gene

SMAD3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SMAD3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

375Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

SMAD3 is a transcription factor and key mediator of TGF-β signaling, implicated in Alzheimer's Disease, Parkinson's Disease, and Loeys-Dietz syndrome.

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🧬 Gene Info

Gene Symbol	SMAD3
Full Name	SMAD Family Member 3
Chromosome	15q22.33
Protein Type	Transcription Factor
Function	encodes a transcription factor that serves as a central mediator of TGF-β (Transforming Growth Factor Beta) signaling.
Primary Expression	Brain (cortex, hippocampus, substantia nigra), Lung, Heart, Blood vessels
Molecular Weight	48 kDa
Pathways	TGF-β, TGF-β signaling
UniProt ID	P84022
NCBI Gene ID	4088
Ensembl ID	ENSG00000166949
OMIM	603109
GeneCards	SMAD3
Human Protein Atlas	SMAD3
Associated Diseases	ALS, Aging, Alzheimer, Crohn'S Disease, Diabetes
Known Drugs/Compounds	lycopene
Interactions	ADAMTS4, AKT, BNIP3L, LC3, TNF, BRD4
KG Connections	374 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SMAD3 — AlphaFold P84022 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SMAD3["SMAD3"]
    SMAD3 -->|"regulates"| mitophagy["mitophagy"]
    SMAD3 -->|"activates"| Aging["Aging"]
    SMAD3 -->|"activates"| Ms["Ms"]
    SMAD3 -->|"activates"| Inflammation["Inflammation"]
    SMAD3 -->|"expressed in"| Fibrosis["Fibrosis"]
    SMAD3 -->|"target for"| Stroke["Stroke"]
    SMAD3 -->|"activates"| Diabetes["Diabetes"]
    lycopene["lycopene"] -->|"inhibits"| SMAD3
    BMAL1["BMAL1"] -->|"activates"| SMAD3
    ADAMTS4["ADAMTS4"] -->|"activates"| SMAD3
    SQSTM1["SQSTM1"] -->|"expressed in"| SMAD3
    MAP1LC3["MAP1LC3"] -->|"expressed in"| SMAD3
    P62["P62"] -->|"expressed in"| SMAD3
    PINK1["PINK1"] -->|"expressed in"| SMAD3
    BNIP3["BNIP3"] -->|"activates"| SMAD3
    GENES["GENES"] -->|"activates"| SMAD3

Outgoing (259)

Target	Relation	Type	Str
Pericytes	expressed_in	cell_type	0.95
mitophagy	regulates	pathway	0.90
Crohn'S Disease	associated_with	disease	0.85
Crohn's Disease	risk_factor_for	disease	0.85
Inflammation	activates	disease	0.85
Alzheimer's Disease	biomarker_for	disease	0.85
Renal Fibrosis	involved_in	disease	0.80
Treg differentiation	promotes	process	0.80
TGF-beta signaling	participates_in	pathway	0.80
Tgf-Β	activates	pathway	0.80
Als	expressed_in	disease	0.75
Cancer	expressed_in	disease	0.75
Als	regulates	disease	0.75
Tumor	regulates	disease	0.75
Tumor	inhibits	disease	0.75
Cancer	inhibits	disease	0.75
Hepatic Fibrosis	activates	disease	0.70
Mitophagy	activates	pathway	0.70
Tgf-Β	inhibits	pathway	0.70
INFLAMMATION	activates	gene	0.70
CANCER	inhibits	gene	0.70
stem cells	expressed_in	cell_type	0.70
oxidative stress response	participates_in	pathway	0.70
CANCER	interacts_with	disease	0.70
TGF	inhibits	gene	0.70
Ms	associated_with	disease	0.65
Als	associated_with	disease	0.65
Aging	activates	disease	0.65
Ms	activates	disease	0.65
Fibrosis	expressed_in	disease	0.65
Inflammation	inhibits	disease	0.65
Fibrosis	inhibits	disease	0.65
Stroke	therapeutic_target	disease	0.65
Diabetes	activates	disease	0.65
Fibrosis	activates	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Alzheimer	activates	disease	0.65
Cardiovascular	activates	disease	0.65
Parkinson	activates	disease	0.65
Aging	therapeutic_target	disease	0.65
Metabolic Syndrome	therapeutic_target	disease	0.65
Als	activates	disease	0.65
Diabetes	associated_with	disease	0.65
Als	inhibits	disease	0.65
Ms	expressed_in	disease	0.65
Carcinoma	activates	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Leukemia	activates	disease	0.65
ALS	associated_with	disease	0.65

Incoming (116)

Source	Relation	Type	Str
lycopene	inhibits	drug	0.80
SMAD2	regulates	gene	0.70
STAT3	activates	gene	0.70
MITOPHAGY	activates	gene	0.70
AGING	causes	phenotype	0.65
TYK2	associated_with	gene	0.60
IL10	associated_with	gene	0.60
DNMT3A	associated_with	gene	0.60
BMAL1	activates	gene	0.60
ADAMTS4	activates	gene	0.60
SQSTM1	expressed_in	gene	0.60
P62	expressed_in	gene	0.60
PINK1	expressed_in	gene	0.60
BNIP3	activates	gene	0.60
TGFB1	activates	gene	0.60
FUNDC1	activates	gene	0.60
BACE1	activates	gene	0.60
NLRP3	activates	gene	0.60
SIRT1	therapeutic_target	gene	0.60
PARKIN	expressed_in	gene	0.60
SMAD2	expressed_in	gene	0.60
AKT	activates	gene	0.60
PP2A	regulates	gene	0.60
BNIP3L	activates	gene	0.60
SMAD4	regulates	gene	0.60
CAV1	regulates	gene	0.60
TRAF2	regulates	gene	0.60
HK2	biomarker_for	gene	0.60
SOX2	activates	gene	0.60
LIFR	activates	gene	0.60
LIF	activates	gene	0.60
EP300	activates	gene	0.60
PLK1	inhibits	gene	0.60
TERT	inhibits	gene	0.60
SLC7A11	inhibits	gene	0.60
WWOX	activates	gene	0.60
TAU	inhibits	gene	0.60
TGFBR2	expressed_in	gene	0.60
SMAD7	regulates	gene	0.60
PRKN	expressed_in	gene	0.60
LC3	expressed_in	gene	0.60
LC3	activates	gene	0.60
FOXO3	regulates	gene	0.60
OVERVIEW	regulates	gene	0.60
VEGFA	interacts_with	gene	0.60
SMAD2	associated_with	gene	0.60
ACTB	activates	gene	0.60
DNMT3A	implicated_in	gene	0.60
IL10	implicated_in	gene	0.60
STAT3	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SMAD3

Understanding Entity Pages

Summary

Wiki Pages (21)

SMAD3 — SMAD Family Member 3

TGF-β Signaling in Parkinson's Disease

TGF-beta Signaling Pathway in Neurodegeneration

BMPR1A — Bone Morphogenetic Protein Receptor Type 1A

ACVR1 Gene

Pericytes

SMAD7 Gene

PPM1A Protein

AXIN1 Protein

ACVR2B Gene

TGF-β1 Protein

TGF-beta Signaling Pathway in Neurodegeneration

TGF-beta Signaling in CBS/PSP

tgf-beta-modulation-therapy

TGFBR2 Protein — Transforming Growth Factor Beta Receptor 2

FOXM1 Gene

TGF-beta Signaling Therapies for Neurodegeneration

TGFBR1 — Transforming Growth Factor Beta Receptor 1

TGFBR2 — Transforming Growth Factor Beta Receptor 2