDMD	activates	gene	0.60
JUN	activates	gene	0.60
CD81	therapeutic_target	gene	0.60
CLDN1	therapeutic_target	gene	0.60
LDLR	therapeutic_target	gene	0.60
EGFR	therapeutic_target	gene	0.60
OCLN	therapeutic_target	gene	0.60
TCF3	therapeutic_target	gene	0.60
LATS2	therapeutic_target	gene	0.60
DISC1	therapeutic_target	gene	0.60
TLR2	therapeutic_target	gene	0.60
APC	therapeutic_target	gene	0.60
TLR4	activates	gene	0.60
P38	activates	gene	0.60
JNK	activates	gene	0.60
ARID1A	treats	gene	0.60
PI3K	treats	gene	0.60
GPX4	activates	gene	0.60
BCL2	activates	gene	0.60
SLC7A11	activates	gene	0.60
NCOA4	activates	gene	0.60
BAX	activates	gene	0.60
S100A9	activates	gene	0.60
IBA1	activates	gene	0.60
DNAJB6	regulates	gene	0.60
DYNACTIN	activates	gene	0.60
DYNEIN	interacts_with	gene	0.60
MECP2	therapeutic_target	gene	0.60
NGF	therapeutic_target	gene	0.60
DCTN1	activates	gene	0.60
NGF	causes	gene	0.60
NGF	encodes	gene	0.60
WNT7A	activates	gene	0.60
CHRM1	regulates	gene	0.60
LAMP1	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
AXIN	therapeutic_target	gene	0.60
ATP	activates	gene	0.60
NF-ΚB	activates	gene	0.60
DEPRESSION	associated_with	gene	0.60
ANXIETY	associated_with	gene	0.60
BRAIN INJURY	associated_with	gene	0.60
APOPTOSIS	activates	gene	0.60
IL-6	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

POLE

Understanding Entity Pages

Summary

Wiki Pages (21)

POLE — DNA Polymerase Epsilon

NPM1 Gene

Frontotemporal Dementia (FTD) Mechanistic Pathway

Traumatic Brain Injury and Neurodegeneration Pathway

Stargardt Disease

Braak Staging and Tau Propagation Pathway

mitochondrial-dynamics-dysfunction-parkinsons

Brain Network Connectivity in PSP

AD Biomarker-to-Mechanism Mapping

semantic-dementia

locus-coeruleus

Astrocyte Metabolic Enhancement Therapy for PD

Posterior Cortical Atrophy

ftd-tdp43-pathway

Tau Network Propagation Hypothesis (Prion-Like Spread)

FTD-ALS Spectrum

Diffusion MRI (DTI) in Neurodegeneration

LRRK2 Transgenic Mouse Model for Parkinson's Disease

Centrosome