gene

HRH3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HRH3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

13Connections
0Hypotheses
0Analyses
12Outgoing
1Incoming

Summary

HRH3 is a gene implicated in neurodegeneration research. Key relationships include: activates, implicated in. Associated with Als, Ms. Connected to 14 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolHRH3
Full NameHistamine Receptor H3
Chromosome20q13.33
FunctionHRH3 encodes the H3 histamine receptor.
Primary Expressionthe brain and play roles in cognitive function, attention, and motor control
PathwaysDna Methylation, Epigenetic
UniProt ID[Q9Y5N1](https://www.uniprot.org/uniprotkb/Q9Y5N1/entry)
NCBI Gene ID11255
Ensembl IDENSG00000101180
OMIM607340
GeneCardsHRH3
Human Protein AtlasHRH3
Associated DiseasesNarcolepsy, cognition, addiction
InteractionsHCRTR2, ADRA1B, DRD1, GRIA1, ADRA1A, HRH1
KG Connections13 knowledge graph edges
DatabasesGeneCardsHPASTRING

Wiki Pages (12)

Knowledge base pages for this entity

Canonical Page

HRH3 Gene

gene · 500 words

Histamine

entity · 4009 words

GRIN1 — NMDA Receptor Subunit 1

gene · 2946 words

histamine-h3-heteroreceptor-neurons

cell_type · 1962 words

Tuberomammillary Nucleus Histaminergic Neurons

cell · 1254 words

Tuberomammillary Nucleus Neurons

cell · 1029 words

Pathway Diagram

graph TD
    HRH3["<b>HRH3</b>"]
    Ms{"Ms"}
    HRH3 -->|"activates"| Ms
    Als{"Als"}
    HRH3 -->|"activates"| Als
    HCRTR2["HCRTR2"]
    HRH3 -->|"activates"| HCRTR2
    ADRA1B["ADRA1B"]
    HRH3 -->|"activates"| ADRA1B
    DRD1["DRD1"]
    HRH3 -->|"activates"| DRD1
    GRIA1["GRIA1"]
    HRH3 -->|"activates"| GRIA1
    ADRA1A["ADRA1A"]
    HRH3 -->|"activates"| ADRA1A
    HRH1["HRH1"]
    HRH3 -->|"activates"| HRH1
    GRIN1["GRIN1"]
    HRH3 -->|"activates"| GRIN1
    HCRTR1["HCRTR1"]
    HRH3 -->|"activates"| HCRTR1
    Epigenetic(["Epigenetic"])
    HRH3 -->|"activates"| Epigenetic
    Dna_Methylation(["Dna Methylation"])
    HRH3 -->|"activates"| Dna_Methylation
    DRD2["DRD2"]
    DRD2 -->|"activates"| HRH3
    style HRH3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (12)

TargetRelationTypeStr
Msactivatesdisease0.65
Alsactivatesdisease0.65
HCRTR2activatesgene0.60
ADRA1Bactivatesgene0.60
DRD1activatesgene0.60

Incoming (1)

SourceRelationTypeStr
DRD2activatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found