enzyme

PROTEASOME

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PROTEASOME: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

986Connections

1Hypotheses

0Analyses

50Outgoing

12Incoming

No summary available yet. View on Wiki →

🔬 Protein Info

Gene Symbol	PROTEASOME
Associated Diseases	ALS, Aging, Als, Alzheimer, Amyotrophic Lateral Sclerosis
Interactions	TAU, SNCA, SQSTM1
KG Connections	12 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    PROTEASOME["PROTEASOME"] -->|"modulates"| HDAC6["HDAC6"]
    style HDAC6 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    PROTEASOME["PROTEASOME"] -->|"activates"| UBIQUITIN["UBIQUITIN"]
    style UBIQUITIN fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    PROTEASOME["PROTEASOME"] -->|"associated"| AUTOPHAGY["AUTOPHAGY"]
    style AUTOPHAGY fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#e0e0e0
    PROTEASOME["PROTEASOME"] -->|"activates"| NEURON["NEURON"]
    style NEURON fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    PROTEASOME["PROTEASOME"] -->|"interacts"| P62["P62"]
    style P62 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    PROTEASOME["PROTEASOME"] -->|"regulates"| BECN1["BECN1"]
    style BECN1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    PROTEASOME["PROTEASOME"] -->|"activates"| LYSOSOME["LYSOSOME"]
    style LYSOSOME fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    TAU["TAU"] -->|"interacts"| PROTEASOME["PROTEASOME"]
    style TAU fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    SNCA["SNCA"] -->|"interacts"| PROTEASOME["PROTEASOME"]
    style SNCA fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    SQSTM1["SQSTM1"] -->|"interacts"| PROTEASOME["PROTEASOME"]
    style SQSTM1 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    NRF2["NRF2"] -->|"regulates"| PROTEASOME["PROTEASOME"]
    style NRF2 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    AUTOPHAGY_1["AUTOPHAGY"] -->|"associated"| PROTEASOME["PROTEASOME"]
    style AUTOPHAGY_1 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    style PROTEASOME fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (86)

Target	Relation	Type	Str
TNF	regulates	protein	0.90
TAU	degrades	protein	0.85
TNF-α mRNA stability	regulates	phenotype	0.80
TTP	modifies	protein	0.80
Dementia	activates	disease	0.60
Als	activates	disease	0.60
Stroke	activates	disease	0.60
Als	inhibits	disease	0.60
Ischemia	inhibits	disease	0.60
Aging	degrades	disease	0.60
Ischemia	associated_with	disease	0.60
Als	interacts_with	disease	0.60
Aging	activates	disease	0.60
Cancer	activates	disease	0.60
Ferroptosis	degrades	disease	0.60
Ferroptosis	causes	disease	0.60
Neurodegeneration	causes	disease	0.60
Aging	inhibits	disease	0.60
Alzheimer	inhibits	disease	0.60
Cancer	therapeutic_target	disease	0.60
Neurodegeneration	therapeutic_target	disease	0.60
Als	expressed_in	disease	0.60
Alzheimer	regulates	disease	0.60
Als	therapeutic_target	disease	0.60
Parkinson	therapeutic_target	disease	0.60
Alzheimer	contributes_to	disease	0.60
Diabetes	regulates	disease	0.60
Atherosclerosis	regulates	disease	0.60
Parkinson	activates	disease	0.60
Aging	expressed_in	disease	0.60
Cancer	expressed_in	disease	0.60
Huntington	transports	disease	0.60
Parkinson	transports	disease	0.60
Alzheimer	transports	disease	0.60
Parkinson	associated_with	disease	0.60
Neurodegeneration	associated_with	disease	0.60
Prion Disease	regulates	disease	0.60
Parkinson	regulates	disease	0.60
Aging	interacts_with	disease	0.60
Amyotrophic Lateral Sclerosis	degrades	disease	0.60
Parkinson	degrades	disease	0.60
Neurodegeneration	degrades	disease	0.60
Alzheimer	degrades	disease	0.60
Fibrosis	therapeutic_target	disease	0.60
Als	contributes_to	disease	0.60
Blood-Brain Barrier	interacts_with	pathway	0.55
Ubiquitin-Proteasome	interacts_with	pathway	0.55
Autophagy	interacts_with	pathway	0.55
Unfolded Protein Response	interacts_with	pathway	0.55
Mtor	interacts_with	pathway	0.55

Incoming (900)

Source	Relation	Type	Str
UCH37	associated_with	enzyme	0.95
TAU	interacts_with	protein	0.85
SNCA	interacts_with	protein	0.85
SQSTM1	interacts_with	protein	0.85
SQSTM1	associated_with	entity	0.85
TAU	associated_with	entity	0.85
NRF2	regulates	entity	0.80
AUTOPHAGY	associated_with	entity	0.80
APP	involved_in	entity	0.75
TAU	involved_in	entity	0.75
EMP1	regulates	entity	0.65
P62	regulates	protein	0.64

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Early Proteasome Restoration Therapy	0.496	neurodegeneration	Gene expression changes in aging mouse b

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (2)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Unveiling the Genomic Landscape of Yan Goose (Anser cygnoides): Insights into Po [PMID:41594384]	Qi S, Ai Z, Cai Y, Zhang Y, Zhao W et al	Animals (Basel)	2026	0
NAD+ restores proteostasis through splicing-dependent autophagy. [PMID:41313318]	Ai R, Fang EF	Autophagy	2026	0

PROTEASOME

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Progressive Supranuclear Palsy (PSP)

Novel Therapy Index

Alpha-Synuclein Pathology

Alzheimer's Disease Mechanism Index

nimodipine-als

Neuroresilience Mechanisms and Evidence

NPM1 Gene

Frontotemporal Dementia (FTD) Mechanistic Pathway

neuroinflammation

CBS/PSP Treatment Rankings

NRF2 Oxidative Stress Pathway

nct07165106

GSK-3β in Neurodegeneration

HNRNPA2B1 Protein

Autophagy Mechanisms

oxidative-stress-comparison