gene

CTSC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CTSC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

12Connections

0Hypotheses

0Analyses

6Outgoing

6Incoming

0Experiments

0Debates

Summary

CTSC is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with Cancer, Tumor. Connected to 13 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CTSC
Full Name	Cathepsin C
Chromosome	10q22.1
Protein Type	Protease
Function	is a lysosomal cysteine protease that plays crucial roles in protein degradation and activation of serine proteases.
Primary Expression	immune cells and has been implicated in various neurodegenerative diseases through its involvement in neuroinflammation and protein aggregation[@cardo
GeneCards	CTSC
Human Protein Atlas	CTSC
Protein degradation	Catalyzes the removal of dipeptides from the N-terminus of proteins
Protease activation	Activates serine proteases including cathepsin G, elastase, and chymase in hematopoietic cells
Immune function	Plays a role in neutrophil-mediated immune responses[@korkmaz2022]
Associated Diseases	Cancer, Tumor
KG Connections	12 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CTSC — Cathepsin C

gene · 589 words

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Pathway Diagram

graph TD
    CTSC["CTSC"]
    Tumor{"Tumor"}
    CTSC -->|"associated_with"| Tumor
    Cancer{"Cancer"}
    CTSC -->|"associated_with"| Cancer
    DNA["DNA"]
    CTSC -->|"associated_with"| DNA
    Mtor(["Mtor"])
    CTSC -->|"associated_with"| Mtor
    Drug_Resistance(["Drug Resistance"])
    CTSC -->|"associated_with"| Drug_Resistance
    Glycolysis(["Glycolysis"])
    CTSC -->|"associated_with"| Glycolysis
    HK2["HK2"]
    HK2 -->|"associated_with"| CTSC
    TP53["TP53"]
    TP53 -->|"associated_with"| CTSC
    MTORC1["MTORC1"]
    MTORC1 -->|"associated_with"| CTSC
    CANCER["CANCER"]
    CANCER -->|"associated_with"| CTSC
    GENES["GENES"]
    GENES -->|"associated_with"| CTSC
    PHGDH["PHGDH"]
    PHGDH -->|"associated_with"| CTSC
    neurodegeneration["neurodegeneration"]
    CTSC -->|"implicated_in"| neurodegeneration

Outgoing (6)

Target	Relation	Type	Str
Tumor	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Mtor	associated_with	pathway	0.60
Drug Resistance	associated_with	pathway	0.60
Glycolysis	associated_with	pathway	0.60
DNA	associated_with	gene	0.60

Incoming (6)

Source	Relation	Type	Str
HK2	associated_with	gene	0.60
TP53	associated_with	gene	0.60
MTORC1	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
GENES	associated_with	gene	0.60
PHGDH	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CTSC in their description or question text

No additional research found