Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about EN2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | EN2 |
| Protein Type | Transcription Factor |
| Function | Engrailed Homeobox 2 (EN2) is a member of the engrailed family of homeobox transcription factors that play critical roles in embryonic development, particularly in the central nervous system. |
| Primary Expression | the cerebellar plate and is crucial for Purkinje cell development and cerebellar foliation |
| Subcellular Localization | cytoplasm in some cell types, particularly during development |
| Amino Acids | 333 aa |
| GeneCards | EN2 |
| Human Protein Atlas | EN2 |
| Homeodomain | A 60-amino acid DNA-binding helix-turn-helix motif (positions 186-246) that recognizes and binds to specific DNA sequences (TAATTT) to regulate target gene transcription[@kissinger1990] |
| Harmonin homology domain | Involved in protein-protein interactions |
| Transactivation domain | Located at the N-terminus, responsible for activating transcription of target genes |
| Substantia nigra | High expression in dopaminergic neurons of the SNc |
| Ventral tegmental area | Expression in VTA dopaminergic neurons |
| Cerebellum | Expression in Purkinje cells and deep cerebellar nuclei |
| [Cortex](/brain-regions/cortex) | Expression in cortical layer 5 pyramidal neurons |
| Associated Diseases | neurodegeneration |
| Interactions | FOXA2, LMX1A, NURR1, PITX3, TH, EN1 |
| KG Connections | 8 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
EN2["EN2"]
FOXA2["FOXA2"]
EN2 -->|"activates"| FOXA2
LMX1A["LMX1A"]
EN2 -->|"activates"| LMX1A
NURR1["NURR1"]
EN2 -->|"activates"| NURR1
PITX3["PITX3"]
EN2 -->|"activates"| PITX3
TH["TH"]
EN2 -->|"activates"| TH
neurons(["neurons"])
EN2 -->|"expressed in"| neurons
DAT["DAT"]
DAT -->|"activates"| EN2
EN1["EN1"]
EN1 -->|"activates"| EN2
neurodegeneration["neurodegeneration"]
EN2 -->|"implicated in"| neurodegeneration
style EN2 fill:#1b5e20,stroke:#66bb6a,stroke-width:2px,color:#fffHypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-13 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||