gene

FOXA2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FOXA2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

80Connections

0Hypotheses

0Analyses

50Outgoing

27Incoming

Summary

FOXA2 is a gene implicated in neurodegeneration research. Key relationships include: associated with, expressed in, activates. Associated with Cancer, Carcinoma, Diabetes. Connected to 27 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	FOXA2
Full Name	Forkhead Box A2
Protein Type	Transcription Factor
Function	is a forkhead family transcription factor that plays critical roles in the development and maintenance of dopaminergic neurons in the midbrain.
Molecular Weight	48.3 kDa
Amino Acids	110 aa
Pathways	Angiogenesis
Ensembl ID	ENSG00000156413
GeneCards	FOXA2
Human Protein Atlas	FOXA2
Core motif	[AT]AA[AT]CAA[AT]G
FOXA2 binding sites	Found in promoters and enhancers of target genes
Pioneer factor activity	Can bind to closed chromatin and initiate gene activation
Dopamine biosynthesis	TH (tyrosine hydroxylase), DDC (DOPA decarboxylase)
Dopamine transport	DAT (SLC6A3), VMAT2 (SLC18A2)
Associated Diseases	ALS, Alzheimer, Alzheimer'S Disease, dementia, disease, neurodegeneration
Interactions	FOXO3, FOXO1, PSMA3, LMX1A, NURR1, PITX3
KG Connections	80 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    FOXA2["<b>FOXA2</b>"]
    Diabetes{"Diabetes"}
    FOXA2 -->|"expressed in"| Diabetes
    Cancer{"Cancer"}
    FOXA2 -->|"expressed in"| Cancer
    Carcinoma{"Carcinoma"}
    FOXA2 -->|"expressed in"| Carcinoma
    FOXO6["FOXO6"]
    FOXA2 -->|"associated with"| FOXO6
    FOXK2["FOXK2"]
    FOXA2 -->|"associated with"| FOXK2
    FOXO3["FOXO3"]
    FOXA2 -->|"associated with"| FOXO3
    FOXP3["FOXP3"]
    FOXA2 -->|"associated with"| FOXP3
    FOXG1["FOXG1"]
    FOXA2 -->|"associated with"| FOXG1
    FOXD3["FOXD3"]
    FOXA2 -->|"associated with"| FOXD3
    SHH["SHH"]
    FOXA2 -->|"expressed in"| SHH
    FOXN3["FOXN3"]
    FOXA2 -->|"associated with"| FOXN3
    FOXP1["FOXP1"]
    FOXA2 -->|"associated with"| FOXP1
    style FOXA2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (53)

Target	Relation	Type	Str
Diabetes	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Carcinoma	expressed_in	disease	0.65
Alzheimer	associated_with	disease	0.65
Cancer	therapeutic_target	disease	0.65
FOXO6	associated_with	gene	0.60
FOXO3	associated_with	gene	0.60
FOXP3	associated_with	gene	0.60
FOXG1	associated_with	gene	0.60
SHH	expressed_in	gene	0.60
FOXP1	associated_with	gene	0.60
FOXM1	associated_with	gene	0.60
FOXP4	associated_with	gene	0.60
FOXO4	associated_with	gene	0.60
FOXO1	associated_with	gene	0.60
FOXP2	associated_with	gene	0.60
FOXO3	activates	gene	0.60
FOXO1	activates	gene	0.60
PEN2	associated_with	gene	0.60
Rb	therapeutic_target	protein	0.60
PSMA3	interacts_with	gene	0.60
neurodegeneration	associated_with	disease	0.60
FOXK2	associated_with	gene	0.60
FOXD3	associated_with	gene	0.60
FOXN3	associated_with	gene	0.60
CANCER	expressed_in	gene	0.60
DIABETES MELLITUS	expressed_in	gene	0.60
Epigenetic	expressed_in	pathway	0.60
Hedgehog	expressed_in	pathway	0.60
INSULIN RESISTANCE	activates	gene	0.60
Lipid Metabolism	activates	pathway	0.60
Insulin Signaling	activates	pathway	0.60
AND	associated_with	gene	0.60
Angiogenesis	regulates	pathway	0.60
MYCN	regulates	gene	0.60
Epigenetic	therapeutic_target	pathway	0.60
Neuron	therapeutic_target	cell_type	0.60
P53	therapeutic_target	protein	0.60
neurons	expressed_in	cell_type	0.60
ALS	associated_with	disease	0.60
dementia	associated_with	disease	0.60
LMX1A	activates	gene	0.55
NURR1	activates	gene	0.55
PITX3	activates	gene	0.55
TH	activates	gene	0.55
epigenetic regulation	participates_in	pathway	0.55
PSMA3	co_expressed_with	protein	0.50
RBFOX1	co_expressed_with	protein	0.50
ALZHEIMER	associated_with	gene	0.50
Alzheimer'S Disease	associated_with	disease	0.50

Incoming (27)

Source	Relation	Type	Str
FOXO1	associated_with	gene	0.60
FOXP3	associated_with	gene	0.60
FOXO4	associated_with	gene	0.60
FOXP1	associated_with	gene	0.60
SHH	expressed_in	gene	0.60
FOXO3	associated_with	gene	0.60
FOXP2	associated_with	gene	0.60
APP	associated_with	gene	0.60
ANG	associated_with	gene	0.60
PTEN	therapeutic_target	gene	0.60
TP53	therapeutic_target	gene	0.60
EZH2	therapeutic_target	gene	0.60
SYP	therapeutic_target	gene	0.60
ASCL1	regulates	gene	0.60
RB1	therapeutic_target	gene	0.60
SOX2	therapeutic_target	gene	0.60
FOXD3	associated_with	gene	0.60
GENES	expressed_in	gene	0.60
FOXK2	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
AND	regulates	gene	0.60
APP/PS1	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
EN1	activates	gene	0.55
EN2	activates	gene	0.55
DAT	activates	gene	0.55
ANO3	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

FOXA2

Understanding Entity Pages

Summary

Wiki Pages (21)

FOXA2 — Forkhead Box A2

substantia-nigra

Orexin Neurons

GLI1 — GLI Family Zinc Finger 1

Nurr1 (NR4A2) Pathway in Parkinson's Disease

lmx1b

MLCS Research Methods in iPSC-Derived Dopaminergic Neurons

Validate Mitochondria-Lysosome Contact Site Dysfunction in PD

Lipid Droplet-Lysosome Axis Therapeutic Testing in Parkinson's Disease

NEUROG2 (Neurogenin-2)

Dopaminergic Substantia Nigra Neurons in Parkinson's Disease

Section 127: Advanced Cell Therapy and Transplantation in CBS/PSP

Kenai RNDP-001 Dopaminergic Progenitor Cell Therapy for Parkinson's Disease (NCT07106021)

Substantia Nigra Pars Compacta (SNc)

chd7-protein

CT1-DAP001 iPS Cell-derived Dopaminergic Progenitors for Parkinson's Disease (NCT06482268)

Substantia Nigra Pars Compacta Dopaminergic Neurons

EN2 Gene

Paranigral Nucleus (PN) Neurons