gene

PITX3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PITX3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

62Connections

0Hypotheses

2Analyses

25Outgoing

37Incoming

Summary

Page for PITX3 Gene

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🧬 Gene Info

Gene Symbol	PITX3
Full Name	Pituitary Homeobox 3
Chromosome	10q24.31
Protein Type	Transcription Factor
Target Class	Signaling Protein
Function	encodes a homeobox transcription factor critical for the development and survival of dopaminergic neurons.
Mechanism of Action	Prioritized from 1 SciDEX hypotheses, including: Programmable Neuronal Circuit Repair via Epigenetic CRISPR
Primary Expression	diencephalic dopaminergic clusters
Druggability	Low (0.10)
Clinical Stage	Phase I
Molecular Weight	~43 kDa
Amino Acids	394 aa
Pathways	insulin signaling
UniProt ID	O96038
NCBI Gene ID	5304
Ensembl ID	ENSG00000107807
OMIM	602618
GeneCards	PITX3
Human Protein Atlas	PITX3
Associated Diseases	Parkinson's disease, als, ms, neurodegeneration, parkinson
Known Drugs/Compounds	levodopa
Interactions	BCL2, NURR1, neuronal identity transcription factors, TH, RNA, NOXA
SciDEX Target	View Target Profile
KG Connections	62 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PITX3 — AlphaFold O96038 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PITX3["<b>PITX3</b>"]
    Parkinson{"Parkinson"}
    PITX3 -->|"expressed in"| Parkinson
    BCL2["BCL2"]
    PITX3 -->|"activates"| BCL2
    Apoptosis(["Apoptosis"])
    PITX3 -->|"expressed in"| Apoptosis
    neurodegeneration["neurodegeneration"]
    PITX3 -->|"implicated in"| neurodegeneration
    NOXA["NOXA"]
    NOXA -->|"activates"| PITX3
    BAX["BAX"]
    BAX -->|"expressed in"| PITX3
    style PITX3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (25)

Target	Relation	Type	Str
Parkinson	expressed_in	disease	0.65
BCL2	activates	gene	0.60
Apoptosis	expressed_in	pathway	0.60
insulin signaling	participates_in	pathway	0.55
TH	activates	gene	0.55
RNA	associated_with	gene	0.55
dopaminergic neurons	expressed_in	cell_type	0.55
neurons	expressed_in	cell_type	0.55
Parkinson's disease	associated_with	disease	0.55
stem cells	expressed_in	cell_type	0.55
RNA	interacts_with	gene	0.55
SIRT1	debate_co_mention	gene	0.45
RNA	debate_co_mention	gene	0.45
DMPK	co_discussed	gene	0.40
synaptic plasticity genes	co_discussed	gene	0.40
CREB1	co_discussed	gene	0.40
HMGCR	co_discussed	gene	0.40
mitochondrial biogenesis genes	co_discussed	gene	0.40
Disease-causing mutations with integrated reporters	co_discussed	gene	0.40
neurodegeneration	associated_with	disease	0.37
NURR1	interacts_with	gene	0.37
neuronal identity transcription factors	interacts_with	gene	0.37
ms	implicated_in	disease	0.35
parkinson	implicated_in	disease	0.35
als	implicated_in	disease	0.35

Incoming (37)

Source	Relation	Type	Str
h-9d22b570	targets_gene	hypothesis	0.90
NOXA	activates	gene	0.60
BAX	expressed_in	gene	0.60
NR4A2	regulates	gene	0.55
NURR1	regulates	gene	0.55
NURR1	associated_with	gene	0.55
NURR1	activates	gene	0.55
levodopa	targets	drug	0.55
EN1	activates	gene	0.55
EN2	activates	gene	0.55
FOXA2	activates	gene	0.55
LMX1A	activates	gene	0.55
DAT	activates	gene	0.55
BDNF	debate_co_mention	gene	0.45
Cell-type-specific essential genes	debate_co_mention	gene	0.45
FOXO3	debate_co_mention	gene	0.45
LDLR	debate_co_mention	gene	0.45
Cell-type-specific essential genes	co_discussed	gene	0.40
APOE regulatory regions	co_discussed	gene	0.40
NURR1	co_discussed	gene	0.40
FOXO3	co_discussed	gene	0.40
PGC1A	co_discussed	gene	0.40
BDNF	co_discussed	gene	0.40
LDLR	co_discussed	gene	0.40
HTT	co_discussed	gene	0.40
SIRT1	co_discussed	gene	0.40
APOE	co_discussed	gene	0.40
repeat-containing transcripts	co_discussed	gene	0.40
neuronal identity transcription factors	co_discussed	gene	0.40
DMPK	co_discussed	gene	0.40
CREB1	co_discussed	gene	0.40
synaptic plasticity genes	co_discussed	gene	0.40
HMGCR	co_discussed	gene	0.40
mitochondrial biogenesis genes	co_discussed	gene	0.40
Disease-causing mutations with integrated reporters	co_discussed	gene	0.40
NURR1	interacts_with	gene	0.37
neuronal identity transcription factors	interacts_with	gene	0.37

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Why does PGC-1α overexpression paradoxically increase MPTP toxicity despite enha

neurodegeneration | 2026-04-13 | 0 hypotheses

CRISPR-based therapeutic approaches for neurodegenerative diseases

neurodegeneration | 2026-04-03 | 14 hypotheses Top: 0.622

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PITX3

Understanding Entity Pages

Summary

Wiki Pages (21)

PITX3 Gene

Epigenetic Dysregulation in Neurodegeneration

Cellular Reprogramming Therapies for Neurodegeneration

Nurr1 (NR4A2) Pathway in Parkinson's Disease

lmx1b

PITX3 Protein

Non-coding RNAs in Neurodegeneration

APP Protein

setd1a

SMARCA2 (BRM)

APP — Amyloid Precursor Protein

FOXA2 — Forkhead Box A2

Dopaminergic VTA Neurons in Parkinson's Disease

MLCS Research Methods in iPSC-Derived Dopaminergic Neurons

Cell Type Atlas

Tyrosine Hydroxylase Th Neurons

Telencephalon Development

Dopaminergic Substantia Nigra Neurons in Parkinson's Disease

Section 144: Advanced Myelin Repair and Oligodendrocyte Therapy in CBS/PSP

SHH — Sonic Hedgehog

Section 127: Advanced Cell Therapy and Transplantation in CBS/PSP