gene 1,819 words KG: DEPTOR 2026-03-27
kind:genesection:genesstate:published
Contents

DEPTOR

🧬 Gene Info
Gene SymbolDEPTOR
AliasesDEP domain-containing mTOR interacting protein
Chromosome8q24.3
Functionis an endogenous inhibitor of both mechanistic target of rapamycin complex 1 (mTORC1) and mTORC2.
Primary Expressionneurons and glia, where it plays important roles in regulating autophagy, synaptic plasticity, and cellular stress responses
Molecular Weight46 kDa
Amino Acids409 aa
Exons11
PathwaysMTOR, mTOR, mTOR signaling
Ensembl IDENSG00000155792
GeneCardsDEPTOR
Human Protein AtlasDEPTOR
Associated Diseasesneurodegeneration
Known Drugs/Compoundsrapamycin
InteractionsHMGB1, EGF, MLST8, RICTOR, MTOR, PIK3C3
KG Connections308 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (7)

APOE-Dependent Autophagy Restoration
Score: 0.61
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.40
TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.40
Digital Twin-Guided Metabolic Reprogramming
Score: 0.61
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.57

Related Analyses (4)

Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Gene expression changes in aging mouse brain predicting neur
neurodegeneration · archived
Metabolic reprogramming in neurodegenerative disease
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (5)

Anti-Tau Antibody vs ASO/Gene Therapy — Comparative Efficacy
validation · proposed · Score: 0.40
Epigenetic Dysregulation Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40
Synaptic Mitochondrial Resilience Enhancement for Parkinson'
validation · proposed · Score: 0.40
Tau ASO Therapy
validation · proposed · Score: 0.40

See Also (14)

Packard Center for ALS Research
institution · KG edge: interacts_with
cGAS-STING Pathway Dysregulation Hypothesis in Parkinso
hypothesis · KG edge: interacts_with
CFTR Gene
gene · KG edge: interacts_with
casp3
gene · KG edge: interacts_with
CALCOCO2 — Calcium Binding and Coiled-Coil Domain 2
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

DEPTOR phosphorylates EGF
DEPTOR phosphorylates EGFR
DEPTOR phosphorylates EIF2A
DEPTOR phosphorylates EIF2AK3
DEPTOR phosphorylates ERN1
DEPTOR phosphorylates FIP200
DEPTOR phosphorylates GABARAP
DEPTOR phosphorylates GRB2
DEPTOR phosphorylates HMGB1
DEPTOR phosphorylates HSP70