gene

MAPK1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAPK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

948Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

MAPK1 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, interacts with, associated with. Associated with Aging, Als, Alzheimer. Connected to 273 entities in the SciDEX knowledge graph.

View on Wiki →

🧬 Gene Info

Gene Symbol	MAPK1
Full Name	Mitogen-Activated Protein Kinase 1
Chromosome	22q11.22
Protein Family	MAP kinase family, CMGC group
Protein Type	Kinase
Function	is a protein involved in various cellular processes relevant to neurodegeneration.
Subcellular Localization	Cytoplasm, nucleus
Molecular Weight	41 kDa
Amino Acids	360 aa
Pathways	MAPK, Mapk, MAPK signaling, MAPK pathway
UniProt ID	P28482
NCBI Gene ID	5594
Ensembl ID	ENSG00000100030
OMIM	176948
GeneCards	MAPK1
Human Protein Atlas	MAPK1
Associated Diseases	ALS, Aging, Alzheimer, Cancer, Carcinoma
Known Drugs/Compounds	Zuojin Pill, Chrysotoxine, DEP, DMP, DOP
Interactions	MAP1LC3B, MTOR, TLR4, LC3, TFEB, AKT
KG Connections	948 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: MAPK1 — AlphaFold P28482 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    MAPK1["MAPK1"]
    MAPK1 -->|"interacts"| APP["APP"]
    MAPK1 -->|"inhibits"| Inflammation["Inflammation"]
    MAPK1 -->|"inhibits"| Als["Als"]
    MAPK1 -->|"inhibits"| Ms["Ms"]
    MAPK1 -->|"activates"| Dementia["Dementia"]
    MAPK1 -->|"activates"| Alzheimer["Alzheimer"]
    MAPK1 -->|"target for"| Cancer["Cancer"]
    FOXO3["FOXO3"] -->|"inhibits"| MAPK1
    PI3K["PI3K"] -->|"inhibits"| MAPK1
    APP -->|"activates"| MAPK1
    NFKB1["NFKB1"] -->|"target for"| MAPK1
    ERK["ERK"] -->|"target for"| MAPK1
    TRIM24["TRIM24"] -->|"target for"| MAPK1
    TDP1["TDP1"] -->|"target for"| MAPK1
    MAP1LC3B["MAP1LC3B"] -->|"inhibits"| MAPK1

Outgoing (565)

Target	Relation	Type	Str
Neurodegeneration	involved_in	process	0.90
Breast Cancer	involved_in	disease	0.90
Mapk	therapeutic_target	pathway	0.90
TP53	interacts_with	protein	0.89
immunosuppression	upstream_of	process	0.85
Breast Cancer Pathogenesis	involved_in	process	0.85
Zuojin Pill	inhibits	drug	0.80
Hepatocellular Carcinoma	activates	disease	0.80
Wnt signaling	participates_in	pathway	0.80
AKT	therapeutic_target	gene	0.80
Mapk	activates	pathway	0.80
GENES	therapeutic_target	gene	0.80
Cancer	therapeutic_target	disease	0.75
Als	interacts_with	disease	0.75
APP	interacts_with	protein	0.71
NETO2	activates	gene	0.70
PI3K	treats	gene	0.70
STAT3	associated_with	gene	0.70
PIK3CA	targets	gene	0.70
PIK3CA	associated_with	gene	0.70
Autophagy	activates	pathway	0.70
Nf-Κb	therapeutic_target	pathway	0.70
AUTOPHAGY	activates	gene	0.70
Mapk	associated_with	pathway	0.70
Mapk	interacts_with	pathway	0.70
Apoptosis	therapeutic_target	pathway	0.70
Pi3K/Akt	therapeutic_target	pathway	0.70
PI3K-AKT-mTOR signaling	participates_in	pathway	0.70
apoptosis pathway	participates_in	pathway	0.70
Inflammation	inhibits	disease	0.65
Als	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Dementia	activates	disease	0.65
Alzheimer	activates	disease	0.65
Ms	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Ms	interacts_with	disease	0.65
Atherosclerosis	interacts_with	disease	0.65
Als	associated_with	disease	0.65
Cancer	activates	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Huntington	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Ms	associated_with	disease	0.65
Autism	expressed_in	disease	0.65
Tumor	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
Carcinoma	interacts_with	disease	0.65
Als	activates	disease	0.65

Incoming (383)

Source	Relation	Type	Str
Cyclosporine A	upregulates	drug	0.92
DEP	binds	compound	0.90
FGF2	activates	protein	0.90
KDEL	phosphorylates	receptor	0.88
DMP	binds	compound	0.85
DOP	binds	compound	0.85
FGF2 mutant (K119E/R120E/K125E)	inhibits	protein	0.85
PRKCD	associated_with	gene	0.80
EGFR	activates	gene	0.80
TERT	activates	gene	0.80
Chrysotoxine	targets	compound	0.80
PI3K	therapeutic_target	gene	0.80
MYC	coexpressed_with	gene	0.78
MTOR	interacts_with	protein	0.75
MAPK3	associated_with	gene	0.70
MAPK3	activates	gene	0.70
MAPK3	therapeutic_target	gene	0.70
NFE2L2	interacts_with	gene	0.70
FOXO3	inhibits	gene	0.60
PI3K	inhibits	gene	0.60
APP	activates	gene	0.60
NFKB1	therapeutic_target	gene	0.60
TRIM24	therapeutic_target	gene	0.60
TDP1	therapeutic_target	gene	0.60
MAP1LC3B	inhibits	gene	0.60
TLR4	inhibits	gene	0.60
MTOR	inhibits	gene	0.60
MAPK3	regulates	gene	0.60
MMP9	associated_with	gene	0.60
CCT2	interacts_with	gene	0.60
GFAP	interacts_with	gene	0.60
GRIA1	interacts_with	gene	0.60
SNAP25	interacts_with	gene	0.60
ACTG1	interacts_with	gene	0.60
SNCA	interacts_with	gene	0.60
GAPDH	interacts_with	gene	0.60
MTOR	activates	gene	0.60
SRC	interacts_with	gene	0.60
AKT1	associated_with	gene	0.60
FOS	associated_with	gene	0.60
IL6	interacts_with	gene	0.60
FAS	regulates	gene	0.60
PIK3CA	associated_with	gene	0.60
RANKINGS	associated_with	gene	0.60
RAC1	interacts_with	gene	0.60
MAP2K1	associated_with	gene	0.60
IGF1	associated_with	gene	0.60
SRC	associated_with	gene	0.60
IGF1R	associated_with	gene	0.60
JAK2	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

MAPK1

Understanding Entity Pages

Summary

Wiki Pages (21)

MAPK1 Gene

rankings

RASGRP1 Gene

erk-mapk-signaling-neurodegeneration

ERK1 Protein

ERK2 Protein

APP Protein

PRKCD — Protein Kinase C Delta

GDNF Family Neurotrophic Factor Signaling Pathway in Neurodegeneration

NTF5 — Neurotrophin 5

AGER/RAGE Protein

MAP2K2 Gene

ARRB2 — Arrestin Beta 2

MEKK2 Protein

Mechanism Rankings

Treatment Rankings

GFRA4 - GDNF Family Receptor Alpha 4

TRPA1 Gene

MAPK4 Gene