Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about IMMUNE SYSTEM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | IMMUNE SYSTEM |
Knowledge base pages for this entity
graph TD
IMMUNE_SYSTEM["IMMUNE SYSTEM"]
IMMUNE_SYSTEM -->|"interacts"| Nervous_System["Nervous System"]
IMMUNE_SYSTEM -->|"involved_in"| Neuropathic_Pain["Neuropathic Pain"]
IMMUNE_SYSTEM -->|"contributes to"| Biological_Aging["Biological Aging"]
IMMUNE_SYSTEM -->|"involved_in"| Pathogen_Elimination["Pathogen Elimination"]
IMMUNE_SYSTEM -->|"contributes to"| Autoimmune_Diseases["Autoimmune Diseases"]
IMMUNE_SYSTEM -->|"mediates"| Microbiota_Gut_Brain_Axis["Microbiota-Gut-Brain Axis"]
IMMUNE_SYSTEM -.protects against.-> Infectious_Diseases["Infectious Diseases"]
IMMUNE_SYSTEM -->|"regulates"| mood_regulation["mood regulation"]
Microbiota["Microbiota"] -->|"interacts"| IMMUNE_SYSTEM
Gut_Microbiota["Gut Microbiota"] -->|"modulates"| IMMUNE_SYSTEM
Tumor_Cells["Tumor Cells"] -->|"interacts"| IMMUNE_SYSTEM
Extracellular_Vesicles["Extracellular Vesicles"] -->|"participates in"| IMMUNE_SYSTEM
IFN_gamma["IFN-gamma"] -->|"regulates"| IMMUNE_SYSTEM
Testosterone["Testosterone"] -->|"regulates"| IMMUNE_SYSTEM| Target | Relation | Type | Str |
|---|---|---|---|
| Nervous System | interacts_with | process | 0.95 |
| Neuropathic Pain | involved_in | disease | 0.95 |
| Biological Aging | contributes_to | process | 0.95 |
| Pathogen Elimination | involved_in | process | 0.95 |
| Autoimmune Diseases | contributes_to | disease | 0.95 |
| Tissue Homeostasis | associated_with | process | 0.95 |
| Microbiota-Gut-Brain Axis | mediates | pathway | 0.90 |
| Infectious Diseases | protects_against | disease | 0.90 |
| Biological Aging | associated_with | process | 0.90 |
| mood regulation | regulates | process | 0.88 |
| Neuronal Compartment | interacts_with | cell_type | 0.85 |
| Gut-Brain Axis | component_of | pathway | 0.85 |
| Infectious Diseases | associated_with | disease | 0.85 |
| Glioblastoma | involved_in | disease | 0.85 |
| Brain Tumor | modulates | disease | 0.80 |
| neurodegeneration | contributes_to | disease | 0.80 |
| Alzheimer's Disease | associated_with | disease | 0.80 |
| Parkinson'S Disease | involved_in | disease | 0.80 |
| Glioblastoma Progression | modulates | phenotype | 0.75 |
| Autoimmune Disease | associated_with | disease | 0.75 |
| Cancer | associated_with | disease | 0.75 |
| neuroinflammation | regulates | process | 0.70 |
| Major depressive disorder | associated_with | disease | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| APOE | involved_in | gene | 0.92 |
| Glycosylation Changes | associated_with | process | 0.90 |
| Epithelium | interacts_with | cell_type | 0.90 |
| Microbiota | interacts_with | process | 0.90 |
| Gut Microbiota | modulates | process | 0.88 |
| Allostatic Load | associated_with | phenotype | 0.85 |
| Tumor Cells | interacts_with | cell_type | 0.85 |
| Targeted Treatments | targets | drug | 0.85 |
| NAD+ metabolism | regulates | pathway | 0.85 |
| Cellular Senescence | involved_in | process | 0.85 |
| Extracellular Vesicles | participates_in | biological_process | 0.80 |
| IFN-gamma | regulates | protein | 0.80 |
| Testosterone | regulates | entity | 0.80 |
| ANXA1 | involved_in | protein | 0.80 |
| APOE | associated_with | gene | 0.80 |
| Gut Microbiota | interacts_with | process | 0.80 |
| Glioblastoma | associated_with | disease | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||