gene

KAT2A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KAT2A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

212Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

KAT2A is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, regulates. Associated with Als, Breast Cancer, Cancer. Connected to 108 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	KAT2A
Full Name	Lysine Acetyltransferase 2A
Chromosome	17q21.2
Protein Type	Transferase
Function	encodes a histone acetyltransferase that catalyzes the acetylation of histone H3 at lysines 9, 14, 18, and 36 (H3K9ac, H3K14ac, H3K18ac, H3K36ac).
Amino Acids	837 aa
Pathways	Chaperone, Invasion, Metastasis, Tgf-Β, Tgf-Β Signaling
UniProt ID	[Q92830](https://www.uniprot.org/uniprot/Q92830)
Ensembl ID	ENSG00000108773
GeneCards	KAT2A
Human Protein Atlas	KAT2A
HAT domain	Catalytic acetyltransferase domain that transfers acetyl groups from acetyl-CoA to histone lysine residues
Bromodomain	Chromatin reader module that recognizes pre-existing acetylated histones, particularly H4K16ac, enabling positive-feedback acetylation spreading
ADA2-interaction domain	Mediates incorporation into the SAGA (Spt-Ada-Gcn5-Acetyltransferase) and ATAC (Ada Two A-Containing) multi-subunit complexes
ATAC complex	Contains KAT2A and the histone acetyltransferase ATAC2. ATAC specifically acetylates H3K14 and H4K5/12 at enhancers and is involved in mitotic chromosome condensation.
Associated Diseases	histone acetylation, Parkinson, Tumor
Known Drugs/Compounds	rapamycin
Interactions	ACAT1, AMPK, ATG, CALCOCO2, CANCER, CBP
KG Connections	212 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

KAT2A (Lysine Acetyltransferase 2A)

gene · 1316 words

→

Pathway Diagram

graph TD
    KAT2A["KAT2A"]
    KAT2A -->|"activates"| Als["Als"]
    KAT2A -->|"activates"| Cancer["Cancer"]
    KAT2A -->|"activates"| Tumor["Tumor"]
    KAT2A -->|"activates"| YAP["YAP"]
    KAT2A -->|"activates"| Tgf__["Tgf-Beta"]
    KAT2A -->|"implicated in"| neurodegeneration["neurodegeneration"]
    HIPPO["HIPPO"] -->|"activates"| KAT2A
    MYC["MYC"] -->|"interacts"| KAT2A
    CANCER["CANCER"] -->|"activates"| KAT2A
    MARK4["MARK4"] -->|"activates"| KAT2A
    LYSOSOME["LYSOSOME"] -->|"regulates"| KAT2A

Outgoing (130)

Target	Relation	Type	Str
histone acetylation	regulates	phenotype	0.90
histone acetylation	catalyzes	epigenetic_modification	0.90
histone acetylation	associated_with	phenotype	0.90
Tumor	activates	disease	0.65
Als	activates	disease	0.65
Cancer	activates	disease	0.65
Tumor	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Breast Cancer	activates	disease	0.65
FIP200	associated_with	gene	0.60
RUBCN	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
KAT2B	associated_with	gene	0.60
HSP70	associated_with	gene	0.60
SIRT1	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
STX17	associated_with	gene	0.60
CALCOCO2	associated_with	gene	0.60
VAMP8	associated_with	gene	0.60
CREBBP	associated_with	gene	0.60
LC3	associated_with	gene	0.60
NBR1	associated_with	gene	0.60
PLK4	regulates	gene	0.60
PLK4	associated_with	gene	0.60
PLK4	phosphorylates	gene	0.60
PLK4	protects_against	gene	0.60
Mtor	associated_with	pathway	0.60
Apoptosis	associated_with	pathway	0.60
Autophagy	associated_with	pathway	0.60
ACETYL-COA	associated_with	gene	0.60
APOPTOSIS	associated_with	gene	0.60
AMPK	associated_with	gene	0.60
MAP1LC3	associated_with	gene	0.60
CREB	associated_with	gene	0.60
P53	associated_with	gene	0.60
ACAT1	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
ATG	associated_with	gene	0.60
LYSOSOME	regulates	gene	0.60
CANCER	activates	gene	0.60
Metastasis	activates	pathway	0.60
Invasion	activates	pathway	0.60
TP53	associated_with	gene	0.60
Tgf-Β Signaling	activates	pathway	0.60
HDAC6	associated_with	gene	0.60
HSPA8	associated_with	gene	0.60
SNAP29	associated_with	gene	0.60
PIK3C3	associated_with	gene	0.60

Incoming (82)

Source	Relation	Type	Str
C-MYC	interacts_with	gene	0.60
ULK1	associated_with	gene	0.60
CALCOCO2	associated_with	gene	0.60
HSPA8	associated_with	gene	0.60
STX17	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
KAT8	associated_with	gene	0.60
RB1CC1	associated_with	gene	0.60
SIRT1	associated_with	gene	0.60
LC3	associated_with	gene	0.60
SNAP29	associated_with	gene	0.60
RB1	associated_with	gene	0.60
KAT2B	associated_with	gene	0.60
KAT5	associated_with	gene	0.60
WIPI2	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
HDAC6	associated_with	gene	0.60
CREBBP	associated_with	gene	0.60
NBR1	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
HSP70	associated_with	gene	0.60
NDP52	associated_with	gene	0.60
VAMP8	associated_with	gene	0.60
EP300	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
PIK3C3	associated_with	gene	0.60
LAMP2A	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
P62	associated_with	gene	0.60
TP53	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
OPTN	associated_with	gene	0.60
AMPK	associated_with	gene	0.60
MAP1LC3	associated_with	gene	0.60
APOPTOSIS	associated_with	gene	0.60
CREB	associated_with	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
CBP	activates	gene	0.60
HSC70	activates	gene	0.60
BECN1	activates	entity	0.60
CALCOCO2	activates	entity	0.60
CREBBP	activates	entity	0.60
EP300	activates	entity	0.60
FIP200	activates	entity	0.60
GAPDH	activates	entity	0.60
HDAC6	activates	entity	0.60
HSP70	activates	entity	0.60
HSPA8	activates	entity	0.60
OPTINEURIN	associated_with	gene	0.60
FIP200	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Do different priming stimuli require distinct therapeutic approaches or share co

immunology | 2026-04-08 | 8 hypotheses Top: 0.380

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Do different priming stimuli require distinct therapeutic approaches or share co

closed · Rounds: 4 · Score: 0.93 · 2026-04-10

Related Research

Hypotheses and analyses mentioning KAT2A in their description or question text

No additional research found