Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about EMP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | EMP1 |
| Related Diseases | Hematopoietic Stem Cell Self-Renewal, Ionizing Radiation-Induced Injury |
| Related Pathways | Sphingolipid Metabolism |
Knowledge base pages for this entity
graph TD
EMP1["EMP1"]
EMP1 -.protects against.-> Hematopoietic_Stem_Cells["Hematopoietic Stem Cells"]
EMP1 -->|"inhibits"| Sphingolipid_Metabolism["Sphingolipid Metabolism"]
EMP1 -->|"suppresses"| Endoplasmic_Reticulum_Stress["Endoplasmic Reticulum Stress"]
EMP1 -->|"inhibits"| ER_STRESS["ER STRESS"]
EMP1 -->|"inhibits"| SPHINGOLIPID_METABOLISM["SPHINGOLIPID METABOLISM"]
EMP1 -->|"interacts"| CERS2["CERS2"]
EMP1 -->|"suppresses"| Dihydroceramides["Dihydroceramides"]
EMP1 -->|"regulates"| Hematopoietic_Stem_Cell_Self_R["Hematopoietic Stem Cell Self-Renewal"]
CERS2 -->|"activates"| EMP1| Target | Relation | Type | Str |
|---|---|---|---|
| Hematopoietic Stem Cells | protects_against | cell_type | 0.95 |
| Sphingolipid Metabolism | inhibits | pathway | 0.95 |
| Endoplasmic Reticulum Stress | associated_with | process | 0.95 |
| Endoplasmic Reticulum Stress | suppresses | process | 0.95 |
| ER STRESS | inhibits | entity | 0.90 |
| SPHINGOLIPID METABOLISM | inhibits | entity | 0.90 |
| CERS2 | interacts_with | entity | 0.90 |
| Dihydroceramides | suppresses | compound | 0.90 |
| Hematopoietic Stem Cell Self-Renewal | regulates | phenotype | 0.90 |
| Ionizing Radiation-Induced Injury | protects_against | phenotype | 0.90 |
| Hematopoietic Stem Cell Maintenance | involved_in | process | 0.90 |
| Hematopoietic Stem Cell Self-Renewal | involved_in | process | 0.90 |
| Endoplasmic Reticulum | expressed_in | cell_type | 0.90 |
| Hematopoietic Stem Cell Maintenance | regulates | process | 0.88 |
| Endoplasmic Reticulum Stress | inhibits | process | 0.88 |
| Long-term Maintenance of Hematopoietic Stem Cells | regulates | process | 0.85 |
| Protein Aggregates | suppresses | compound | 0.85 |
| Hematopoietic Stem Cells | associated_with | cell_type | 0.80 |
| Sphingolipid Metabolism | associated_with | pathway | 0.80 |
| hematopoietic stem cells | associated_with | cell_type | 0.80 |
| sphingolipid metabolism | associated_with | biological_process | 0.80 |
| endoplasmic reticulum stress | associated_with | biological_process | 0.80 |
| PROTEASOME | regulates | entity | 0.65 |
| LYSOSOME | regulates | entity | 0.60 |
| CERS2 | activates | gene | 0.60 |
| AND | causes | gene | 0.60 |
| Lipid Metabolism | inhibits | pathway | 0.60 |
| Er Stress | regulates | pathway | 0.60 |
| Protein Aggregation | activates | pathway | 0.60 |
| Sphingolipid | inhibits | pathway | 0.60 |
| AND | inhibits | gene | 0.60 |
| Stem Cell | inhibits | cell_type | 0.60 |
| Epithelial | regulates | cell_type | 0.60 |
| lipid metabolism | participates_in | pathway | 0.60 |
| stem cells | expressed_in | cell_type | 0.60 |
| ER stress | inhibits | process | 0.60 |
| ER stress | regulates | process | 0.60 |
| ER stress | associated_with | process | 0.60 |
| Stem Cell | expressed_in | cell_type | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||