gene

MAPK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAPK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

890Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

MAPK1 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, interacts with, associated with. Associated with Aging, Als, Alzheimer. Connected to 273 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	MAPK1
Protein Family	MAP kinase family, CMGC group
Protein Type	Kinase
Function	is a protein involved in various cellular processes relevant to neurodegeneration.
Subcellular Localization	Cytoplasm, nucleus
Molecular Weight	41 kDa
Amino Acids	360 aa
Pathways	MAPK, Mapk, MAPK signaling, MAPK pathway
UniProt ID	P28482
GeneCards	MAPK1
Human Protein Atlas	MAPK1
Associated Diseases	Aging, Als, Alzheimer, Cancer, Carcinoma
Known Drugs/Compounds	Chrysotoxine, DEP, DMP, DOP, Zuojin Pill
Interactions	ACTB, ACTG1, Actin, ACVR1, AIFM1, AKT
KG Connections	889 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: MAPK1 — AlphaFold P28482 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (12)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    MAPK1["MAPK1"]
    MAPK1 -->|"interacts"| APP["APP"]
    MAPK1 -->|"inhibits"| Inflammation["Inflammation"]
    MAPK1 -->|"inhibits"| Als["Als"]
    MAPK1 -->|"inhibits"| Ms["Ms"]
    MAPK1 -->|"activates"| Dementia["Dementia"]
    MAPK1 -->|"activates"| Alzheimer["Alzheimer"]
    MAPK1 -->|"target for"| Cancer["Cancer"]
    FOXO3["FOXO3"] -->|"inhibits"| MAPK1
    PI3K["PI3K"] -->|"inhibits"| MAPK1
    APP -->|"activates"| MAPK1
    NFKB1["NFKB1"] -->|"target for"| MAPK1
    ERK["ERK"] -->|"target for"| MAPK1
    TRIM24["TRIM24"] -->|"target for"| MAPK1
    TDP1["TDP1"] -->|"target for"| MAPK1
    MAP1LC3B["MAP1LC3B"] -->|"inhibits"| MAPK1

Outgoing (541)

Target	Relation	Type	Str
MAPK1	encodes	protein	0.00
Breast Cancer	involved_in	disease	0.90
Neurodegeneration	involved_in	process	0.90
Mapk	therapeutic_target	pathway	0.90
TP53	interacts_with	protein	0.89
immunosuppression	upstream_of	process	0.85
Breast Cancer Pathogenesis	involved_in	process	0.85
Hepatocellular Carcinoma	activates	disease	0.80
Zuojin Pill	inhibits	drug	0.80
Wnt signaling	participates_in	pathway	0.80
AKT	therapeutic_target	gene	0.80
GENES	therapeutic_target	gene	0.80
Mapk	activates	pathway	0.80
Als	interacts_with	disease	0.75
Cancer	therapeutic_target	disease	0.75
APP	interacts_with	protein	0.71
STAT3	associated_with	gene	0.70
PIK3CA	targets	gene	0.70
AUTOPHAGY	activates	gene	0.70
Mapk	associated_with	pathway	0.70
Autophagy	activates	pathway	0.70
NETO2	activates	gene	0.70
Apoptosis	therapeutic_target	pathway	0.70
Mapk	interacts_with	pathway	0.70
Nf-Κb	therapeutic_target	pathway	0.70
PI3K	treats	gene	0.70
PIK3CA	associated_with	gene	0.70
PI3K-AKT-mTOR signaling	participates_in	pathway	0.70
apoptosis pathway	participates_in	pathway	0.70
Pi3K/Akt	therapeutic_target	pathway	0.70
Prion	therapeutic_target	disease	0.65
Ischemia	inhibits	disease	0.65
Depression	causes	disease	0.65
Fibrosis	causes	disease	0.65
Diabetes	associated_with	disease	0.65
Stroke	inhibits	disease	0.65
ALS	associated_with	disease	0.65
Carcinoma	implicated_in	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Aging	implicated_in	disease	0.65
Cancer	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
ALS	causes	disease	0.65
Alzheimer	associated_with	disease	0.65
Aging	inhibits	disease	0.65
Hypertension	inhibits	disease	0.65
Inflammation	causes	disease	0.65
Lung Cancer	therapeutic_target	disease	0.65
Lymphoma	activates	disease	0.65
Inflammation	expressed_in	disease	0.65

Incoming (349)

Source	Relation	Type	Str
MAPK1	encodes	gene	0.00
Cyclosporine A	upregulates	drug	0.92
FGF2	activates	protein	0.90
DEP	binds	compound	0.90
KDEL	phosphorylates	receptor	0.88
FGF2 mutant (K119E/R120E/K125E)	inhibits	protein	0.85
DMP	binds	compound	0.85
DOP	binds	compound	0.85
Chrysotoxine	targets	compound	0.80
PRKCD	associated_with	gene	0.80
EGFR	activates	gene	0.80
TERT	activates	gene	0.80
PI3K	therapeutic_target	gene	0.80
MYC	associated_with	gene	0.78
MTOR	interacts_with	protein	0.75
MAPK3	therapeutic_target	gene	0.70
MAPK3	activates	gene	0.70
NFE2L2	interacts_with	gene	0.70
MAPK3	associated_with	gene	0.70
RAF1	therapeutic_target	gene	0.60
NLRP3	activates	gene	0.60
ESR1	interacts_with	gene	0.60
IL6	regulates	gene	0.60
AKT	regulates	gene	0.60
MYD88	inhibits	gene	0.60
TNF	regulates	gene	0.60
NLRP3	inhibits	gene	0.60
IL1B	regulates	gene	0.60
CASP3	regulates	gene	0.60
AKT1	treats	gene	0.60
CASP3	treats	gene	0.60
IL1B	treats	gene	0.60
IL6	treats	gene	0.60
AKT	co_discussed	gene	0.60
JAK2	co_discussed	gene	0.60
CASP3	co_discussed	gene	0.60
IL1B	co_discussed	gene	0.60
IL6	co_discussed	gene	0.60
BDNF	associated_with	gene	0.60
APOE	co_discussed	gene	0.60
CLU	co_discussed	gene	0.60
GFAP	co_discussed	gene	0.60
LRP1	co_discussed	gene	0.60
BACE1	co_discussed	gene	0.60
GSK3B	co_discussed	gene	0.60
BCL2	associated_with	gene	0.60
APP	co_discussed	gene	0.60
LRRK2	co_discussed	gene	0.60
AKT	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning MAPK1 in their description or question text

No additional research found

MAPK1

Understanding Entity Pages

Summary

Wiki Pages (12)

MAPK1 Gene

MAPK10 Gene

MAPK14 — Mitogen-Activated Protein Kinase 14 (p38α)

JNK3 (MAPK10)

MAPK10 Protein (JNK3)

ERK2 (MAPK1)

MAPK14 Protein

MAPK11 Protein (p38β)

MAPK11

MAPK13 — Mitogen-Activated Protein Kinase 13

MAPK12

MAPK1 Protein (ERK2)