gene

HRH1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HRH1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

13Connections
0Hypotheses
0Analyses
6Outgoing
7Incoming

Summary

HRH1 is a gene implicated in neurodegeneration research. Key relationships include: activates, implicated in. Associated with Als, Ms. Connected to 14 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolHRH1
Full NameHistamine Receptor H1
Chromosome3p25
FunctionHRH1 encodes the H1 histamine receptor.
Primary Expressionthe brain and play roles in cognitive function, attention, and motor control
PathwaysDna Methylation, Epigenetic
UniProt ID[P35367](https://www.uniprot.org/uniprotkb/P35367/entry)
GeneCardsHRH1
Human Protein AtlasHRH1
Associated DiseasesAllergies, cognitive function
InteractionsGRIN1, HCRTR1, DRD2, HRH3, HCRTR2, ADRA1B
KG Connections13 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (13)

Knowledge base pages for this entity

Canonical Page

HRH1 Gene

gene · 618 words

Histamine

entity · 4009 words

GRIN1 — NMDA Receptor Subunit 1

gene · 2946 words

ADRA1B — Alpha-1B Adrenergic Receptor

gene · 1547 words

Tuberomammillary Nucleus Histaminergic Neurons

cell · 1254 words

ADRA1A Gene

gene · 1073 words

Pathway Diagram

graph TD
    HRH1["<b>HRH1</b>"]
    Ms{"Ms"}
    HRH1 -->|"activates"| Ms
    Als{"Als"}
    HRH1 -->|"activates"| Als
    GRIN1["GRIN1"]
    HRH1 -->|"activates"| GRIN1
    HCRTR1["HCRTR1"]
    HRH1 -->|"activates"| HCRTR1
    Epigenetic(["Epigenetic"])
    HRH1 -->|"activates"| Epigenetic
    Dna_Methylation(["Dna Methylation"])
    HRH1 -->|"activates"| Dna_Methylation
    neurodegeneration["neurodegeneration"]
    HRH1 -->|"implicated in"| neurodegeneration
    DRD2["DRD2"]
    DRD2 -->|"activates"| HRH1
    HRH3["HRH3"]
    HRH3 -->|"activates"| HRH1
    HCRTR2["HCRTR2"]
    HCRTR2 -->|"activates"| HRH1
    ADRA1B["ADRA1B"]
    ADRA1B -->|"activates"| HRH1
    DRD1["DRD1"]
    DRD1 -->|"activates"| HRH1
    GRIA1["GRIA1"]
    GRIA1 -->|"activates"| HRH1
    ADRA1A["ADRA1A"]
    ADRA1A -->|"activates"| HRH1
    style HRH1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (6)

TargetRelationTypeStr
Msactivatesdisease0.65
Alsactivatesdisease0.65
GRIN1activatesgene0.60
HCRTR1activatesgene0.60
Epigeneticactivatespathway0.60

Incoming (7)

SourceRelationTypeStr
DRD2activatesgene0.60
HRH3activatesgene0.60
HCRTR2activatesgene0.60
ADRA1Bactivatesgene0.60
DRD1activatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found