gene

NURR1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NURR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

208Connections
0Hypotheses
1Analyses
50Outgoing
50Incoming

Summary

NURR1 is a gene implicated in neurodegeneration research. Key relationships include: activates, regulates, associated with. Associated with Als, Inflammation, Ms. Connected to 40 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolNURR1
Full NameNuclear Receptor Related 1
Protein TypeProtein
Target ClassProtein
FunctionNURR1 is an orphan nuclear receptor with ligand-independent activity:
Mechanism of ActionPrioritized from 1 SciDEX hypotheses, including: Programmable Neuronal Circuit Repair via Epigenetic CRISPR
DruggabilityLow (0.50)
Clinical StagePhase I
Amino Acids598 aa
Exons8
PathwaysAlpha-Synuclein, Autophagy, Er Stress, Synaptic Plasticity
UniProt IDSearch UniProt
Ensembl IDENSG00000153234
GeneCardsNURR1
Human Protein AtlasNURR1
Associated DiseasesParkinson, Parkinson's disease, neurodegeneration
Known Drugs/Compoundslevodopa
InteractionsGFAP, LAMP1, LAMP2, GBA, CTSD, VMAT2
SciDEX TargetView Target Profile
KG Connections208 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING
🔮 Predicted Structure: NURR1 — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

NURR1 Gene

gene · 1736 words

Therapeutics

index · 5665 words

omega-3-fatty-acids-neurodegeneration

therapeutic · 4551 words

cynata-therapeutics

company · 3643 words

SETD1B

gene · 3299 words

Nurr1 (NR4A2) Pathway in Parkinson's Disease

mechanism · 3218 words

Pathway Diagram

graph TD
    NURR1["<b>NURR1</b>"]
    Synucleinopathy{"Synucleinopathy"}
    NURR1 -->|"activates"| Synucleinopathy
    Inflammation{"Inflammation"}
    NURR1 -->|"activates"| Inflammation
    Als{"Als"}
    NURR1 -->|"activates"| Als
    Neuroinflammation{"Neuroinflammation"}
    NURR1 -->|"activates"| Neuroinflammation
    Parkinson{"Parkinson"}
    NURR1 -->|"activates"| Parkinson
    NURR1 -->|"regulates"| Parkinson
    Ms{"Ms"}
    NURR1 -->|"expressed in"| Ms
    GFAP["GFAP"]
    NURR1 -->|"activates"| GFAP
    NEUROINFLAMMATION["NEUROINFLAMMATION"]
    NURR1 -->|"activates"| NEUROINFLAMMATION
    LAMP1["LAMP1"]
    NURR1 -->|"activates"| LAMP1
    LAMP2["LAMP2"]
    NURR1 -->|"activates"| LAMP2
    AUTOPHAGY["AUTOPHAGY"]
    NURR1 -->|"regulates"| AUTOPHAGY
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"activates"| NURR1
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    NEURODEGENERATIVE_DISEASES -->|"activates"| NURR1
    PARKINSON_S_DISEASE -->|"regulates"| NURR1
    LC3B["LC3B"]
    LC3B -->|"activates"| NURR1
    style NURR1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (129)

TargetRelationTypeStr
DOPAMINERGIC DIFFERENTIATIONpromotesbiological_process0.85
Inflammationactivatesdisease0.85
Neuroinflammationactivatesdisease0.85
Parkinsonactivatesdisease0.85
NEUROINFLAMMATIONactivatesgene0.80

Incoming (79)

SourceRelationTypeStr
h-9d22b570targets_genehypothesis0.90
SDA-2026-04-02-gap-crispr-neurodegeneration-20260402targetsanalysis0.80
PARKINSON'S DISEASEactivatesgene0.70
PARKINSONactivatesgene0.70
PARKINactivatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

CRISPR-based therapeutic approaches for neurodegenerative diseases

neurodegeneration | 2026-04-03 | 14 hypotheses Top: 0.622

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found