| Gene Symbol | PSEN2 |
| Full Name | Presenilin 2 |
| Aliases | PSEN2PROTEIN |
| Chromosome | 1q42.13 |
| Protein Type | Aspartyl protease (catalytic subunit) |
| Function | Initial cleavage: APP pre-processed by BACE1 to generate C99 |
| Subcellular Localization | Endoplasmic reticulum, mitochondria, Golgi apparatus, lysosomes |
| Molecular Weight | 50 kDa |
| Amino Acids | 448 aa |
| Exons | 13 |
| Pathways | Blood-Brain Barrier, Cholesterol, Dysbiosis, Epigenetic, Gut Microbiome |
| UniProt ID | O00287 |
| NCBI Gene ID | 5664 |
| GeneCards | PSEN2 |
| Human Protein Atlas | PSEN2 |
| Associated Diseases | AD, ALS, AMI, Aging, Alzheimer |
| Known Drugs/Compounds | RAPAMYCIN, rapamycin |
| Interactions | A2M, DHCR24, HMGCR, MAPT, PARP1, PEN2 |
| KG Connections | 802 knowledge graph edges |
| Databases | GeneCardsHPASTRING |