concept

CONNEXIN43

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CONNEXIN43: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

41Connections

0Hypotheses

0Analyses

16Outgoing

2Incoming

0Experiments

No summary available yet. View on Wiki →

💡 Concept Info

Name	CONNEXIN43
Key Genes/Proteins	GJA1
Related Diseases	Ischemic Brain Injury

Wiki Pages (6)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    CONNEXIN43["CONNEXIN43"]
    CONNEXIN43 -->|"expressed in"| Astrocytes["Astrocytes"]
    CONNEXIN43 -->|"interacts"| Hemichannel["Hemichannel"]
    CONNEXIN43 -->|"mediates"| Gap_Junctions["Gap Junctions"]
    CONNEXIN43 -->|"mediates"| Ion_Homeostasis["Ion Homeostasis"]
    CONNEXIN43 -->|"contributes to"| Ischemic_Brain_Injury["Ischemic Brain Injury"]
    CONNEXIN43 -->|"interacts"| P2_RECEPTORS["P2 RECEPTORS"]
    GJA1["GJA1"] -->|"encodes"| CONNEXIN43
    Gap26["Gap26"] -->|"inhibits"| CONNEXIN43
    P2_Receptors["P2 Receptors"] -->|"interacts"| CONNEXIN43

Outgoing (36)

Target	Relation	Type	Str
Astrocytes	expressed_in	cell_type	0.95
Ischemic Brain Injury	contributes_to	disease	0.90
Ischemic Brain Injury	associated_with	disease	0.90
P2 RECEPTORS	interacts_with	receptor	0.90
Apoptotic Cell Death	causes	process	0.85
Apoptosis	causes	process	0.80
MICROGLIA	regulates	cell_type	0.80
cognitive deficits	prevents	process	0.80
functional recovery	improves	process	0.80
MICROGLIA	inhibits	cell_type	0.80
functional recovery	inhibits	process	0.80
ASTROCYTIC	expressed_in	cell_type	0.80
cognitive deficits	mitigates	process	0.80
functional_recovery	inhibition_improves	process	0.80
microglia reactivity	regulates	process	0.60
Alzheimer's disease	therapeutic_target	disease	0.60

Incoming (5)

Source	Relation	Type	Str
GJA1	encodes	gene	0.95
Gap26	inhibits	compound	0.85

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CONNEXIN43

Understanding Entity Pages

Wiki Pages (6)

Gene Page: ANK2 (Ankyrin-2)

Gap Junction Dysfunction Hypothesis in Parkinson's Disease

Neuroimmune-Metabolic Convergence Therapy Synthesis

Connexin and Pannexin Hemichannel Signaling in Neurodegeneration

Connexin/Pannexin Hemichannel Blockade Therapy for Neurodegeneration