concept

MACROPHAGE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MACROPHAGE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2321Connections

1Hypotheses

2Analyses

50Outgoing

50Incoming

Summary

MACROPHAGE is a concept in neurodegeneration research. Key relationships include: co discussed, activates, regulates. Associated with ALZHEIMER, ALZHEIMER'S, ALZHEIMER'S DISEASE. Connected to 293 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	MACROPHAGE
Key Genes/Proteins	NF-KB, CHRNA7, AKT, IL-6, Annexin A1
Related Diseases	PARKINSON'S DISEASE, ALZHEIMER'S DISEASE
Linked Hypotheses	1 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    MACROPHAGE["MACROPHAGE"]
    MACROPHAGE -->|"activates"| glioblastoma["glioblastoma"]
    MACROPHAGE -->|"regulates"| INFLAMMATORY_RESPONSE["INFLAMMATORY_RESPONSE"]
    SQSTM1["SQSTM1"] -->|"expressed in"| MACROPHAGE
    BECN1["BECN1"] -->|"expressed in"| MACROPHAGE
    autophagy["autophagy"] -->|"regulates"| MACROPHAGE
    LOX["LOX"] -->|"activates"| MACROPHAGE
    P2RY12["P2RY12"] -->|"expressed in"| MACROPHAGE
    TMEM119["TMEM119"] -->|"expressed in"| MACROPHAGE
    GAIN["GAIN"] -->|"expressed in"| MACROPHAGE
    MICROGLIA["MICROGLIA"] -->|"expressed in"| MACROPHAGE

Outgoing (435)

Target	Relation	Type	Str
ATHEROSCLEROSIS	contributes_to	entity	0.90
IRON METABOLISM	involved_in	entity	0.90
TREM2	expressed_in	entity	0.85
P2RY12	expressed_in	entity	0.85
INFLAMMATION	mediates	entity	0.85
CELL DEATH	activates	phenotype	0.70
HDAC3	exacerbates	gene	0.70
NEURODEGENERATION	regulates	disease	0.65
TUMOR	biomarker_for	disease	0.65
NEUTROPHIL	increases	cell_type	0.65
NEURON	accumulates_in	cell_type	0.65
MTOR	interacts_with	gene	0.65
NEURON	protects_against	cell_type	0.65
NEURONS	protects_against	cell_type	0.65
UBIQUITIN	activates	gene	0.65
STING	regulates	gene	0.65
MACROPHAGES	sensitizes_to	cell_type	0.65
NEURON	contributes_to	cell_type	0.65
PARKIN	inhibits	gene	0.65
PINK1	inhibits	gene	0.65
NRF2	activates	gene	0.65
P62	activates	gene	0.65
PI3K	activates	gene	0.65
PI3K	promotes	gene	0.65
MONOCYTE	interacts_with	cell_type	0.65
MONOCYTES	interacts_with	cell_type	0.65
MACROPHAGES	accumulates_in	cell_type	0.65
MACROPHAGES	increases	cell_type	0.65
MACROPHAGES	reduces	cell_type	0.65
MONOCYTE	sensitizes_to	cell_type	0.65
MONOCYTES	sensitizes_to	cell_type	0.65
TUMOR	increases	disease	0.65
NFKB	associated_with	gene	0.65
MONOCYTE	causes	cell_type	0.65
MICROGLIA	reduces	cell_type	0.65
NAD	activates	gene	0.65
MICROGLIA	treats	cell_type	0.65
QUERCETIN	protects_against	drug	0.65
ROS	mediates	gene	0.65
ROS	regulates	gene	0.65
ROS	activates	gene	0.65
UBIQUITIN	ubiquitinates	gene	0.65
NRF2	phosphorylates	gene	0.65
P62	phosphorylates	gene	0.65
ROS	phosphorylates	gene	0.65
RESVERATROL	targets	drug	0.65
NICOTINAMIDE	expressed_in	drug	0.65
T CELL	interacts_with	cell_type	0.65
MAST CELL	contributes_to	cell_type	0.65
T CELL	contributes_to	cell_type	0.65

Incoming (1886)

Source	Relation	Type	Str
NF-KB	associated_with	protein	1.00
PARKINSON'S DISEASE	associated_with	disease	1.00
ALZHEIMER'S DISEASE	associated_with	disease	1.00
MICROGLIA	associated_with	cell_type	1.00
MICROGLIA	activates	cell_type	0.90
HK2	expressed_in	entity	0.90
CHRNA7	expressed_on	gene	0.90
CNS NICHE	modulates	entity	0.85
AKT	activates	gene	0.82
IL-6	associated_with	gene	0.82
MTOR	activates	gene	0.82
IL10	regulates	entity	0.80
Annexin A1	regulates	protein	0.80
UBIQUITIN	associated_with	protein	0.74
MICROGLIA	regulates	cell_type	0.74
TET2	causes	gene	0.70
MTOR	regulates	gene	0.66
ERK	activates	gene	0.66
AMYLOID	associated_with	protein	0.66
TREM2	activates	gene	0.66
P62	activates	protein	0.66
TREM2	associated_with	gene	0.66
TNF	associated_with	gene	0.66
MICROGLIA	inhibits	cell_type	0.66
APOE	associated_with	gene	0.66
CSF1R	activates	gene	0.65
CSF1R	regulates	gene	0.65
CANCER	treats	disease	0.65
GLIOBLASTOMA	treats	disease	0.65
CANCER	biomarker_for	disease	0.65
ATHEROSCLEROSIS	promotes	disease	0.65
ATHEROSCLEROSIS	associated_with	disease	0.65
LC3	associated_with	gene	0.65
LRRK2	inhibits	gene	0.65
ALZHEIMER	associated_with	disease	0.65
ALZHEIMER'S	associated_with	disease	0.65
GLIOMA	mediates	disease	0.65
GLIOMA	promotes	disease	0.65
AKT	promotes	gene	0.65
ISCHEMIC	targets	disease	0.65
CX3CR1	inhibits	gene	0.65
HSP90	protects_against	gene	0.65
ATHEROSCLEROSIS	processes	disease	0.65
ISCHEMIA	contributes_to	disease	0.65
CD38	promotes	gene	0.65
IL-10	promotes	gene	0.65
IL-6	promotes	gene	0.65
FIBROSIS	targets	disease	0.65
NEURONS	regulates	cell_type	0.65
HEPATITIS	regulates	disease	0.65

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
IL-10-Producing B10 Cells Establish AQP4-Specific Peripheral	0.601	neuroinflammation	How do B cells mechanistically orchestra

Mentioning Analyses (2)

Scientific analyses that reference this entity

How do perivascular cells specifically recognize and respond to amyloid-β to upr

neurodegeneration | 2026-04-06 | 0 hypotheses

Systemic immune profiling and peripheral immune contributions to neurodegenerati

neurodegeneration | 2026-04-04 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

MACROPHAGE

Understanding Entity Pages

Summary

Wiki Pages (20)

Novel Therapy Index

Parkinson's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Atypical Parkinsonism

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

neuroinflammation

Microglial Cells — Cell Type Hierarchy

TREM2 Mechanism Hub

CLCN10 — Chloride Voltage-Gated Channel 10

TREM2 Microglial Signaling Pathway in Neurodegeneration

omega-3-fatty-acids-neurodegeneration

Melatonin for Tauopathy: Comprehensive Evidence Synthesis

nlrc5-protein

Niemann-Pick Disease Type C (NPC)

Excitotoxicity in Neurodegeneration

Curcumin for Neurodegeneration

Microglial Senescence Pathway in Neurodegeneration

Multiple Sclerosis (MS)

gba

NF-kB Signaling Pathway in Neurodegeneration