Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HISTONE ACETYLATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
graph TD
HISTONE_ACETYLATION["HISTONE ACETYLATION"]
HISTONE_ACETYLATION -->|"activates"| memory_consolidation["memory consolidation"]
HISTONE_ACETYLATION -->|"involved_in"| Chromatin_Remodeling["Chromatin Remodeling"]
HISTONE_ACETYLATION -->|"inhibits"| Histone_Lactylation["Histone Lactylation"]
HISTONE_ACETYLATION -->|"upstream_of"| PDCD1LG1["PDCD1LG1"]
HISTONE_ACETYLATION -->|"involved_in"| Alzheimer_s_Disease["Alzheimer's Disease"]
HISTONE_ACETYLATION -->|"regulates"| synaptic_plasticity["synaptic plasticity"]
HDAC["HDAC"] -->|"regulates"| HISTONE_ACETYLATION
APOE["APOE"] -->|"activates"| HISTONE_ACETYLATION
EP300["EP300"] -->|"regulates"| HISTONE_ACETYLATION
HDAC_Inhibitors["HDAC Inhibitors"] -->|"modulates"| HISTONE_ACETYLATION
acetate["acetate"] -->|"promotes"| HISTONE_ACETYLATION
YAP["YAP"] -->|"modulates"| HISTONE_ACETYLATION
HDAC_Inhibition["HDAC Inhibition"] -->|"upregulates"| HISTONE_ACETYLATION| Target | Relation | Type | Str |
|---|---|---|---|
| NEURONS | activates | cell_type | 0.65 |
| NEURON | implicated_in | cell_type | 0.55 |
| NICOTINAMIDE | associated_with | drug | 0.50 |
| RAPAMYCIN | associated_with | drug | 0.45 |
| FRONTAL CORTEX | associated_with | brain_region | 0.45 |
| HIPPOCAMPUS | associated_with | brain_region | 0.45 |
| CORTEX | associated_with | brain_region | 0.45 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||