gene

DNAJC12

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DNAJC12: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

12Connections

0Hypotheses

0Analyses

10Outgoing

2Incoming

0Experiments

0Debates

Summary

Page for DNAJC12 Gene

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🧬 Gene Info

Gene Symbol	DNAJC12
Chromosome	10q22.1.
Protein Type	Chaperone
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	34.2 kDa
Amino Acids	305 aa
Ensembl ID	ENSG00000156026
GeneCards	DNAJC12
Human Protein Atlas	DNAJC12
Brain	High expression in cerebral cortex, hippocampus (CA1-CA3 regions), cerebellar cortex, basal ganglia, and brainstem nuclei
Peripheral tissues	Moderate expression in liver, kidney, pancreas, and testis
Cellular localization	Primarily cytosolic, with partial ER and mitochondrial localization
Developmental regulation	Expression increases during neuronal maturation
Associated Diseases	neurodegeneration
Interactions	AKT, APOPTOSIS, Caspase, FERROPTOSIS, GPX4, HSP70
KG Connections	12 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

DNAJC12 Gene

gene · 804 words

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DNAJC12 Protein

protein · 1002 words

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Pathway Diagram

graph TD
    DNAJC12["DNAJC12"]
    Ferroptosis{"Ferroptosis"}
    DNAJC12 -->|"inhibits"| Ferroptosis
    Cancer{"Cancer"}
    DNAJC12 -->|"activates"| Cancer
    Als{"Als"}
    DNAJC12 -->|"activates"| Als
    HSP70["HSP70"]
    DNAJC12 -->|"activates"| HSP70
    RNA["RNA"]
    DNAJC12 -->|"activates"| RNA
    FERROPTOSIS["FERROPTOSIS"]
    DNAJC12 -->|"inhibits"| FERROPTOSIS
    APOPTOSIS["APOPTOSIS"]
    DNAJC12 -->|"inhibits"| APOPTOSIS
    SLC7A11["SLC7A11"]
    DNAJC12 -->|"inhibits"| SLC7A11
    Apoptosis(["Apoptosis"])
    DNAJC12 -->|"inhibits"| Apoptosis
    Caspase("Caspase")
    DNAJC12 -->|"inhibits"| Caspase
    AKT["AKT"]
    AKT -->|"activates"| DNAJC12
    GPX4["GPX4"]
    GPX4 -->|"inhibits"| DNAJC12
    neurodegeneration["neurodegeneration"]
    DNAJC12 -->|"implicated_in"| neurodegeneration

Outgoing (10)

Target	Relation	Type	Str
Als	activates	disease	0.65
Ferroptosis	inhibits	disease	0.65
Cancer	activates	disease	0.65
FERROPTOSIS	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
Apoptosis	inhibits	pathway	0.60
HSP70	activates	gene	0.60
Caspase	inhibits	protein	0.60
SLC7A11	inhibits	gene	0.60
RNA	activates	gene	0.60

Incoming (2)

Source	Relation	Type	Str
AKT	activates	gene	0.60
GPX4	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DNAJC12 in their description or question text

No additional research found