concept

CALCIUM SIGNALING

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CALCIUM SIGNALING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

615Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Calcium Signaling — Investment Landscape Analysis

investment · 810 words

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Pathway Diagram

graph TD
    CALCIUM_SIGNALING["CALCIUM SIGNALING"]
    CALCIUM_SIGNALING -->|"interacts"| Phagocytosis["Phagocytosis"]
    CALCIUM_SIGNALING -->|"interacts"| Apoptosis["Apoptosis"]
    CALCIUM_SIGNALING -->|"interacts"| Akt["Akt"]
    CALCIUM_SIGNALING -->|"interacts"| Pi3K["Pi3K"]
    CALCIUM_SIGNALING -->|"interacts"| Blood_Brain_Barrier["Blood-Brain Barrier"]
    BCL2["BCL2"] -->|"regulates"| CALCIUM_SIGNALING
    JUN["JUN"] -->|"regulates"| CALCIUM_SIGNALING
    MCOLN1["MCOLN1"] -->|"regulates"| CALCIUM_SIGNALING
    BANG["BANG"] -->|"activates"| CALCIUM_SIGNALING
    GPR37["GPR37"] -->|"activates"| CALCIUM_SIGNALING
    GENES["GENES"] -->|"regulates"| CALCIUM_SIGNALING
    Neurodegeneration["Neurodegeneration"] -->|"regulates"| CALCIUM_SIGNALING
    Als["Als"] -->|"regulates"| CALCIUM_SIGNALING
    Ms["Ms"] -->|"regulates"| CALCIUM_SIGNALING
    Inflammation["Inflammation"] -->|"activates"| CALCIUM_SIGNALING

Outgoing (117)

Target	Relation	Type	Str
ds-db4a006ea647	provides_data_for	dataset	1.00
Macrophage Phagocytosis	mediates	process	0.90
Neuroregeneration	regulates	process	0.90
Neuronal Cell Death	mediates	process	0.85
mitochondrial function	regulates	process	0.85
Neuronal Dendrites	involved_in	cell_type	0.80
neurons	active_in	cell_type	0.80
synaptic plasticity	crosstalk_with	pathway	0.70
astrocytes	active_in	cell_type	0.70
neural stem cells	active_in	cell_type	0.70
CDK5	regulates	gene	0.65
INFLAMMATION	causes	phenotype	0.65
NEURODEGENERATION	treats	phenotype	0.65
cortex	active_in	brain_region	0.60
unfolded protein response	crosstalk_with	pathway	0.60
hippocampus	active_in	brain_region	0.60
microglia	active_in	cell_type	0.60
blood-brain barrier	active_in	brain_region	0.60
pericytes	active_in	cell_type	0.60
oligodendrocytes	active_in	cell_type	0.60
Phagocytosis	interacts_with	pathway	0.55
Akt	interacts_with	pathway	0.55
Apoptosis	interacts_with	pathway	0.55
Pi3K	interacts_with	pathway	0.55
Blood-Brain Barrier	interacts_with	pathway	0.55
COMPLEMENT	co_discussed	entity	0.50
PHAGOCYTOSIS	co_discussed	entity	0.50
Microglia	activates	cell_type	0.50
Neutrophil	activates	cell_type	0.50
Macrophage	activates	cell_type	0.50
Astrocyte	regulates	cell_type	0.50
Neuron	regulates	cell_type	0.50
Astrocyte	expressed_in	cell_type	0.50
TNF	associated_with	gene	0.50
IL6	associated_with	gene	0.50
P2X7	associated_with	gene	0.50
NEURONS	associated_with	cell_type	0.50
P2RX7	co_discussed	entity	0.50
LONG-TERM POTENTIATION	co_discussed	entity	0.50
MICROGLIA	co_discussed	entity	0.50
AGING	associated_with	phenotype	0.50
CASP3	associated_with	gene	0.50
VEGFA	associated_with	gene	0.50
TP53	associated_with	gene	0.50
Oligodendrocyte	activates	cell_type	0.50
Cardiomyocyte	activates	cell_type	0.50
Neuron	activates	cell_type	0.50
STING	co_discussed	entity	0.50
Neuron	contributes_to	cell_type	0.50
Dopaminergic	contributes_to	cell_type	0.50

Incoming (498)

Source	Relation	Type	Str
ds-db4a006ea647	data_in	dataset	1.00
ER-Mitochondria Contact Sites	involved_in	mechanism	0.90
ER-mitochondria distance	modulates	mechanism	0.90
MERCS	regulates	process	0.90
Er-Plasma Membrane Junctions	mediates	mechanism	0.90
MAMs	mediates	process	0.90
GRIN1	mediates	gene	0.90
APOE	inhibits	gene	0.90
ANNEXINS	involved_in	protein	0.90
ER-Plasma Membrane Junctions	mediates	mechanism	0.85
PKC	participates_in	gene	0.85
P2 RECEPTORS	regulates	receptor	0.85
APOE	associated_with	gene	0.85
neuroinflammation	involves	disease	0.80
NEUROGRANIN	activates	protein	0.80
Alzheimer's disease	involves	disease	0.80
Voltage-Gated Calcium Channels	regulates	protein	0.80
Als	regulates	disease	0.80
APOPTOSIS	therapeutic_target	gene	0.80
Alzheimer	therapeutic_target	disease	0.80
neurons	active_in	cell_type	0.75
Rizzuto R	involved_in	protein	0.75
GLUCOCORTICOID RECEPTOR	regulates	receptor	0.75
AQP4	involved_in	protein	0.75
INFLAMMATION	regulates	gene	0.70
synaptic plasticity	mediates	pathway	0.70
AUTOPHAGY	activates	gene	0.70
MITOPHAGY	regulates	gene	0.70
BCL2	regulates	protein	0.70
NEURODEGENERATION	regulates	gene	0.70
Neurodegeneration	regulates	disease	0.70
Huntington's disease	involves	disease	0.70
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.70
ALZHEIMER	therapeutic_target	gene	0.70
Als	therapeutic_target	disease	0.70
CASP3	regulates	gene	0.65
CREB	participates_in	gene	0.65
VEGFA	regulates	gene	0.65
Inflammation	regulates	disease	0.65
NEURONS	regulates	cell_type	0.65
OXIDATIVE STRESS	regulates	phenotype	0.65
LIPID PEROXIDATION	protects_against	phenotype	0.65
AKT1	participates_in	gene	0.60
GPR37	activates	gene	0.60
AND	associated_with	gene	0.60
TRPML1	associated_with	gene	0.60
ADAM10	activates	gene	0.60
TRPML2	regulates	gene	0.60
CAV1	contributes_to	gene	0.60
PLCB4	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity