Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about VPS33A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | VPS33A |
| Full Name | VPS33A |
| Aliases | Vacuolar Protein Sorting 33 Homolog A |
| Chromosome | 12q24.31 |
| Protein Type | Gene |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 57.7 kDa |
| Amino Acids | 552 aa |
| NCBI Gene ID | Search NCBI |
| GeneCards | VPS33A |
| Human Protein Atlas | VPS33A |
| Associated Diseases | Als |
| Interactions | STX17, UVRAG, VPS16, LC3, AND, LYSOSOME |
| KG Connections | 20 knowledge graph edges |
| Databases | GeneCardsUniProtHPASTRING |
Knowledge base pages for this entity
graph TD
VPS33A["<b>VPS33A</b>"]
VPS16["VPS16"]
VPS33A -->|"binds"| VPS16
Als{"Als"}
VPS33A -->|"associated with"| Als
STX17["STX17"]
VPS33A -->|"inhibits"| STX17
UVRAG["UVRAG"]
VPS33A -->|"interacts with"| UVRAG
VPS33A -->|"inhibits"| VPS16
LC3["LC3"]
VPS33A -->|"inhibits"| LC3
neurodegeneration["neurodegeneration"]
VPS33A -->|"implicated in"| neurodegeneration
UVRAG -->|"interacts with"| VPS33A
STX17 -->|"inhibits"| VPS33A
style VPS33A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| VPS16 | binds | protein | 0.90 |
| Als | associated_with | disease | 0.65 |
| STX17 | inhibits | gene | 0.60 |
| UVRAG | interacts_with | gene | 0.60 |
| VPS16 | inhibits | gene | 0.60 |
| LC3 | inhibits | gene | 0.60 |
| VPS16 | associated_with | gene | 0.60 |
| COX15 | associated_with | gene | 0.60 |
| RPL4 | associated_with | gene | 0.60 |
| AND | inhibits | gene | 0.60 |
| LYSOSOME | interacts_with | gene | 0.60 |
| ATP | activates | gene | 0.60 |
| ACSL5 | associated_with | gene | 0.60 |
| Ras | activates | protein | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||