protein

GBAPROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GBAPROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Beyond its enzymatic function, GBA plays crucial roles in autophagy, alpha-synuclein metabolism, and lysosomal homeostasis [@mazzulli2011].

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🔬 Protein Info

Gene Symbol	GBAPROTEIN
Full Name	Glucocerebrosidase (GCase)
Protein Type	Protein
Function	is a lysosomal enzyme encoded by the GBA gene that catalyzes the hydrolysis of glucosylceramide to glucose and ceramide [@brumshtein2006].
UniProt ID	Search UniProt
GeneCards	GBAPROTEIN
Human Protein Atlas	GBAPROTEIN
Signal peptide	Directs secretion and lysosomal targeting [@jonsson1987]
Catalytic domain	Beta-glucosidase active site [@dvir2003]
Three N-linked glycosylation sites	Required for proper folding and trafficking [@bergmann1989]
Carbohydrate recognition domain	Binds glucosylceramide substrate [@terlecky1995]
Substrate	Glucosylceramide (GlcCer) → Glucose + Ceramide [@lehman1969]
Optimal pH	pH 4.5-5.0 (lysosomal environment) [@aerts1986]
Cofactors	Requires water and optimal pH [@grabowski1990]
Deficiency	Causes GlcCer accumulation in Gaucher disease [@beutler2001]
Associated Diseases	AD, Aging, ALI, Als, Alzheimer
Known Drugs/Compounds	AAV.GMU01_SS3-GBA1, glucosylceramide, NCGC00188758
Interactions	ABCD3, ACHE, Actin, AD, AGING, ALPHA-SYNUCLEIN
SciDEX Hypotheses	Glucosylceramide accumulation nucleates alpha-synu Freezing-of-Gait Prediction Algorithm Using GBA Mu Adaptive Deep Brain Stimulation Targeting the Pedu (+2 more)
KG Connections	1591 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: GBAPROTEIN — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Glucocerebrosidase (GCase)

protein · 2125 words

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Pathway Diagram

graph TD
    GBAPROTEIN["GBAPROTEIN"]
    neurodegeneration["neurodegeneration"]
    GBAPROTEIN -->|"implicated_in"| neurodegeneration
    style GBAPROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning GBAPROTEIN in their description or question text

No additional research found