gene

GSTM1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GSTM1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

12Connections

0Hypotheses

0Analyses

5Outgoing

7Incoming

0Experiments

0Debates

Summary

GSTM1 is a gene implicated in neurodegeneration research. Key relationships include: regulates, inhibits, implicated in. Associated with Cancer, Carcinoma, Tumor. Connected to 13 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	GSTM1
Full Name	Glutathione S-Transferase Mu 1
Chromosome	1p13.3
Protein Type	Enzyme
Function	GSTM1 (Glutathione S-Transferase Mu 1) encodes a member of the glutathione S-transferase (GST) family of enzymes that catalyze the conjugation of glutathione (GSH) to a wide variety of endogenous and
Subcellular Localization	** \| Cytoplasm (predominant), mitochondria \|
Molecular Weight	26 kDa
Amino Acids	218 aa
Pathways	Notch, Telomere
UniProt ID	[P09488](https://www.uniprot.org/uniprot/P09488)
Ensembl ID	ENSG00000166736
GeneCards	GSTM1
Human Protein Atlas	GSTM1
N-Terminal Domain (G-site, aa 1-80)	Contains the glutathione (GSH) binding site that recognizes and binds the tripeptide GSH with high affinity. Key residues include Tyr6 and Gln67 that form hydrogen bonds with GSH.
C-Terminal Domain (H-site, aa 90-218)	The hydrophobic substrate binding site that accommodates a wide range of electrophilic substrates. This domain determines the substrate specificity of GSTM1.
Associated Diseases	neurodegeneration
Interactions	APC, GENES, MYC, P53, RAS
KG Connections	12 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

GSTM1 Protein (Glutathione S-Transferase Mu 1)

protein · 1710 words

→

GSTM1 (Glutathione S-Transferase Mu 1)

gene · 621 words

→

Pathway Diagram

graph TD
    GSTM1["GSTM1"]
    Tumor{"Tumor"}
    GSTM1 -.->|"inhibits"| Tumor
    Cancer{"Cancer"}
    GSTM1 -->|"regulates"| Cancer
    Carcinoma{"Carcinoma"}
    GSTM1 -->|"regulates"| Carcinoma
    Telomere["Telomere"]
    GSTM1 -->|"regulates"| Telomere
    Notch["Notch"]
    GSTM1 -->|"regulates"| Notch
    neurodegeneration["neurodegeneration"]
    GSTM1 -->|"implicated_in"| neurodegeneration
    P53(["P53"])
    P53 -.->|"inhibits"| GSTM1
    RAS(["RAS"])
    RAS -.->|"inhibits"| GSTM1
    APC(["APC"])
    APC -.->|"inhibits"| GSTM1
    CANCER(["CANCER"])
    CANCER -->|"regulates"| GSTM1
    style GSTM1 fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (5)

Target	Relation	Type	Str
Tumor	inhibits	disease	0.65
Cancer	regulates	disease	0.65
Carcinoma	regulates	disease	0.65
Telomere	regulates	pathway	0.60
Notch	regulates	pathway	0.60

Incoming (7)

Source	Relation	Type	Str
P53	inhibits	gene	0.60
RAS	inhibits	gene	0.60
CANCER	regulates	gene	0.60
GENES	inhibits	gene	0.60
DNA	regulates	gene	0.60
APC	inhibits	gene	0.60
MYC	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GSTM1 in their description or question text

No additional research found