Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CROHN'S DISEASE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | CROHN'S DISEASE |
| Key Genes/Proteins | TNF, LRRK2 |
| Related Diseases | RHEUMATOID ARTHRITIS, ALZHEIMER'S DISEASE, CANCER |
Knowledge base pages for this entity
graph TD
CROHN_S_DISEASE["CROHN'S DISEASE"]
CROHN_S_DISEASE -->|"regulates"| INFLAMMATION["INFLAMMATION"]
CROHN_S_DISEASE -->|"implicated in"| OXIDATIVE_STRESS["OXIDATIVE STRESS"]
CROHN_S_DISEASE -->|"regulates"| RHEUMATOID_ARTHRITIS["RHEUMATOID ARTHRITIS"]
CROHN_S_DISEASE -->|"regulates"| TNF["TNF"]
TNF_inhibitors["TNF inhibitors"] -->|"treats"| CROHN_S_DISEASE
PredictSURE_IBD_assay["PredictSURE-IBD assay"] -.biomarker for.-> CROHN_S_DISEASE
Predictsure_Ibd["Predictsure-Ibd"] -.biomarker for.-> CROHN_S_DISEASE
Susceptibility_Loci["Susceptibility Loci"] -.biomarker for.-> CROHN_S_DISEASE
NOD2["NOD2"] -->|"causes"| CROHN_S_DISEASE
Infliximab["Infliximab"] -->|"treats"| CROHN_S_DISEASE
Active_inflammation["Active inflammation"] -->|"involved_in"| CROHN_S_DISEASE
LRRK2["LRRK2"] -->|"risk_factor_for"| CROHN_S_DISEASE| Target | Relation | Type | Str |
|---|---|---|---|
| TNF | interacts_with | gene | 0.65 |
| TNF | associated_with | gene | 0.45 |
| LRRK2 | associated_with | gene | 0.45 |
| INFLAMMATION | regulates | process | 0.35 |
| OXIDATIVE STRESS | implicated_in | process | 0.35 |
| RHEUMATOID ARTHRITIS | regulates | disease | 0.35 |
| TNF | regulates | gene | 0.35 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MACROPHAGE | interacts_with | cell_type | 0.65 |
| MACROPHAGES | associated_with | cell_type | 0.50 |
| ALZHEIMER'S DISEASE | implicated_in | disease | 0.35 |
| CANCER | implicated_in | disease | 0.35 |
| ALZHEIMER'S DISEASE | interacts_with | disease | 0.35 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||