Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Drug Resistance: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | Drug Resistance |
| Key Genes/Proteins | CANCER, OVERVIEW, AUTOPHAGY, APOPTOSIS, DNA, PI3K |
| Related Diseases | Tumor, Cancer, Als |
Knowledge base pages for this entity
graph TD
Drug_Resistance["<b>Drug Resistance</b>"]
CANCER(["CANCER"])
CANCER -->|"regulates"| Drug_Resistance
Tumor{"Tumor"}
Tumor -->|"regulates"| Drug_Resistance
Cancer{"Cancer"}
Cancer -->|"regulates"| Drug_Resistance
style Drug_Resistance fill:#1a3a4a,stroke:#81c784,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| CANCER | targets | disease | 0.65 |
| CANCER | produces | disease | 0.65 |
| STRESS GRANULES | associated_with | concept | 0.50 |
| Reactive Oxygen Species | associated_with | process | 0.50 |
| PD-L1 | inhibits | concept | 0.50 |
| PI3K/AKT/mTOR | activates | pathway | 0.50 |
| Myeloma | activates | disease | 0.50 |
| CENTRAL NERVOUS SYSTEM | inhibits | concept | 0.50 |
| CISPLATIN | associated_with | drug | 0.50 |
| OSIMERTINIB | associated_with | drug | 0.45 |
| GEMCITABINE | associated_with | drug | 0.45 |
| MTOR PATHWAY | associated_with | pathway | 0.45 |
| PI3K/AKT/MTOR | associated_with | pathway | 0.45 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CANCER | regulates | gene | 1.00 |
| Tumor | regulates | disease | 1.00 |
| Cancer | regulates | disease | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| Tumor | therapeutic_target | disease | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| Tumor | activates | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| OVERVIEW | therapeutic_target | gene | 1.00 |
| AUTOPHAGY | therapeutic_target | gene | 1.00 |
| APOPTOSIS | therapeutic_target | gene | 1.00 |
| DNA | therapeutic_target | gene | 1.00 |
| PI3K | therapeutic_target | gene | 1.00 |
| GENES | therapeutic_target | gene | 1.00 |
| AKT | therapeutic_target | gene | 1.00 |
| MTOR | therapeutic_target | gene | 1.00 |
| PI3K | activates | gene | 1.00 |
| EGFR | therapeutic_target | gene | 1.00 |
| AKT | activates | gene | 1.00 |
| Carcinoma | therapeutic_target | disease | 1.00 |
| Als | activates | disease | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| P53 | therapeutic_target | gene | 1.00 |
| BCL-2 | therapeutic_target | gene | 1.00 |
| MIRNAS | therapeutic_target | gene | 1.00 |
| Colorectal Cancer | therapeutic_target | disease | 1.00 |
| APOPTOSIS | activates | gene | 1.00 |
| CANCER | activates | gene | 1.00 |
| Cancer | activates | disease | 1.00 |
| Breast Cancer | therapeutic_target | disease | 1.00 |
| Aging | therapeutic_target | disease | 1.00 |
| Lung Cancer | therapeutic_target | disease | 1.00 |
| Leukemia | therapeutic_target | disease | 1.00 |
| Gastric Cancer | therapeutic_target | disease | 1.00 |
| AURKA | promotes | gene | 0.95 |
| Stress Granules | promotes | process | 0.95 |
| AURKA | associated_with | gene | 0.93 |
| Protein Arginine Methyltransferases | involved_in | enzyme | 0.92 |
| MTOR | promotes | protein | 0.90 |
| AKT | promotes | protein | 0.90 |
| STAT3 | promotes | protein | 0.90 |
| Autophagy | contributes_to | process | 0.90 |
| Survivin | promotes | protein | 0.90 |
| Pi3K/Akt/Mtor Pathway | mediates | pathway | 0.90 |
| PI3K/AKT/mTOR | contributes_to | pathway | 0.90 |
| Survivin | mediates | protein | 0.90 |
| OVERVIEW | regulates | gene | 0.90 |
| BCL2 | therapeutic_target | gene | 0.90 |
| ERK | therapeutic_target | gene | 0.90 |
| YB-3-17 | suppresses | compound | 0.88 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||