Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HRH3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
HRH3 is a gene implicated in neurodegeneration research. Key relationships include: activates, implicated in. Associated with Als, Ms. Connected to 14 entities in the SciDEX knowledge graph.
| Gene Symbol | HRH3 |
| Full Name | Histamine Receptor H3 |
| Chromosome | 20q13.33 |
| Function | HRH3 encodes the H3 histamine receptor. |
| Primary Expression | the brain and play roles in cognitive function, attention, and motor control |
| Pathways | Dna Methylation, Epigenetic |
| UniProt ID | [Q9Y5N1](https://www.uniprot.org/uniprotkb/Q9Y5N1/entry) |
| NCBI Gene ID | 11255 |
| Ensembl ID | ENSG00000101180 |
| OMIM | 607340 |
| GeneCards | HRH3 |
| Human Protein Atlas | HRH3 |
| Associated Diseases | Narcolepsy, cognition, addiction |
| Interactions | HCRTR2, ADRA1B, DRD1, GRIA1, ADRA1A, HRH1 |
| KG Connections | 13 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
HRH3["<b>HRH3</b>"]
Ms{"Ms"}
HRH3 -->|"activates"| Ms
Als{"Als"}
HRH3 -->|"activates"| Als
HCRTR2["HCRTR2"]
HRH3 -->|"activates"| HCRTR2
ADRA1B["ADRA1B"]
HRH3 -->|"activates"| ADRA1B
DRD1["DRD1"]
HRH3 -->|"activates"| DRD1
GRIA1["GRIA1"]
HRH3 -->|"activates"| GRIA1
ADRA1A["ADRA1A"]
HRH3 -->|"activates"| ADRA1A
HRH1["HRH1"]
HRH3 -->|"activates"| HRH1
GRIN1["GRIN1"]
HRH3 -->|"activates"| GRIN1
HCRTR1["HCRTR1"]
HRH3 -->|"activates"| HCRTR1
Epigenetic(["Epigenetic"])
HRH3 -->|"activates"| Epigenetic
Dna_Methylation(["Dna Methylation"])
HRH3 -->|"activates"| Dna_Methylation
DRD2["DRD2"]
DRD2 -->|"activates"| HRH3
style HRH3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Ms | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| HCRTR2 | activates | gene | 0.60 |
| ADRA1B | activates | gene | 0.60 |
| DRD1 | activates | gene | 0.60 |
| GRIA1 | activates | gene | 0.60 |
| ADRA1A | activates | gene | 0.60 |
| HRH1 | activates | gene | 0.60 |
| GRIN1 | activates | gene | 0.60 |
| HCRTR1 | activates | gene | 0.60 |
| Epigenetic | activates | pathway | 0.60 |
| Dna Methylation | activates | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| DRD2 | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||