protein

CR1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

600Connections

15Hypotheses

2Analyses

50Outgoing

50Incoming

9Experiments

3Debates

Summary

CR1 is a protein involved in neurodegeneration research. Key relationships include: associated with, regulates, co discussed. Associated with ALS, Aging, Als. Connected to 128 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	CR1
Full Name	Complement Component 1q Receptor
Chromosome	1q32
Protein Type	Receptor
Function	is a gene located on chromosome 1q32.
Primary Expression	Blood cells (erythrocytes, leukocytes), Brain (microglia, astrocytes), Kidney, Spleen
Molecular Weight	250 kDa
Amino Acids	1998 aa
Exons	38
Pathways	Apoptosis, Autophagy, Blood-Brain Barrier, Complement, Dysbiosis
UniProt ID	P08578
NCBI Gene ID	1378
Ensembl ID	ENSG00000203797
OMIM	120600
GeneCards	CR1
Human Protein Atlas	CR1
Associated Diseases	Aging, Als, Alzheimer, Alzheimer's disease, CELL SURVIVAL
Known Drugs/Compounds	Stem Cell Therapy
Interactions	ABCA7, Actin, AD, AGING, ALZHEIMER, ALZHEIMER DISEASE
KG Connections	600 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CR1 — AlphaFold P08578 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (15)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CR1["CR1"]
    Amyloid_beta_42["Amyloid-beta 42"]
    CR1 -->|"regulates"| Amyloid_beta_42
    complement_receptor_1["complement receptor 1"]
    CR1 -->|"encodes"| complement_receptor_1
    Neurodegeneration{"Neurodegeneration"}
    CR1 -->|"associated with"| Neurodegeneration
    Multiple_Sclerosis{"Multiple Sclerosis"}
    CR1 -->|"associated with"| Multiple_Sclerosis
    Als{"Als"}
    CR1 -->|"associated with"| Als
    Aging{"Aging"}
    CR1 -->|"associated with"| Aging
    Ms{"Ms"}
    CR1 -->|"associated with"| Ms
    Alzheimer{"Alzheimer"}
    CR1 -->|"associated with"| Alzheimer
    MICROGLIA["MICROGLIA"]
    CR1 -->|"associated with"| MICROGLIA
    SYNAPSE["SYNAPSE"]
    CR1 -->|"associated with"| SYNAPSE
    TAU["TAU"]
    CR1 -->|"associated with"| TAU
    Dementia{"Dementia"}
    CR1 -->|"associated with"| Dementia
    rs6656401["rs6656401"]
    rs6656401 -->|"regulates"| CR1
    APP["APP"]
    APP -->|"associated with"| CR1
    CLU["CLU"]
    CLU -->|"associated with"| CR1
    C1QA["C1QA"]
    C1QA -->|"associated with"| CR1
    CLU -->|"regulates"| CR1
    C1S["C1S"]
    C1S -->|"associated with"| CR1
    CLUSTERIN["CLUSTERIN"]
    CLUSTERIN -->|"regulates"| CR1
    C1Q["C1Q"]
    C1Q -->|"regulates"| CR1
    GENES["GENES"]
    GENES -->|"associated with"| CR1
    RS6656401["RS6656401"]
    RS6656401 -->|"associated with"| CR1
    RS3919533["RS3919533"]
    RS3919533 -->|"associated with"| CR1
    CFH["CFH"]
    CFH -->|"associated with"| CR1
    style CR1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (386)

Target	Relation	Type	Str
ad_genetic_risk_loci:CR1	data_in	dataset_row	0.00
benchmark_ot_ad_answer_key:CR1	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
ds-db4a006ea647	provides_data_for	dataset	1.00
ds-f50762b67605	provides_data_for	dataset	1.00
ABeta42	associated_with	biomarker	0.85
macrophages	expressed_in	cell_type	0.80
Cognitive Aging	risk_factor_for	phenotype	0.80
GENES	associated_with	gene	0.80
Als	associated_with	disease	0.75
Aging	associated_with	disease	0.75
Neurodegeneration	associated_with	disease	0.75
Dementia	associated_with	disease	0.75
Alzheimer	associated_with	disease	0.75
RELN	protects_against	gene	0.70
LRRK2	associated_with	gene	0.70
TREM2	markers	gene	0.70
MICROGLIA	biomarker_for	cell_type	0.70
MICROGLIA	expressed_in	cell_type	0.70
MACROPHAGE	activates	cell_type	0.70
IBA1	biomarker_for	gene	0.70
NLRP3	associated_with	gene	0.70
hippocampus	expressed_in	brain_region	0.70
ALZHEIMER	associated_with	gene	0.70
neurons	expressed_in	cell_type	0.70
complement receptor 1	encodes	protein	0.70
PICALM	associated_with	gene	0.70
APOE	associated_with	gene	0.70
Down syndrome	associated_with	disease	0.70
PSEN2	regulates	gene	0.70
COMPLEMENT	associated_with	gene	0.70
Amyloid-beta 42	regulates	protein	0.70
Complement	associated_with	pathway	0.70
stem cells	expressed_in	cell_type	0.70
ALS	associated_with	disease	0.65
CTSD	co_discussed	gene	0.65
TNF	co_discussed	gene	0.65
Multiple Sclerosis	associated_with	disease	0.65
Ms	associated_with	disease	0.65
neuroinflammation	co_discussed	disease	0.65
LRRK2	co_discussed	gene	0.65
MONOCYTES	causes	cell_type	0.65
CELL SURVIVAL	activates	phenotype	0.65
Inflammation	associated_with	disease	0.65
MAPT	co_discussed	gene	0.65
Als	interacts_with	disease	0.65
ALS	activates	disease	0.65
Aging	biomarker_for	disease	0.65
Alzheimer	biomarker_for	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65

Incoming (214)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:CR1	data_in	dataset_row	0.00
ad_genetic_risk_loci:CR1	data_in	dataset_row	0.00
ds-db4a006ea647	data_in	dataset	1.00
ds-83b31ef18d49	data_in	dataset	1.00
ds-f50762b67605	data_in	dataset	1.00
ALZHEIMER'S DISEASE	associated_with	gene	1.00
APOE	associated_with	gene	0.90
BIN1	associated_with	gene	0.82
AMYLOID	associated_with	protein	0.82
Stem Cell Therapy	modulates	drug	0.80
ALZHEIMER DISEASE	associated_with	gene	0.80
CLU	associated_with	gene	0.74
TAU	associated_with	gene	0.74
APOE	protects_against	gene	0.70
CLU	regulates	gene	0.70
rs6656401	regulates	gene	0.70
APP	associated_with	gene	0.66
TREM2	associated_with	gene	0.66
BDNF	co_discussed	gene	0.65
INFLAMMATION	activates	phenotype	0.65
INFLAMMATION	interacts_with	phenotype	0.65
MONOCYTES	treats	cell_type	0.65
BDNF	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
APOC1	associated_with	gene	0.60
CLU	activates	gene	0.60
COMPLEMENT	associated_with	gene	0.60
GMNC	associated_with	gene	0.60
COMPLEMENT	activates	gene	0.60
APOE	markers	gene	0.60
AD	activates	gene	0.60
ABCA1	associated_with	gene	0.60
ABI3	associated_with	gene	0.60
ADAM17	associated_with	gene	0.60
CD2AP	associated_with	gene	0.60
CD33	associated_with	gene	0.60
PSEN2	regulates	gene	0.60
TAU	regulates	gene	0.60
SORL1	regulates	gene	0.60
APOE4	regulates	gene	0.60
APP	regulates	gene	0.60
CD33	regulates	gene	0.60
PTK2B	interacts_with	gene	0.60
CD2AP	interacts_with	gene	0.60
TMEM106B	associated_with	gene	0.60
MS4A6A	associated_with	gene	0.60
MS4A6A	interacts_with	gene	0.60
CASS4	interacts_with	gene	0.60
CD33	activates	gene	0.60
CTSH	associated_with	gene	0.60

Targeting Hypotheses (15)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
CX3CR1-TREM2 Integration for Synapse Pruning Normalization	0.776	neurodegeneration	TREM2 agonism vs antagonism in DAM micro
TREM2-CX3CR1 Axis Dysregulation in Microglial Surveillance F	0.720	neurodegeneration	Test
CX3CR1 Promoter Methylation Disrupts Neuron-Microglia Cross-	0.649	developmental-neurobiology	Do perinatal immune challenges create pe
CX3CL1-CX3CR1 Mimetic Therapy for Neuroprotection	0.635	neurodegeneration	Microglial subtypes in neurodegeneration
CX3CR1 Agonism Enhances Microglial Phagocytosis of Extracell	0.630	neurodegeneration	Investigate prion-like spreading of tau

CX3CR1-Targeted HDAC3 Knockdown in Microglia via AAV9 Delive	0.620	pharmacology	How can CNS-selective HDAC/DNMT inhibito
CX3CR1-Negative Trem2-High Microglial Subset Mediates Female	0.570	neuroinflammation	How do regional, age, and sex-dependent
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri	0.563	neurodegeneration	Synaptic pruning by microglia in early A
Soluble CX3CL1 cleavage by ADAM proteases disengages fractal	0.540	neurodegeneration	Synaptic pruning by microglia in neurode
CX3CR1-Targeted AntimiR-155 Oligonucleotides for Microglial	0.530	pharmacology	How can CNS-selective HDAC/DNMT inhibito
GluN2B-Regulated Microglial Phagocytosis of Tau Aggregates v	0.491	neuroscience	Circuit-level neural dynamics in neurode
CX3CR1 PET with Nano-bodies for Microglial Surveillance Stat	0.477	biomarkers	What biomarkers can reliably detect micr
TREM2 Agonism with CX3CR1 Antagonism for Microglial Homeosta	0.105	neurodegeneration	Neuroinflammation Biomarker Panel for Ea
CX3CR1-Cre-Driven BMAL1 Deletion as Microglial Circadian Clo	0.000	-	Can circadian interventions selectively
CX3CR1-Targeted Regulatory T Cell Homing	0.000	-	Immune atlas neuroinflammation analysis

Mentioning Analyses (2)

Scientific analyses that reference this entity

Microglial Priming as Upstream Causal Node Across AD, PD, ALS, MS: Three-Arm Cau

neurodegeneration | 2026-04-27 | 3 hypotheses Top: 0.604

Senolytic therapy for age-related neurodegeneration

neurodegeneration | 2026-04-01 | 15 hypotheses Top: 0.822

Experiments (9)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Microglial TREM2 Agonist In Vivo Efficacy	validation	Alzheimer's Disease	0.450	0.50	mouse	proposed	$360,000
TREM2 Agonist Therapy for Parkinson's Disease — Experimental Design	validation	Parkinson's Disease	0.450	0.50	mouse	proposed	$280,000
TREM2 Function in Alzheimer's Disease — From Risk Variant to Therapeut	validation	Alzheimer's Disease	0.450	0.50	human	proposed	$2,960,000
s:** - GPR32 knockout in microglia should worsen neuroinflammation if	falsification	Neuroinflammation	0.400	0.50	cell_line	proposed	$80,000
Proposed experiment from debate on Synaptic pruning by microglia in ea	falsification	Neuroinflammation	0.400	0.50	mouse	proposed	$240,000
DLB Treatment Response Biomarkers — Predicting Cholinesterase Inhibito	clinical	Neurodegeneration	0.400	0.50	human	proposed	$6,550,000
FTD Microglia Role: Protective vs Destructive Mechanism Study	validation	Neuroinflammation	0.400	0.50	human	proposed	$2,960,000
Microglial Aging and Immune Memory in Neurodegeneration — Training the	validation	Alzheimer's Disease	0.400	0.50	human	proposed	$2,960,000
Microglial Contributions to Huntington's Disease Pathogenesis	validation	Neuroinflammation	0.400	0.50	human	proposed	$2,960,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Fractalkine Enhances Hematoma Resolution and Improves Neurological Function via [PMID:37465997]	Chen X, He X, Xu F, Xu N, Sharifi NH, Zh	Stroke	2023	1
Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Ca [PMID:35642214]	Wang M, Pan W, Xu Y, Zhang J, Wan J, Jia	J Inflamm Res	2022	1
CX3CL1/CX3CR1 signaling targets for the treatment of neurodegenerative diseases. [PMID:34492237]	Subbarayan MS, Joly-Amado A, Bickford PC	Pharmacol Ther	2022	1
Microglia in neurodegeneration. [PMID:30258234]	Hickman S, Izzy S, Sen P, Morsett L, El	Nat Neurosci	2018	1
How neuroinflammation contributes to neurodegeneration. [PMID:27540165]	Ransohoff RM	Science	2016	1
CX3CL1/CX3CR1 axis dysregulation contributes to epileptogenic mechanisms in foca [PMID:41863015]	Lei Lei; Shengyu Yang; Yinchao Li; Jiaha	Acta neuropathologica communic	2026	0
Constitutive expression of CX3CR1-BAC-Cre introduces minimal off-target effects [PMID:41924777]	Mroue-Ruiz FH, Desai B, Garvin MM, Shehu	Biochemical and biophysical re	2026	0
Systems-level molecular and immunological evidence identifies Th17/Treg modulati [PMID:41788408]	["Li X", "Li X", "Chen S", "Wang L", "Xi	Frontiers in aging neuroscienc	2026	0
Multimodal tumor thermal therapy enhances antitumor immunity by expanding tumor- [PMID:41799205]	["Wang S", "Wang Y", "Zhang Y", "Zhang Z	Theranostics	2026	0
Peripheral cancer attenuates amyloid pathology in Alzheimer's disease via cystat [PMID:41576952]	Li X, Tang X, Zeng J, Duan L, Hou Z et a	Cell	2026	0
[Corrigendum] Influence of aspirin on the CX3CL1/CX3CR1 signaling pathway in acu [PMID:41930567]	Zhang Z, Yang W, Ying R, Shi Y, Jiang H	Int J Mol Med	2026	0
CX3CR1-T280M polymorphism and end-stage renal disease development in chronic kid [PMID:41932952]	Matteo Gatti; Ivano Baragetti; Andrea Ba	Scientific reports	2026	0
SYK-dependent lipid handling in monocyte-derived macrophages governs functional [PMID:41831796]	["Zhao Y", "Hu H", "Wang J", "Hu Y", "Ya	Brain research bulletin	2026	0
Microglial Lag3 Drives α-Synuclein-induced Neurotoxic Activated (A1) Astrocytes [PMID:41542562]	["Yang X", "Kumbhar R", "Seo B", "Ha S",	bioRxiv : the preprint server	2026	0
Conserved ductular reaction mechanisms in biliary atresia and PSC derived from s [PMID:41903685]	Schofield A, Kamath BM, MacParland SA, T	Cellular and molecular gastroe	2026	0
Identification of suicide brain transcriptomic signatures using meta-analysis of [PMID:41916959]	Sokolov AV, Lafta MS, Jokinen J, Schiöth	Translational psychiatry	2026	0
Helper T cells and chemokines in elderly asthma - Mechanisms of airway inflammat [PMID:41805218]	["Wu Y"]	Biomolecules & biomedicine	2026	0
Identification of metabolism and inflammation-related biomarkers and potential d [PMID:41781900]	["Chen Y", "Zhang M", "Qiao L", "Lu F",	BMC psychiatry	2026	0
Chemokine Networks in Blood-Brain Barrier Regulation: Bidirectional Mechanisms, [PMID:41897331]	["Wu Q", "Miao Z", "Lei W", "Wu X", "Zha	Biomolecules	2026	0
Two-Sample Bidirectional Mendelian Randomization Analysis of the Causal Relation [PMID:41878553]	["Niu W", "Li J", "Jia H", "Wang L", "Xu	Clinical, cosmetic and investi	2026	0

Debates (3)

Multi-agent debates referencing this entity

Is microglial priming (TREM2/CX3CR1/complement-C1q) genuinely causally upstream

closed · Rounds: 4 · Score: 0.64 · 2026-04-28

Hypothesis debate: SASP-Mediated Complement Cascade Amplification

closed · Rounds: 4 · Score: 0.40 · 2026-04-27

Senolytics targeting p16/p21+ senescent astrocytes and microglia may reduce SASP

closed · Rounds: 4 · Score: 0.89 · 2026-04-06

Related Research

Hypotheses and analyses mentioning CR1 in their description or question text

CR1

Understanding Entity Pages

Summary

Wiki Pages (15)

CR1 Gene — Complement Component 1q Receptor

FLVCR1 — Feline Leukemia Virus Subgroup C Receptor 1

CCR1

FLVCR1 Protein

CXCR1 Gene

CR1→Complement Activation→Synaptic Pruning→AD Causal Chain

Pathway Diagram

Outgoing (386)

Incoming (214)

Targeting Hypotheses (15)

Mentioning Analyses (2)

Microglial Priming as Upstream Causal Node Across AD, PD, ALS, MS: Three-Arm Cau

Senolytic therapy for age-related neurodegeneration

Experiments (9)

Related Papers (20)

Debates (3)

Is microglial priming (TREM2/CX3CR1/complement-C1q) genuinely causally upstream

Hypothesis debate: SASP-Mediated Complement Cascade Amplification

Senolytics targeting p16/p21+ senescent astrocytes and microglia may reduce SASP

Related Research

CX3CR1-Targeted HDAC3 Knockdown in Microglia via AAV9 Delivery

CX3CR1-Negative Trem2-High Microglial Subset Mediates Female Resilience via Estr

Fractalkine Axis Amplification via CX3CR1 Positive Allosteric Modulators

Soluble CX3CL1 cleavage by ADAM proteases disengages fractalkine signaling, remo

CX3CR1-Targeted AntimiR-155 Oligonucleotides for Microglial Priming Reversal

GluN2B-Regulated Microglial Phagocytosis of Tau Aggregates via CX3CR1 Signaling

CX3CR1 PET with Nano-bodies for Microglial Surveillance State Mapping

TREM2 Agonism with CX3CR1 Antagonism for Microglial Homeostasis

CX3CR1-Cre-Driven BMAL1 Deletion as Microglial Circadian Clock Ablation

CX3CR1-Targeted Regulatory T Cell Homing

CR1

Understanding Entity Pages

Summary

Wiki Pages (15)

CR1 Gene — Complement Component 1q Receptor

FLVCR1 — Feline Leukemia Virus Subgroup C Receptor 1

CCR1

FLVCR1 Protein

CXCR1 Gene

CR1→Complement Activation→Synaptic Pruning→AD Causal Chain

CX3CR1 PET Imaging — Microglia-Targeted Neuroimaging

CX3CR1 Modulation Therapy

CX3CR1 — CX3C Chemokine Receptor 1

CX3CR1 Protein (Fractalkine Receptor)

CX3CR1-Expressing Neurons

XCR1 Neurons

CX3CR1 Modulation Therapy for Neurodegeneration

TACR1 — Tachykinin Receptor 1

CR1 Protein

Pathway Diagram

Outgoing (386)

Incoming (214)

Targeting Hypotheses (15)

Mentioning Analyses (2)

Microglial Priming as Upstream Causal Node Across AD, PD, ALS, MS: Three-Arm Cau

Senolytic therapy for age-related neurodegeneration

Experiments (9)

Related Papers (20)

Debates (3)

Is microglial priming (TREM2/CX3CR1/complement-C1q) genuinely causally upstream

Hypothesis debate: SASP-Mediated Complement Cascade Amplification

Senolytics targeting p16/p21+ senescent astrocytes and microglia may reduce SASP

Related Research

CX3CR1-Targeted HDAC3 Knockdown in Microglia via AAV9 Delivery

CX3CR1-Negative Trem2-High Microglial Subset Mediates Female Resilience via Estr

Fractalkine Axis Amplification via CX3CR1 Positive Allosteric Modulators

Soluble CX3CL1 cleavage by ADAM proteases disengages fractalkine signaling, remo

CX3CR1-Targeted AntimiR-155 Oligonucleotides for Microglial Priming Reversal

GluN2B-Regulated Microglial Phagocytosis of Tau Aggregates via CX3CR1 Signaling

CX3CR1 PET with Nano-bodies for Microglial Surveillance State Mapping

TREM2 Agonism with CX3CR1 Antagonism for Microglial Homeostasis

CX3CR1-Cre-Driven BMAL1 Deletion as Microglial Circadian Clock Ablation

CX3CR1-Targeted Regulatory T Cell Homing