concept

HISTONE ACETYLATION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HISTONE ACETYLATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

38Connections

0Hypotheses

2Analyses

15Outgoing

23Incoming

0Experiments

2Debates

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💡 Concept Info

Name	HISTONE ACETYLATION
Key Genes/Proteins	APOE, ERK, HK2, SIRT6
Related Diseases	CSF

Pathway Diagram

graph TD
    HISTONE_ACETYLATION["HISTONE ACETYLATION"]
    HISTONE_ACETYLATION -->|"activates"| memory_consolidation["memory consolidation"]
    HISTONE_ACETYLATION -->|"involved_in"| Chromatin_Remodeling["Chromatin Remodeling"]
    HISTONE_ACETYLATION -->|"inhibits"| Histone_Lactylation["Histone Lactylation"]
    HISTONE_ACETYLATION -->|"upstream_of"| PDCD1LG1["PDCD1LG1"]
    HISTONE_ACETYLATION -->|"involved_in"| Alzheimer_s_Disease["Alzheimer's Disease"]
    HISTONE_ACETYLATION -->|"regulates"| synaptic_plasticity["synaptic plasticity"]
    HDAC["HDAC"] -->|"regulates"| HISTONE_ACETYLATION
    APOE["APOE"] -->|"activates"| HISTONE_ACETYLATION
    EP300["EP300"] -->|"regulates"| HISTONE_ACETYLATION
    HDAC_Inhibitors["HDAC Inhibitors"] -->|"modulates"| HISTONE_ACETYLATION
    acetate["acetate"] -->|"promotes"| HISTONE_ACETYLATION
    YAP["YAP"] -->|"modulates"| HISTONE_ACETYLATION
    HDAC_Inhibition["HDAC Inhibition"] -->|"upregulates"| HISTONE_ACETYLATION

Outgoing (15)

Target	Relation	Type	Str
memory consolidation	activates	phenotype	0.90
neurobehavioral changes in neurodegenerative disorders	associated_with	phenotype	0.90
Chromatin Remodeling	involved_in	process	0.90
Histone Lactylation	inhibits	mechanism	0.85
Histone Lactylation	modulates	mechanism	0.85
PDCD1LG1	upstream_of	gene	0.85
Alzheimer's Disease	involved_in	disease	0.80
synaptic plasticity	regulates	process	0.70
NEURONS	activates	cell_type	0.65
NEURON	implicated_in	cell_type	0.55
NICOTINAMIDE	associated_with	drug	0.50
RAPAMYCIN	associated_with	drug	0.45
FRONTAL CORTEX	associated_with	brain_region	0.45
HIPPOCAMPUS	associated_with	brain_region	0.45
CORTEX	associated_with	brain_region	0.45

Incoming (23)

Source	Relation	Type	Str
HDAC Inhibitors	modulates	drug	0.90
HDAC3	suppresses	gene	0.90
HDAC8	suppresses	gene	0.90
KAT2A	associated_with	gene	0.90
KAT2A	catalyzes	gene	0.90
acetyl-CoA	modulates	metabolite	0.90
APOE	activates	gene	0.90
EP300	regulates	protein	0.90
KAT2A	regulates	gene	0.90
acetyl-CoA	regulates	protein	0.90
acetate	promotes	protein	0.89
YAP	modulates	protein	0.87
HDAC Inhibition	upregulates	mechanism	0.85
acetyl-CoA	activates	protein	0.80
amyloid-beta 1-42	upregulates	compound	0.80
coenzyme A	regulates	process	0.70
APOE	regulates	gene	0.65
HK2	activates	gene	0.65
SIRT6	regulates	gene	0.60
ERK	regulates	gene	0.60
ASTROCYTE	inhibits	cell_type	0.60
CSF	inhibits	phenotype	0.60
HK2	implicated_in	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Do different priming stimuli require distinct therapeutic approaches or share co

immunology | 2026-04-08 | 8 hypotheses Top: 0.380

Epigenetic reprogramming in aging neurons

neurodegeneration | 2026-04-02 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

Do different priming stimuli require distinct therapeutic approaches or share co

closed · Rounds: 4 · Score: 0.93 · 2026-04-10

Epigenetic reprogramming in aging neurons

closed · Rounds: 4 · Score: 0.95 · 2026-04-02

Related Research

Hypotheses and analyses mentioning HISTONE ACETYLATION in their description or question text

No additional research found