Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about EFFEROCYTOSIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | EFFEROCYTOSIS |
| Key Genes/Proteins | CKLF1 |
Knowledge base pages for this entity
graph TD
EFFEROCYTOSIS["EFFEROCYTOSIS"]
EFFEROCYTOSIS -->|"contributes to"| Inflammation_Resolution["Inflammation Resolution"]
EFFEROCYTOSIS -->|"mediates"| Beta_Amyloid_Clearance["Beta-Amyloid Clearance"]
PIEZO1["PIEZO1"] -->|"activates"| EFFEROCYTOSIS
Macrophages["Macrophages"] -->|"involved_in"| EFFEROCYTOSIS
ANXA1["ANXA1"] -->|"promotes"| EFFEROCYTOSIS
FOXP3__macrophages["FOXP3+ macrophages"] -->|"activates"| EFFEROCYTOSIS
Loss_of_ANXA1["Loss of ANXA1"] -->|"inhibits"| EFFEROCYTOSIS
MERTK["MERTK"] -->|"mediates"| EFFEROCYTOSIS
LC3["LC3"] -->|"modulates"| EFFEROCYTOSIS| Target | Relation | Type | Str |
|---|---|---|---|
| Inflammation Resolution | contributes_to | process | 0.90 |
| inflammation resolution | promotes | process | 0.88 |
| Beta-Amyloid Clearance | mediates | process | 0.85 |
| Neutrophil Clearance | mediates | process | 0.85 |
| inflammation | inhibits | process | 0.80 |
| viral spread | inhibits | phenotype | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PIEZO1 | activates | gene | 0.95 |
| Macrophages | involved_in | cell_type | 0.95 |
| MICROGLIA | involved_in | cell_type | 0.95 |
| ANXA1 | associated_with | protein | 0.95 |
| macrophage | involved_in | cell_type | 0.92 |
| FOXP3+ macrophages | activates | cell_type | 0.92 |
| PIEZO1 | associated_with | gene | 0.90 |
| Piezo1 | activates | gene | 0.90 |
| MERTK | activates | gene | 0.90 |
| MERTK | regulates | gene | 0.90 |
| Loss of ANXA1 | inhibits | mechanism | 0.90 |
| ARG1 | involved_in | gene | 0.85 |
| MERTK | mediates | protein | 0.85 |
| ANXA1 | regulates | gene | 0.85 |
| ARG1 | regulates | gene | 0.85 |
| Reducing Microglial Lipid Load | associated_with | mechanism | 0.85 |
| Microglia | involved_in | cell_type | 0.85 |
| Tissue Stiffness | activates | property | 0.80 |
| LC3 | modulates | protein | 0.80 |
| CKLF1 | inhibits | protein | 0.64 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Microglial Efferocytosis Enhancement via GPR32 Superagonists | 0.704 | neurodegeneration | Neuroinflammation resolution mechanisms |
| C1Q-Mediated Defective Efferocytosis Driving Necrotic Core E | 0.600 | neuroinflammation | What are the specific molecular mechanis |
Scientific analyses that reference this entity
neuroinflammation | 2026-04-13 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| s:** - GPR32 knockout in microglia should worsen neuroinflammation if | falsification | Neuroinflammation | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| FTD Microglia Role: Protective vs Destructive Mechanism Study | validation | Neuroinflammation | 0.400 | 0.50 | human | proposed | $2,960,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| PAD4 promotes macrophage migration to aggravate tubulointerstitial injury in dia [PMID:41054305] | Xiong Y, Li R, Chen X, Peng C, Zeng Q, Z | Mol Ther | 2026 | 1 |
| Chemerin-CMKLR1 differentially mediated OGD/R-induced mitochondrial dysfunction, [PMID:41151300] | Long PY, Tang Z, Cai N, Yan ZQ, Gao X, W | Biomed Pharmacother | 2025 | 1 |
| The chemerin-CMKLR1 axis limits thermogenesis by controlling a beige adipocyte/I [PMID:34330814] | Lin Y, Xiao L, Cai Q, Zhu C, Li S, Li B, | Sci Immunol | 2021 | 1 |
| Microglial Aβ receptors in Alzheimer's disease. [PMID:25149075] | Yu Y, Ye RD | Cell Mol Neurobiol | 2015 | 1 |
| Molecular Signaling and Biased Agonism of the CHEMR23 Receptor: Implications for [PMID:41486998] | ["Neprelyuk O", "Romanenko I", "Irza O", | Current protein & peptide scie | 2026 | 0 |
| Receptor-Mediated Shuttling of a D-Amino Acid Peptide Achieves High Nanomolar Cy [PMID:41422545] | ["List M", "Beck-Sickinger A"] | Journal of the American Chemic | 2026 | 0 |
| Follicle-dependent differential localization of adipokines in the letrozole-indu [PMID:41857436] | ["Dutta A", "Gurusubramanian G", "Roy V" | Histochemistry and cell biolog | 2026 | 0 |
| Targeting the CMKLR1-Mediated Signaling Rebalances Immunometabolism State in Mid [PMID:41538650] | ["Zhu Z", "Du F", "Liu Y", "Yang J", "Ge | Advanced science (Weinheim, Ba | 2026 | 0 |
| Biomarkers of haemodynamic severity of systemic sclerosis-associated pulmonary a [PMID:36600187] | ["Sanges S", "Rice L", "Tu L", "Valenzi | Annals of the rheumatic diseas | 2023 | 0 |
| The Chemerin/CMKLR1 Axis Is Involved in the Recruitment of Microglia to Aβ Depos [PMID:36012305] | Chen Y, Liu Z, Gong P, Zhang H, Chen Y, | International journal of molec | 2022 | 0 |
| Chemerin partly mediates tumor-inhibitory effect of all-trans retinoic acid via [PMID:31063220] | Song Y, Yin W, Dan Y, Sheng J, Zeng Y, H | Immunology | 2019 | 0 |
| Chemerin/ChemR23 axis promotes inflammation of glomerular endothelial cells in d [PMID:30784180] | ["Shang J", "Wang L", "Zhang Y", "Zhang | Journal of cellular and molecu | 2019 | 0 |
| Targeting the D Series Resolvin Receptor System for the Treatment of Osteoarthri [PMID:27860453] | ["Huang J", "Burston J", "Li L", "Ashraf | Arthritis & rheumatology (Hobo | 2017 | 0 |
| Vitamin D and the omega-3 fatty acids control serotonin synthesis and action, pa [PMID:25713056] | ["Patrick R", "Ames B"] | FASEB journal : official publi | 2015 | 0 |
| The chemerin receptor CMKLR1 is a functional receptor for amyloid-β peptide. [PMID:25079809] | Peng L, Yu Y, Liu J, Li S, He H, Cheng N | Journal of Alzheimer's disease | 2015 | 0 |
| Intestinal inhibition of the Na+/H+ exchanger 3 prevents cardiorenal damage in r [PMID:24622516] | ["Spencer A", "Labonte E", "Rosenbaum D" | Science translational medicine | 2014 | 0 |
| Overexpression of Ras homologous C (RhoC) induces malignant transformation of he [PMID:23382905] | ["Xie S", "Zhu M", "Lv G", "Geng Y", "Ch | PloS one | 2013 | 0 |
| International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coup [PMID:23686350] | ["Davenport A", "Alexander S", "Sharman | Pharmacological reviews | 2013 | 0 |
| Resolvins: natural agonists for resolution of pulmonary inflammation. [PMID:20887750] | Uddin M, Levy BD | Progress in lipid research | 2011 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning EFFEROCYTOSIS in their description or question text
No additional research found