Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NURR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
NURR1 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, associated with. Associated with Als, Inflammation, Ms. Connected to 40 entities in the SciDEX knowledge graph.
| Gene Symbol | NURR1 |
| Full Name | Nuclear Receptor Related 1 |
| Protein Type | Protein |
| Target Class | Protein |
| Function | NURR1 is an orphan nuclear receptor with ligand-independent activity: |
| Mechanism of Action | Prioritized from 1 SciDEX hypotheses, including: Programmable Neuronal Circuit Repair via Epigenetic CRISPR |
| Druggability | Low (0.50) |
| Clinical Stage | Phase I |
| Amino Acids | 598 aa |
| Exons | 8 |
| Pathways | Alpha-Synuclein, Autophagy, Er Stress, Synaptic Plasticity |
| UniProt ID | Search UniProt |
| Ensembl ID | ENSG00000153234 |
| GeneCards | NURR1 |
| Human Protein Atlas | NURR1 |
| Associated Diseases | Parkinson, Parkinson's disease, neurodegeneration |
| Known Drugs/Compounds | levodopa |
| Interactions | GFAP, LAMP1, LAMP2, GBA, CTSD, VMAT2 |
| SciDEX Target | View Target Profile |
| KG Connections | 208 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
NURR1["<b>NURR1</b>"]
Synucleinopathy{"Synucleinopathy"}
NURR1 -->|"activates"| Synucleinopathy
Inflammation{"Inflammation"}
NURR1 -->|"activates"| Inflammation
Als{"Als"}
NURR1 -->|"activates"| Als
Neuroinflammation{"Neuroinflammation"}
NURR1 -->|"activates"| Neuroinflammation
Parkinson{"Parkinson"}
NURR1 -->|"activates"| Parkinson
NURR1 -->|"regulates"| Parkinson
Ms{"Ms"}
NURR1 -->|"expressed in"| Ms
GFAP["GFAP"]
NURR1 -->|"activates"| GFAP
NEUROINFLAMMATION["NEUROINFLAMMATION"]
NURR1 -->|"activates"| NEUROINFLAMMATION
LAMP1["LAMP1"]
NURR1 -->|"activates"| LAMP1
LAMP2["LAMP2"]
NURR1 -->|"activates"| LAMP2
AUTOPHAGY["AUTOPHAGY"]
NURR1 -->|"regulates"| AUTOPHAGY
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
PARKINSON_S_DISEASE -->|"activates"| NURR1
NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
NEURODEGENERATIVE_DISEASES -->|"activates"| NURR1
PARKINSON_S_DISEASE -->|"regulates"| NURR1
LC3B["LC3B"]
LC3B -->|"activates"| NURR1
style NURR1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| DOPAMINERGIC DIFFERENTIATION | promotes | biological_process | 0.85 |
| Inflammation | activates | disease | 0.85 |
| Neuroinflammation | activates | disease | 0.85 |
| Parkinson | activates | disease | 0.85 |
| NEUROINFLAMMATION | activates | gene | 0.80 |
| ALPHA-SYNUCLEIN | activates | gene | 0.70 |
| Synucleinopathy | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Parkinson | regulates | disease | 0.65 |
| Ms | expressed_in | disease | 0.65 |
| Neurodegeneration | activates | disease | 0.65 |
| Aging | activates | disease | 0.65 |
| Parkinson | inhibits | disease | 0.65 |
| ALS | activates | disease | 0.65 |
| GFAP | activates | gene | 0.60 |
| LAMP1 | activates | gene | 0.60 |
| LAMP2 | activates | gene | 0.60 |
| GBA | inhibits | gene | 0.60 |
| CTSD | activates | gene | 0.60 |
| VMAT2 | activates | gene | 0.60 |
| MTOR | activates | gene | 0.60 |
| SNCA | regulates | gene | 0.60 |
| LRRK2 | inhibits | gene | 0.60 |
| PRKN | activates | gene | 0.60 |
| PARKIN | inhibits | gene | 0.60 |
| PARK7 | interacts_with | gene | 0.60 |
| Tubulin | expressed_in | protein | 0.60 |
| HNRNPA1 | regulates | gene | 0.60 |
| PINK1 | regulates | gene | 0.60 |
| NFM | regulates | gene | 0.60 |
| ASCL1 | activates | gene | 0.60 |
| Gdnf | activates | protein | 0.60 |
| FGFR1 | activates | gene | 0.60 |
| LMX1A | activates | gene | 0.60 |
| BDNF | activates | gene | 0.60 |
| NGF | activates | gene | 0.60 |
| UBIQUITIN | inhibits | gene | 0.60 |
| AUTOPHAGY | regulates | gene | 0.60 |
| Autophagy | regulates | pathway | 0.60 |
| NEURON | activates | gene | 0.60 |
| Mtor | activates | pathway | 0.60 |
| Autophagy | activates | pathway | 0.60 |
| Mapk | activates | pathway | 0.60 |
| INFLAMMATION | activates | gene | 0.60 |
| MICROGLIA ACTIVATION | activates | gene | 0.60 |
| MICROGLIA | activates | gene | 0.60 |
| Oxidative Stress | associated_with | pathway | 0.60 |
| AGING | activates | gene | 0.60 |
| Neurogenesis | activates | pathway | 0.60 |
| Dopaminergic | expressed_in | cell_type | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| h-9d22b570 | targets_gene | hypothesis | 0.90 |
| SDA-2026-04-02-gap-crispr-neurodegeneration-20260402 | targets | analysis | 0.80 |
| PARKINSON'S DISEASE | activates | gene | 0.70 |
| PARKINSON | activates | gene | 0.70 |
| PARKIN | activates | gene | 0.60 |
| FGFR1 | activates | gene | 0.60 |
| HNRNPA1 | regulates | gene | 0.60 |
| PARK7 | interacts_with | gene | 0.60 |
| PINK1 | regulates | gene | 0.60 |
| NFM | regulates | gene | 0.60 |
| LMX1B | associated_with | gene | 0.60 |
| NGF | activates | gene | 0.60 |
| UBIQUITIN | inhibits | gene | 0.60 |
| ASCL1 | activates | gene | 0.60 |
| GDNF | activates | gene | 0.60 |
| BDNF | activates | gene | 0.60 |
| LMX1A | activates | gene | 0.60 |
| TUBULIN | expressed_in | gene | 0.60 |
| SNCA | regulates | gene | 0.60 |
| SFPQ | interacts_with | gene | 0.60 |
| PGC1ALPHA | regulates | gene | 0.60 |
| LRRK2 | inhibits | gene | 0.60 |
| PRKN | activates | gene | 0.60 |
| PARKIN | inhibits | gene | 0.60 |
| GBA | inhibits | gene | 0.60 |
| NLRP3 | associated_with | gene | 0.60 |
| NLRP3 | co_expressed_with | gene | 0.60 |
| ATP13A2 | regulates | gene | 0.60 |
| GSK3B | regulates | gene | 0.60 |
| LRRK2 | regulates | gene | 0.60 |
| NEURODEGENERATIVE DISEASES | activates | gene | 0.60 |
| PARKINSON'S DISEASE | regulates | gene | 0.60 |
| LC3B | activates | gene | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| AMPK | activates | gene | 0.60 |
| NEUROTOXICITY | associated_with | gene | 0.60 |
| NEURODEGENERATION | activates | gene | 0.60 |
| PARKINSON'S DISEASE | associated_with | gene | 0.60 |
| OXIDATIVE STRESS | associated_with | gene | 0.60 |
| CREB | activates | gene | 0.60 |
| RNA | activates | gene | 0.60 |
| DJ-1 | interacts_with | gene | 0.60 |
| AUTOPHAGY | inhibits | gene | 0.60 |
| WNT | activates | gene | 0.60 |
| P53 | activates | gene | 0.60 |
| AGING | activates | gene | 0.60 |
| AND | expressed_in | gene | 0.60 |
| PARKINSON | regulates | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| GENES | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-03 | 14 hypotheses Top: 0.622
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||