Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Rheumatoid Arthritis: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Associated Genes | MTOR, CANCER, CYTOKINES, ALZHEIMER, INFLAMMATION, ALZHEIMER'S DISEASE, VIRAL INFECTIONS, AUTOPHAGY |
| Therapeutic Agents | Tocilizumab, Shikonin, Columbianadin, Triptolide, Curcumin, 2-Hydroxyestradiol |
| KG Connections | 536 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
Knowledge base pages for this entity
graph TD
Rheumatoid_Arthritis["<b>Rheumatoid Arthritis</b>"]
Als{"Als"}
Rheumatoid_Arthritis -->|"therapeutic_target"| Als
Inflammation{"Inflammation"}
Rheumatoid_Arthritis -->|"therapeutic_target"| Inflammation
INFLAMMATION(["INFLAMMATION"])
INFLAMMATION -->|"therapeutic_target"| Rheumatoid_Arthritis
IL_6(["IL-6"])
IL_6 -->|"therapeutic_target"| Rheumatoid_Arthritis
style Rheumatoid_Arthritis fill:#1a3a4a,stroke:#ef5350,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Als | therapeutic_target | disease | 1.00 |
| Inflammation | therapeutic_target | disease | 1.00 |
| Inflammation | inhibits | disease | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Als | regulates | disease | 1.00 |
| Als | activates | disease | 0.95 |
| Nf-Κb | therapeutic_target | pathway | 0.90 |
| Diabetes | associated_with | disease | 0.85 |
| Als | associated_with | disease | 0.85 |
| Als | inhibits | disease | 0.85 |
| Inflammation | causes | disease | 0.85 |
| Inflammation | regulates | disease | 0.85 |
| Joint Pain | causes | phenotype | 0.85 |
| Neuroinflammation | causes | process | 0.85 |
| Mtor | activates | pathway | 0.80 |
| Autophagy | associated_with | pathway | 0.80 |
| Immune Response | therapeutic_target | pathway | 0.80 |
| Autoimmune | therapeutic_target | disease | 0.75 |
| Cardiovascular | associated_with | disease | 0.75 |
| Cancer | associated_with | disease | 0.75 |
| Inflammation | associated_with | disease | 0.75 |
| Psoriasis | inhibits | disease | 0.75 |
| Inflammatory Bowel Disease | associated_with | disease | 0.75 |
| Core Fucosylation | associated_with | process | 0.75 |
| Alpha-2,6-Sialylation | associated_with | process | 0.75 |
| Immunotherapy | therapeutic_target | pathway | 0.70 |
| Autophagy | activates | pathway | 0.70 |
| Immune Response | causes | pathway | 0.70 |
| Differentiation | activates | pathway | 0.70 |
| Autophagy | implicated_in | pathway | 0.70 |
| Apoptosis | therapeutic_target | pathway | 0.70 |
| Glycolysis | inhibits | pathway | 0.70 |
| Tgf-Β | inhibits | pathway | 0.70 |
| Lipid Metabolism | activates | pathway | 0.70 |
| Immune Response | regulates | pathway | 0.70 |
| Infection | associated_with | disease | 0.65 |
| Aging | associated_with | disease | 0.65 |
| Atherosclerosis | associated_with | disease | 0.65 |
| Inflammatory Bowel Disease | activates | disease | 0.65 |
| Psoriasis | activates | disease | 0.65 |
| Alzheimer | causes | disease | 0.65 |
| Autoimmune | causes | disease | 0.65 |
| Multiple Sclerosis | associated_with | disease | 0.65 |
| Asthma | associated_with | disease | 0.65 |
| Lupus | associated_with | disease | 0.65 |
| Sepsis | associated_with | disease | 0.65 |
| Als | implicated_in | disease | 0.65 |
| Ferroptosis | activates | pathway | 0.60 |
| Mtor | associated_with | pathway | 0.60 |
| Circadian Rhythm | therapeutic_target | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| INFLAMMATION | therapeutic_target | gene | 1.00 |
| IL-6 | therapeutic_target | gene | 1.00 |
| INFLAMMATION | inhibits | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| Autoimmune | associated_with | disease | 1.00 |
| TNF | inhibits | gene | 1.00 |
| CYTOKINES | therapeutic_target | gene | 1.00 |
| Osteoporosis | associated_with | disease | 0.95 |
| INFLAMMATION | causes | gene | 0.95 |
| NF-ΚB | therapeutic_target | gene | 0.95 |
| INFLAMMATION | regulates | gene | 0.95 |
| Columbianadin | treats | compound | 0.95 |
| TNF-α | causes | protein | 0.95 |
| Shikonin | treats | compound | 0.90 |
| Synovial Hyperplasia | contributes_to | phenotype | 0.90 |
| IL-17/NF-κB Signaling Pathway | involved_in | pathway | 0.90 |
| Vav2/Rac-1 Signaling Pathway | involved_in | pathway | 0.90 |
| Beta-Sitosterol | treats | compound | 0.90 |
| Sensory Nerve Growth | contributes_to | process | 0.87 |
| MTOR | activates | gene | 0.85 |
| TNF | activates | gene | 0.85 |
| INFLAMMATION | associated_with | gene | 0.85 |
| AUTOPHAGY | associated_with | gene | 0.85 |
| AKT | inhibits | gene | 0.85 |
| ERK | inhibits | gene | 0.85 |
| Triptolide | treats | drug | 0.85 |
| Curcumin | treats | drug | 0.85 |
| 2-Hydroxyestradiol | treats | compound | 0.85 |
| Brain-Spleen Axis | involved_in | mechanism | 0.85 |
| IL6 | associated_with | protein | 0.80 |
| Tocilizumab | treats | drug | 0.80 |
| IL-17 | biomarker_for | protein | 0.80 |
| TNF-α | biomarker_for | protein | 0.78 |
| CANCER | therapeutic_target | gene | 0.75 |
| AKT | activates | gene | 0.75 |
| CANCER | associated_with | gene | 0.75 |
| GENES | therapeutic_target | gene | 0.75 |
| CYTOKINES | associated_with | gene | 0.75 |
| TNF-Α | activates | gene | 0.75 |
| CD4 | activates | gene | 0.75 |
| Tumor | activates | disease | 0.75 |
| AUTOPHAGY | activates | gene | 0.75 |
| AGING | associated_with | gene | 0.75 |
| PTEN | inhibits | gene | 0.75 |
| PI3K | inhibits | gene | 0.75 |
| JNK | inhibits | gene | 0.75 |
| P38 | inhibits | gene | 0.75 |
| TNF-Α | inhibits | gene | 0.75 |
| Tumor | inhibits | disease | 0.75 |
| CYTOKINES | activates | gene | 0.75 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||