pathway

Telomere

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Telomere: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

218Connections

0Hypotheses

0Analyses

14Outgoing

50Incoming

No summary available yet. View on Wiki →

🔀 Pathway Info

Name	Telomere
Key Genes/Proteins	AGING, MITOCHONDRIAL DYSFUNCTION, INFLAMMATION, CANCER, DNA
Related Diseases	Aging, Senescence, Als, Cardiovascular, Cancer

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    AGING["AGING"] -->|"associated"| Telomere["Telomere"]
    MITOCHONDRIAL_DYSFUNCTION["MITOCHONDRIAL DYSFUNCTION"] -->|"associated"| Telomere["Telomere"]
    Aging["Aging"] -->|"associated"| Telomere["Telomere"]
    Senescence["Senescence"] -->|"associated"| Telomere["Telomere"]
    style Telomere fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (14)

Target	Relation	Type	Str
COPD	activates	disease	0.50
ENDOTHELIAL CELLS	activates	concept	0.50
COPD	inhibits	disease	0.50
MONOCYTE	activates	concept	0.50
COPD	associated_with	disease	0.50
Proteostasis	interacts_with	process	0.50
Cellular Senescence	interacts_with	cell_type	0.50
IPSC	activates	concept	0.50
Proteostasis	associated_with	process	0.50
Proteostasis	regulates	process	0.50
Cellular Senescence	regulates	cell_type	0.50
Cellular Senescence	activates	cell_type	0.50
Reactive Oxygen Species	activates	process	0.50
CHRONIC INFLAMMATION	regulates	concept	0.50

Incoming (204)

Source	Relation	Type	Str
AGING	associated_with	gene	1.00
MITOCHONDRIAL DYSFUNCTION	associated_with	gene	1.00
Aging	associated_with	disease	1.00
Senescence	associated_with	disease	1.00
Als	associated_with	disease	1.00
Cardiovascular	associated_with	disease	1.00
Cancer	associated_with	disease	1.00
INFLAMMATION	associated_with	gene	0.90
Inflammation	associated_with	disease	0.90
CANCER	associated_with	gene	0.90
CANCER	regulates	gene	0.80
DNA	regulates	gene	0.80
Cancer	regulates	disease	0.80
AGING	regulates	gene	0.80
Aging	regulates	disease	0.80
Senescence	regulates	disease	0.80
ALZHEIMER	associated_with	gene	0.80
NEURODEGENERATIVE DISEASES	associated_with	gene	0.80
Alzheimer	associated_with	disease	0.80
GENES	associated_with	gene	0.80
Tumor	regulates	disease	0.70
AGING	inhibits	gene	0.70
Aging	inhibits	disease	0.70
MITOCHONDRIA	regulates	gene	0.70
CANCER	activates	gene	0.70
Cancer	activates	disease	0.70
Als	implicated_in	disease	0.70
Senescence	implicated_in	disease	0.70
OXIDATIVE STRESS	associated_with	gene	0.70
APOPTOSIS	activates	gene	0.70
AKT	activates	gene	0.70
Tumor	activates	disease	0.70
PARKINSON	associated_with	gene	0.70
Parkinson	associated_with	disease	0.70
Als	activates	disease	0.70
ALZHEIMER DISEASE	associated_with	gene	0.70
Cardiovascular	therapeutic_target	disease	0.70
Diabetes	associated_with	disease	0.70
AUTOPHAGY	associated_with	gene	0.70
CANCER	expressed_in	gene	0.60
Breast Cancer	expressed_in	disease	0.60
Cancer	expressed_in	disease	0.60
Carcinoma	expressed_in	disease	0.60
P53	regulates	gene	0.60
RAS	regulates	gene	0.60
APC	regulates	gene	0.60
GENES	regulates	gene	0.60
MYC	regulates	gene	0.60
GSTM1	regulates	gene	0.60
Carcinoma	regulates	disease	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Telomere

Understanding Entity Pages

Wiki Pages (20)

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Parthanatos in Neurodegeneration

calcium-dysregulation-comparison

Alzheimer's Disease Mechanism Index

Microglial Cells — Cell Type Hierarchy

HNRNPA2B1 Protein

Oligodendrocytes

rankings

Microglial Senescence Pathway in Neurodegeneration

DNA Damage Response Impairment Pathway

Cellular Senescence in Neurodegeneration

KRIT1 — Krev Interaction Trapped 1 (CCM1)

DDB2 Gene

Longevity and Rejuvenation Therapies Landscape

Blood-Brain Barrier Breakdown in Neurodegeneration

alpha-lipoic-acid-neurodegeneration

DNA Damage Response in Alzheimer's Disease