protein

CLDN5PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CLDN5PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Claudin 5 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

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🔬 Protein Info

Gene Symbol	CLDN5PROTEIN
Full Name	Claudin-5 Protein
Protein Family	Claudin family
Target Class	Structural Protein
Function	is an important component in the neurobiology of neurodegenerative diseases.
Mechanism of Action	Tight junction protein modulation - no established druggable mechanisms
Druggability	Undruggable (0.20)
Clinical Stage	Approved
Molecular Weight	21.8 kDa
UniProt ID	O00511
GeneCards	CLDN5PROTEIN
Human Protein Atlas	CLDN5PROTEIN
Two extracellular loops	The first extracellular loop determines charge selectivity
Cytoplasmic N- and C-termini	The C-terminus interacts with PDZ domain proteins including ZO-1, ZO-2, and ZO-3
Associated Diseases	ALS, blood-brain barrier tight junction integrity, blood-retinal barrier integrity, Brain Edema, neurodegeneration, stroke
Known Drugs/Compounds	curcumin, resveratrol
Interactions	ABCB1, ABCD1, ABCD2, ABCG2, AMYLOID, AND
SciDEX Target	View Target Profile (5 clinical trials)
SciDEX Hypotheses	Gut-BBB Axis: Tributyrin/Butyrate HDAC Inhibition Plasma Claudin-5 Proteolytic Fragments Distinguish Vascular and Perivascular Cell Type Vulnerability: (+2 more)
KG Connections	396 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: CLDN5PROTEIN — AlphaFold O00511 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Claudin-5 Protein

protein · 674 words

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Pathway Diagram

graph TD
    CLDN5PROTEIN["CLDN5PROTEIN"]
    neurodegeneration["neurodegeneration"]
    CLDN5PROTEIN -->|"implicated_in"| neurodegeneration
    style CLDN5PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CLDN5PROTEIN in their description or question text

No additional research found