Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CONNEXIN43: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | CONNEXIN43 |
| Key Genes/Proteins | GJA1 |
| Related Diseases | Ischemic Brain Injury |
Knowledge base pages for this entity
graph TD
CONNEXIN43["CONNEXIN43"]
CONNEXIN43 -->|"expressed in"| Astrocytes["Astrocytes"]
CONNEXIN43 -->|"interacts"| Hemichannel["Hemichannel"]
CONNEXIN43 -->|"mediates"| Gap_Junctions["Gap Junctions"]
CONNEXIN43 -->|"mediates"| Ion_Homeostasis["Ion Homeostasis"]
CONNEXIN43 -->|"contributes to"| Ischemic_Brain_Injury["Ischemic Brain Injury"]
CONNEXIN43 -->|"interacts"| P2_RECEPTORS["P2 RECEPTORS"]
GJA1["GJA1"] -->|"encodes"| CONNEXIN43
Gap26["Gap26"] -->|"inhibits"| CONNEXIN43
P2_Receptors["P2 Receptors"] -->|"interacts"| CONNEXIN43| Target | Relation | Type | Str |
|---|---|---|---|
| Hemichannel | interacts_with | protein | 0.95 |
| Hemichannel | involved_in | process | 0.95 |
| Alzheimer's Disease | associated_with | disease | 0.95 |
| Astrocytes | expressed_in | cell_type | 0.95 |
| Alzheimer's disease | associated_with | disease | 0.95 |
| Astrocytes | expressed_in | cell_type | 0.95 |
| Gap Junctions | mediates | process | 0.90 |
| Ion Homeostasis | mediates | process | 0.90 |
| Ischemic Brain Injury | contributes_to | disease | 0.90 |
| Ischemic Brain Injury | associated_with | disease | 0.90 |
| P2 RECEPTORS | interacts_with | receptor | 0.90 |
| Metabolic Support | mediates | process | 0.85 |
| Glial Network Signalling | mediates | process | 0.85 |
| Hemichannels | involved_in | protein | 0.85 |
| Hemichannels | mediates | process | 0.85 |
| Microglia | expressed_in | cell_type | 0.85 |
| Apoptotic Cell Death | causes | process | 0.85 |
| Amyloidosis | contributes_to | disease | 0.80 |
| Apoptosis | causes | process | 0.80 |
| MICROGLIA | regulates | cell_type | 0.80 |
| cognitive deficits | prevents | process | 0.80 |
| functional recovery | improves | process | 0.80 |
| MICROGLIA | inhibits | cell_type | 0.80 |
| functional recovery | inhibits | process | 0.80 |
| ASTROCYTIC | expressed_in | cell_type | 0.80 |
| cognitive deficits | mitigates | process | 0.80 |
| functional_recovery | inhibition_improves | process | 0.80 |
| ALZHEIMER | therapeutic_target | disease | 0.80 |
| gap_junction_pathway | forms | pathway | 0.80 |
| Gap junctions | involved_in | pathway | 0.60 |
| CRF-R1 | interacts_with | protein | 0.60 |
| Calcium signaling | regulates | pathway | 0.60 |
| Alzheimer's disease | implicated_in | disease | 0.60 |
| Neuroinflammation | contributes_to | pathway | 0.60 |
| microglia reactivity | regulates | process | 0.60 |
| Alzheimer's disease | therapeutic_target | disease | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| GJA1 | encodes | gene | 0.95 |
| Gap26 | inhibits | compound | 0.85 |
| P2 Receptors | interacts_with | receptor | 0.80 |
| GJA1 | encodes | gene | 0.80 |
| GJA1 | interacts_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.791
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity